Simultaneous TLR2 inhibition and TLR9 activation synergistically suppress tumor metastasis in mice

TLR2-Dependent Induction of IL-10 and Foxp3+CD25+CD4+ Regulatory T Cells Prevents Effective Anti-Tumor Immunity Induced by Pam2 Lipopeptides In Vivo

(2011) Sayuri Yamazaki et al.   PLoS One

Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy

(2011) Jun Yan et al.   PLoS One

TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

(2010) Chao Wang et al.   BMC CANCER

Polysaccharide Krestin Is a Novel TLR2 Agonist that Mediates Inhibition of Tumor Growth via Stimulation of CD8 T Cells and NK Cells

(2010) H. Lu et al.   CLINICAL CANCER RESEARCH

Targeting inhibitory pathways in cancer immunotherapy

(2010) Marcio O Lasaro et al.   CURRENT OPINION IN IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Immunotherapy of Cancer: Key Findings and Commentary on the Third Tegernsee Conference

(2010) D. Ruttinger et al.   ONCOLOGIST

Toll-Like Receptor 2 Signaling Protects Mice from Tumor Development in a Mouse Model of Colitis-Induced Cancer

(2010) Emily L. Lowe et al.   PLoS One

IFN-γ-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer

(2010) Matteo Martini et al.   VACCINE

Toll-like receptor 2 mediates invasion via activating NF-κB in MDA-MB-231 breast cancer cells

(2009) Wenjie Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes

(2009) F. Fallarino et al.   JOURNAL OF IMMUNOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor

(2009) Hong-Zhen Yang et al.   PLoS One

Route of Administration of the TLR9 Agonist CpG Critically Determines the Efficacy of Cancer Immunotherapy in Mice

(2009) Stefan Nierkens et al.   PLoS One

Effective CpG Immunotherapy of Breast Carcinoma Prevents but Fails to Eradicate Established Brain Metastasis

(2008) Z. Xiong et al.   CLINICAL CANCER RESEARCH

Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model

(2008) Ommoleila Molavi et al.   IMMUNOLOGY AND CELL BIOLOGY

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE

Advances in tumour immunotherapy

(2008) J. King et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE