Journal
ACTA PHARMACOLOGICA SINICA
Volume 34, Issue 2, Pages 199-204Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2012.202
Keywords
ion channel; antibody; autoimmune neurological disorder; channelopathy; protein-based therapeutics
Funding
- National Institutes of Health [GM078579, MH084691]
- Maryland Stem Cell Research Foundation [2010-MSCRFE-0164-00]
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The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases.
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