Current understanding of TRPM7 pharmacology and drug development for stroke

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Blockade of TRPM7 Channel Activity and Cell Death by Inhibitors of 5-Lipoxygenase

(2010) Hsiang-Chin Chen et al.   PLoS One

Guidelines for the Primary Prevention of Stroke

(2010) Larry B. Goldstein et al.   STROKE

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels

(2009) Moshe Parnas et al.   CELL CALCIUM

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

(2009) Hong-Shuo Sun et al.   NATURE NEUROSCIENCE

Hemorrhagic and Ischemic Strokes Compared

(2009) Klaus Kaae Andersen et al.   STROKE

Efficacy and Safety of Tissue Plasminogen Activator 3 to 4.5 Hours After Acute Ischemic Stroke

(2009) Maarten G. Lansberg et al.   STROKE

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

The α-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC

(2008) Kristopher Clark et al.   FEBS LETTERS

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

(2008) Manuel Yepes et al.   TRENDS IN NEUROSCIENCES

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

(2008) Elaine Besancon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES