Journal
ACTA PHYSIOLOGICA
Volume 204, Issue 1, Pages 128-136Publisher
WILEY
DOI: 10.1111/j.1748-1716.2011.02295.x
Keywords
Agrin; neuromuscular junction; post-synaptic; synapse; Wnts
Categories
Funding
- BBSRC
- MRC
- Wellcome Trust
- Fondecyt [1100326]
Ask authors/readers for more resources
Wnt proteins play prominent roles in different aspects of neuronal development culminating with the formation of complex neuronal circuits. Here, we discuss new studies addressing the function of Wnt signalling at the peripheral neuromuscular junction (NMJ). In both, invertebrate and vertebrate organisms, Wnt signalling promotes and also inhibits the assembly of the neuromuscular synapse. Here, we focus our attention on recent studies at the vertebrate NMJ that demonstrate that some Wnt proteins collaborate with the Agrin-MuSK signalling to induce post-synaptic differentiation. In contrast, Wnts that activate the Wnt/beta-catenin signalling inhibit post-synaptic differentiation. The dual function of different Wnts might finely modulate the proper apposition of the pre- and post-synaptic terminals during NMJ formation and growth.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available