Journal
ACTA PHARMACOLOGICA SINICA
Volume 35, Issue 9, Pages 1103-1110Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2014.73
Keywords
microparticle; blood cell; endothelial cell; venous thromboembolism; intercellular communication; inflammation; cancer
Funding
- Shanghai Municipal Bureau of Health Youth Scientific Research Projects [2009Y071]
- Shanghai Committee of Science and Technology Research Projects [11411951400]
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Microparticles are small membrane fragments shed primarily from blood and endothelial cells during either activation or apoptosis. There is mounting evidence suggesting that microparticles perform a large array of biological functions and contribute to various diseases. Of these disease processes, a significant link has been established between microparticles and venous thromboembolism. Advances in research on the role of microparticles in thrombosis have yielded crucial insights into possible mechanisms, diagnoses and therapeutic targets of venous thromboembolism. In this review, we discuss the definition and properties of microparticles and venous thromboembolism, provide a synopsis of the evidence detailing the contributions of microparticles to venous thromboembolism, and propose potential mechanisms, by which venous thromboembolism occurs. Moreover, we illustrate a possible role of microparticles in cancer-related venous thromboembolism.
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