Abscisic acid perception and signaling: structural mechanisms and applications

The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling

(2013) Yang Zhao et al.   CELL RESEARCH

Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13

(2013) Wenqi Li et al.   CELL RESEARCH

An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants

(2013) Minjie Cao et al.   CELL RESEARCH

The PYL4 A194T Mutant Uncovers a Key Role of PYR1-LIKE4/PROTEIN PHOSPHATASE 2CA Interaction for Abscisic Acid Signaling and Plant Drought Resistance

(2013) G. A. Pizzio et al.   PLANT PHYSIOLOGY

Vacuolar Transport of Abscisic Acid Glucosyl Ester Is Mediated by ATP-Binding Cassette and Proton-Antiport Mechanisms in Arabidopsis

(2013) B. Burla et al.   PLANT PHYSIOLOGY

Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR

(2013) Xingliang Zhang et al.   PLoS One

Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance

(2013) M. Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABA transport and transporters

(2013) Yann Boursiac et al.   TRENDS IN PLANT SCIENCE

Crystal structures of the Arabidopsis thaliana abscisic acid receptor PYL10 and its complex with abscisic acid

(2012) Demeng Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ArabidopsisPYR/PYL/RCAR Receptors Play a Major Role in Quantitative Regulation of Stomatal Aperture and Transcriptional Response to Abscisic Acid

(2012) Miguel Gonzalez-Guzman et al.   PLANT CELL

A Vacuolar  -Glucosidase Homolog That Possesses Glucose-Conjugated Abscisic Acid Hydrolyzing Activity Plays an Important Role in Osmotic Stress Responses in Arabidopsis

(2012) Z.-Y. Xu et al.   PLANT CELL

PYRABACTIN RESISTANCE1-LIKE8 Plays an Important Role for the Regulation of Abscisic Acid Signaling in Root

(2012) R. Antoni et al.   PLANT PHYSIOLOGY

Identification of an abscisic acid transporter by functional screening using the receptor complex as a sensor

(2012) Y. Kanno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism

(2012) Xingliang Zhang et al.   STRUCTURE

A thermodynamic switch modulates abscisic acid receptor sensitivity

(2011) Florine Dupeux et al.   EMBO JOURNAL

Molecular Mechanism for Inhibition of a Critical Component in theArabidopsis thalianaAbscisic Acid Signal Transduction Pathways, SnRK2.6, by Protein Phosphatase ABI1

(2011) Tian Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Arabidopsis thaliana OST1 Provides Insights into the Kinase Regulation Mechanism in Response to Osmotic Stress

(2011) Cristina Yunta et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins

(2011) Qi Hao et al.   MOLECULAR CELL

Arabidopsis decuple mutant reveals the importance of SnRK2 kinases in osmotic stress responses in vivo

(2011) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent and selective activation of abscisic acid receptors in vivo by mutational stabilization of their agonist-bound conformation

(2011) A. Mosquna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases

(2011) L.-M. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

(2011) F.-F. Soon et al.   SCIENCE

Guard Cell Signal Transduction Network: Advances in Understanding Abscisic Acid, CO2, and Ca2+Signaling

(2010) Tae-Houn Kim et al.   Annual Review of Plant Biology

Abscisic Acid: Emergence of a Core Signaling Network

(2010) Sean R. Cutler et al.   Annual Review of Plant Biology

Structural and functional insights into core ABA signaling

(2010) Joshua J Weiner et al.   CURRENT OPINION IN PLANT BIOLOGY

Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases

(2010) A. Marx et al.   FASEB JOURNAL

Functional Mechanism of the Abscisic Acid Agonist Pyrabactin

(2010) Qi Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Amino Acid Alteration between Valine and Isoleucine Determines the Distinct Pyrabactin Selectivity by PYL1 and PYL2

(2010) Xiaoqiu Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sucrose non-fermenting-1-related (SnRK) family of protein kinases: potential for manipulation to improve stress tolerance and increase yield

(2010) P. Coello et al.   JOURNAL OF EXPERIMENTAL BOTANY

Structural basis for selective activation of ABA receptors

(2010) Francis C Peterson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification and mechanism of ABA receptor antagonism

(2010) Karsten Melcher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Basis of the Core Regulatory Network in ABA Responses: Sensing, Signaling and Transport

(2010) T. Umezawa et al.   PLANT AND CELL PHYSIOLOGY

Phospho-site mapping, genetic and in planta activation studies reveal key aspects of the different phosphorylation mechanisms involved in activation of SnRK2s

(2010) Florina Vlad et al.   PLANT JOURNAL

ABC transporter AtABCG25 is involved in abscisic acid transport and responses

(2010) T. Kuromori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid

(2010) J. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase

(2009) Aiko Sato et al.   BIOCHEMICAL JOURNAL

Two Novel GPCR-Type G Proteins Are Abscisic Acid Receptors in Arabidopsis

(2009) Sona Pandey et al.   CELL

In vitro reconstitution of an abscisic acid signalling pathway

(2009) Hiroaki Fujii et al.   NATURE

Structural basis of abscisic acid signalling

(2009) Ken-ichi Miyazono et al.   NATURE

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

The abscisic acid receptor PYR1 in complex with abscisic acid

(2009) Julia Santiago et al.   NATURE

A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors

(2009) Karsten Melcher et al.   NATURE

Structural insights into the mechanism of abscisic acid signaling by PYL proteins

(2009) Ping Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Three SnRK2 Protein Kinases are the Main Positive Regulators of Abscisic Acid Signaling in Response to Water Stress in Arabidopsis

(2009) Yasunari Fujita et al.   PLANT AND CELL PHYSIOLOGY

Three Arabidopsis SnRK2 Protein Kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, Involved in ABA Signaling are Essential for the Control of Seed Development and Dormancy

(2009) Kazuo Nakashima et al.   PLANT AND CELL PHYSIOLOGY

Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs

(2009) Julia Santiago et al.   PLANT JOURNAL

PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis

(2009) Noriyuki Nishimura et al.   PLANT JOURNAL

AREB1, AREB2, and ABF3 are master transcription factors that cooperatively regulate ABRE-dependent ABA signaling involved in drought stress tolerance and require ABA for full activation

(2009) Takuya Yoshida et al.   PLANT JOURNAL

Transcriptional Regulatory Networks in Response to Abiotic Stresses in Arabidopsis and Grasses

(2009) K. Nakashima et al.   PLANT PHYSIOLOGY

Triple Loss of Function of Protein Phosphatases Type 2C Leads to Partial Constitutive Response to Endogenous Abscisic Acid

(2009) S. Rubio et al.   PLANT PHYSIOLOGY

Arabidopsis mutant deficient in 3 abscisic acid-activated protein kinases reveals critical roles in growth, reproduction, and stress

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis

(2009) T. Umezawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair

(2009) Dietmar Geiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells

(2009) Sung Chul Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Runners-Up

(2009)   SCIENCE

Structural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1

(2009) N. Nishimura et al.   SCIENCE

The ABA receptors – we report you decide

(2008) Peter McCourt et al.   CURRENT OPINION IN PLANT BIOLOGY

CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells

(2008) Juntaro Negi et al.   NATURE

SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling

(2008) Triin Vahisalu et al.   NATURE

Nuclear localization of the mutant protein phosphatase abi1 is required for insensitivity towards ABA responses in Arabidopsis

(2008) Danièle Moes et al.   PLANT JOURNAL

High Humidity Induces Abscisic Acid 8'-Hydroxylase in Stomata and Vasculature to Regulate Local and Systemic Abscisic Acid Responses in Arabidopsis

(2008) M. Okamoto et al.   PLANT PHYSIOLOGY