Article
Biochemistry & Molecular Biology
Cecilia Leijding, Ida Viken, Joseph D. D. Bruton, Daniel C. C. Andersson, Arthur J. J. Cheng, Hakan Westerblad
Summary: During the initial phase of fatigue, tetanic force decreases despite increasing tetanic cytosolic calcium concentration. However, the increase in calcium concentration has positive effects on force in early fatigue.
Article
Engineering, Biomedical
Mark Gotthelf, DeWayne Townsend, William Durfee
Summary: The newly developed upper-limb assessment tool is simple and engaging for measuring muscle strength and fatigue in children, including those with muscular dystrophy. It motivates children through a game-based interface to complete grip tests. The tool showed good usability and applicability in the tested population.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Chemistry, Physical
Han Li, Zhi Xu, Ming Ma
Summary: This study provides experimental evidence for the temperature dependence of boundary slip at the liquid-solid interface. The results show that the slip length is negatively correlated with temperature for water and 0.1 M NaCl solution, but positively correlated with temperature for 1 M NaCl solution.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Michael Penth, Kordula Schellnhuber, Roland Bennewitz, Johanna Blass
Summary: DNA has become a powerful platform for designing functional nanodevices with significant differences from native DNA. Through Flow Force Microscopy, high flexibility was observed in DNA origami constructs, contributing to understanding DNA nanomechanics and improving DNA nanodevice design.
Review
Biology
E. Mendoza, D. S. Moen, N. C. Holt
Summary: In this article, the authors review the research conducted in the field of experimental biology over the past 100 years, examining how it has both supported and challenged the classic theories regarding muscle activation and force generation. They explore the variation in contraction rates and force-length and force-velocity relationships predicted by these theories across different muscles, and discuss the inclusion of muscle contraction features not explained by the classic theories in routine muscle characterization. They also propose the use of phylogenetic comparative methods to study the effects of factors such as evolutionary history, ecology, behavior, and size on muscle physiology and mechanics.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biology
Letizia Zullo, Alessio Di Clemente, Federica Maiole
Summary: Octopus arms exhibit different roles in arm movements, with longitudinal muscles being used for precise actions and transverse muscles for intense and sustained actions. The structure and morphology of the arm muscles also contribute to their functional specialization. The octopus arm can be seen as a reservoir of possibilities for different types of motion.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biology
Patrick Bakenecker, Tobias Weingarten, Daniel Hahn, Brent Raiteri
Summary: This study investigated the effect of muscle length on residual force enhancement (rFE) during submaximal voluntary contractions of the human quadriceps. The results showed that rFE increased significantly at long and very long muscle lengths, but not at short muscle lengths. Additionally, there were significant relationships between muscle fascicle length and rFE, but not between fascicle stretch amplitude and rFE.
Article
Mechanics
Hanbin Yin, Yinji Ma, Xue Feng
Summary: This paper investigates the peeling behavior of a viscoelastic film bonded to a rigid substrate and establishes a theoretical peeling model. The study reveals three typical relationships between the peeling force and peeling velocity, which depend on the viscous dissipation within the film and the rate-dependent adhesion at the interface. Additionally, factors such as film thickness, interfacial toughness, and interfacial strength are identified as influencing the steady-state peeling force.
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2024)
Article
Biology
Debao Guan, Hao Gao, Li Cai, Xiaoyu Luo
Summary: This study develops a new hybrid active contraction model for myocardial dynamics that combines the active-stress based Hill model and the active strain approach. The model demonstrates a high descriptive capability and accurately simulates cardiac dynamics. It incorporates both passive and active branches, with the active stress formulated using the active strain approach and considering length-dependence and force-velocity relationships. The study also highlights the tight interaction between length-dependence and force-velocity relationships and the potential of the hybrid model in personalized cardiac modeling and understanding multi-scale coupling in active contraction based on the sliding filament theory.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biology
Cameron Hill, Elisabetta Brunello, Luca Fusi, Jesus G. Ovejero, Malcolm Irving
Summary: The study revealed a sequence of structural changes during muscle activation, including thin filament activation, disruption of the helical array of myosin motors, release of myosin motor domains from the folded conformation, and actin attachment. Physiological force generation in skeletal muscle twitch response is limited by incomplete activation of the thick filament and rapid inactivation of both filaments.
Article
Chemistry, Physical
Salvatore Assenza, Ruben Perez
Summary: MADna is a coarse-grained model of double-stranded DNA (dsDNA) that accurately captures the sequence-dependent conformational and elastic features. It has a precision comparable to atomistic simulations and shows good agreement with experimental results, making it a reliable tool for understanding single-molecule experiments and cellular processes involving dsDNA.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2022)
Article
Multidisciplinary Sciences
Yuji Takahashi, Toshiyuki Takahashi, Kazutaka Mukai, Yusaku Ebisuda, Hajime Ohmura
Summary: This study aims to investigate the effects of speed and lead-side on surface electromyography (sEMG) during a canter. The sEMG data were recorded from seven Thoroughbreds and the results showed that muscle activity varied with different speeds regardless of the lead side. Therefore, both the lead side and running speed should be considered during training and/or rehabilitation.
Article
Physiology
Jiayu Shi, Daiki Watanabe, Masanobu Wada
Summary: This study demonstrates that acute vigorous isometric contractions decrease titin-based passive force, possibly due to reduced phosphorylation by protein kinase C alpha, and this decreased titin stiffness may contribute, at least in part, to muscle fatigue.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Genetics & Heredity
T. Kruse, S. Shamai, D. Leflerova, B. Wirth, R. Heller, N. Schloss, H. C. Lehmann, S. Brakemeier, T. Hagenacker, B. Braumann, G. Wunderlich
Summary: This study systematically evaluated the measurement of maximum bite force and endurance, maximum tongue pressure and endurance, as well as maximum mouth opening in adult individuals with SMA types 2 and 3. The results showed that these oral function tests were able to discriminate between individuals with different SMA types, numbers of SMN2 copies, and walking abilities. Maximum tongue pressure and maximum mouth opening are particularly promising as clinical and sensitive outcome measures for clinical trials.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Multidisciplinary Sciences
Martin Groeber, Savvas Stafilidis, Arnold Baca
Summary: Stretch-induced residual force enhancement (rFE) is associated with increased performance in a stretch-shortening cycle (SSC), particularly important for movements at greater muscle-tendon unit lengths.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.