Journal
ACTA PHYSIOLOGICA
Volume 202, Issue 3, Pages 465-485Publisher
WILEY
DOI: 10.1111/j.1748-1716.2010.02190.x
Keywords
NHE1; NKCC1; osmotic stress; regulatory volume decrease; regulatory volume increase; VRAC
Categories
Funding
- Danish Research Council
- Danish Council for independent research: Natural Sciences
- Lundbeck foundation
- Danish Cancer Society
- Danish Council for independent research: Medical Sciences
- Novo Nordisk Foundation
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Cell volume homeostasis and its fine-tuning to the specific physiological context at any given moment are processes fundamental to normal cell function. The understanding of cell volume regulation owes much to August Krogh, yet has advanced greatly over the last decades. In this review, we outline the historical context of studies of cell volume regulation, focusing on the lineage started by Krogh, Bodil Schmidt-Nielsen, Hans-Henrik Ussing, and their students. The early work was focused on understanding the functional behaviour, kinetics and thermodynamics of the volume-regulatory ion transport mechanisms. Later work addressed the mechanisms through which cellular signalling pathways regulate the volume regulatory effectors or flux pathways. These studies were facilitated by the molecular identification of most of the relevant channels and transporters, and more recently also by the increased understanding of their structures. Finally, much current research in the field focuses on the most up-and downstream components of these paths: how cells sense changes in cell volume, and how cell volume changes in turn regulate cell function under physiological and pathophysiological conditions.
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