Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway
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Title
Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway
Authors
Keywords
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Journal
ACTA PHARMACOLOGICA SINICA
Volume 33, Issue 4, Pages 551-557
Publisher
Springer Nature
Online
2012-03-05
DOI
10.1038/aps.2012.9
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Note: Only part of the references are listed.- Phosphorylation of H2AX at Ser139 and a New Phosphorylation Site Ser16 by RSK2 Decreases H2AX Ubiquitination and Inhibits Cell Transformation
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- Wip1 Directly Dephosphorylates -H2AX and Attenuates the DNA Damage Response
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- MST1 Promotes Apoptosis through Phosphorylation of Histone H2AX
- (2010) Weihong Wen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair
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- Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl
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- Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition
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- Imatinib Resistance and Progression of CML to Blast Crisis: Somatic Hypermutation AIDing the Way
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- Haploinsufficiency and acquired loss ofBcl11bandH2AXinduces blast crisis of chronic myelogenous leukemia in a transgenic mouse model
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- Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
- (2009) Peter J. Cook et al. NATURE
- Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway
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- Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines
- (2008) Yasuyuki Deguchi et al. LEUKEMIA RESEARCH
- Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis
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- WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
- (2008) Andrew Xiao et al. NATURE
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