Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Daniel Richter, Jeyanthan Charles James, Andreas Ebert, Aristeidis H. Katsanos, Lisa Mazul-Wach, Quirin Ruland, Ralf Gold, Georg Juckel, Christos Krogias
Summary: Early SSRI therapy is associated with a reduced risk of post-stroke depression, but increases the risk of bone fracture and nausea. Future research should focus on identifying high-risk individuals to improve the risk-benefit assessment of this therapy in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Shao-Fei Liu, Netra Nambiar Veetil, Qiuhua Li, Mariya M. M. Kucherenko, Christoph Knosalla, Wolfgang M. M. Kuebler
Summary: Pulmonary hypertension is a progressive disease caused by inflammation, which leads to pulmonary arterial stiffness and vascular remodeling, driving the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lei Chen, Ying-Jian Gu, Ming-Yuan Zhou, Lin Cheng, Yun Wang
Summary: Microvesicles play an important role in the pathogenesis of pulmonary arterial hypertension by transferring inflammatory factors and may become a potential therapeutic target for the disease.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: The exposure to antidepressants during pregnancy, especially SSRIs, is associated with a slightly increased risk of postpartum hemorrhage. However, the findings should be interpreted with caution, and precautionary measures are still recommended.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Respiratory System
Fangwei Li, Dan Wang, Hong Wang, Lijun Chen, Xilu Sun, Yixin Wan
Summary: The study found that up-regulation of HDAC1 is involved in the development of pulmonary arterial hypertension (PAH). Inhibition of HDAC1 suppresses PAH development by restoring miR-34a level in MCT-induced PAH rats, leading to the reduction of MMP-9/TIMP-1 and MMP-2/TIMP-2 ratio which contributes to pulmonary arterial remodeling and PAH progression.
RESPIRATORY RESEARCH
(2021)
Article
Oncology
Min-Jing Lee, Chien-Wei Huang, Yi-Lung Chen, Yao-Hsu Yang, Vincent Chin-Hung Chen
Summary: The study revealed an association between the use of SSRIs and decreased risk of kidney cancer, with citalopram and paroxetine showing protective effects in depressed patients with kidney cancer during a 2-year induction period.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Chemistry, Medicinal
Grazielle Fernandes Silva, Jaqueline Soares da Silva, Allan Kardec Nogueira de Alencar, Marina de Moraes Carvalho da Silva, Tadeu Lima Montagnoli, Bruna de Souza Rocha, Rosana Helena Coimbra Nogueira de Freitas, Roberto Takashi Sudo, Carlos Alberto Manssour Fraga, Gisele Zapata-Sudo
Summary: The effects of a newly designed p38 inhibitor, LASSBio-1824, were investigated in experimentally induced pulmonary hypertension. The study showed that LASSBio-1824 normalized vascular resistance by attenuating vessel muscularization and endothelial dysfunction, improving cardiac function and reducing hypertrophy and collagen content in the heart.
Article
Pharmacology & Pharmacy
Soobeen Hwang, Jong-Hui Kim, Su-Hyun Jo
Summary: Paroxetine can acutely and directly modulate human Kv1.3 channels, inhibiting channel activity by accelerating steady-state inactivation, thus revealing a possible mechanism for acute immunosuppression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Rafael R. Domingues, Hannah P. Fricke, Celeste M. Sheftel, Autumn M. Bell, Luma C. Sartori, Robbie S. J. Manuel, Chandler J. Krajco, Milo C. Wiltbank, Laura L. Hernandez
Summary: The effects of SSRI drugs on pregnancy and neonatal outcomes in mice were investigated. The study found that the high dose of fluoxetine led to a decrease in pregnancy rate and maternal weight gain, while both high and low doses of sertraline led to a decrease in the number of pups born and weaned. The study suggests that the effects of SSRI on neonatal mortality may be mediated by SSRI-induced placental insufficiency.
Review
Genetics & Heredity
Luis Pedro Baptista de Barros Ribeiro Dourado, Mario Santos, Daniel Moreira-Goncalves
Summary: This review analyzes the potential involvement of neutrophil extracellular traps (NETs) in pulmonary arterial hypertension (PAH), highlighting their role in platelet and endothelial cell activation. The formation of NETs may be induced by endothelial signaling and platelet-neutrophil interaction, creating a positive feedback loop. Confirming the role of NETs in PAH could open up new avenues for therapeutic research.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Neurosciences
Robyn P. Thom, Michelle L. Palumbo, Claire Thompson, Christopher J. McDougle, Caitlin T. Ravichandran
Summary: The study found that the majority of adults with Down syndrome responded positively to a 12-week course of SSRI treatment for depression, with some experiencing adverse effects such as daytime sedation and anger. Controlled studies are needed to further evaluate the efficacy, tolerability, and safety of SSRIs in this population.
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Biochemistry & Molecular Biology
Aimilia Eirini Papathanasiou, Fotios Spyropoulos, Zoe Michael, Kyoung E. Joung, Despina D. Briana, Ariadne Malamitsi-Puchner, Christos S. Mantzoros, Helen Christou
Summary: The study found significantly elevated levels of fatty acid binding protein 4, fibroblast growth factor-21, and adiponectin in the circulation of pulmonary hypertension patients, with increased mRNA levels of these metabolic regulators and PPAR γ gene in patient lung tissue. Experimental rodent models of PH and human patients demonstrated increased gene expression related to glucose uptake, glycolysis, tricarboxylic acid cycle, and fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Juhee Lim, Yeojin Bang, Kyeong-Man Kim, Hyun Jin Choi
Summary: This study investigated the effects of differentiation on the serotonergic neuronal phenotype of the mouse hippocampal neuronal cell line HT22. The results showed that differentiation promoted neurite outgrowth and upregulation of N-methyl-D-aspartate receptor and choline acetyltransferase in HT22 cells. Furthermore, proteins required for serotonergic neurotransmission were significantly upregulated in differentiated HT22 cells. These findings suggest that differentiated HT22 cells have enhanced functional serotonergic properties and could be used for assessing the efficacy of antidepressant 5-HT reuptake inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Yan Deng, Zhu Chen, Hui Chen, Song Li, Franklin Wang-Ngan Chow, Polly H. M. Leung, Hanming Wang, Lei Cai, Nongyue He
Summary: Since the concept of aptamer emerged, extensive research has been conducted, but there is a lack of practical applications for nucleic acids aptamer targeting cells. The complexity and irreproducibility of aptamer screening experiments are major obstacles. In response to this, the research group has developed an automated screening instrument for tumor cell nucleic acid aptamers and comprehensively characterized their properties.
CHINESE CHEMICAL LETTERS
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Xiaolan Gao, Yiwen Deng, Hanming Wang, Wei Liu
Article
Engineering, Electrical & Electronic
Hanming Wang, Jinghong Zhao, Guoqiang Guo, Hansi Chen, Yiyong Xiong, Sinian Yan
Summary: This paper investigates the optimization design issues of linear induction motors and proposes an analytical model, an iterative design method, and a multi-objective optimal design method. The results indicate that the proposed methods have competitive performance.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Guohua Zhou, Yufen Wang, Kena Wu, Hanming Wang
Summary: This paper proposes a localization method for underwater sensors based on the optimization of magnetic field gradients. By optimizing the positions of the magnetic source and the sensors, accurate localization can be achieved.
Article
Engineering, Chemical
Jie Xue, Jinghong Zhao, Sinian Yan, Hanming Wang, Changduo Zhou, Dongao Yan, Hansi Chen
Summary: In this study, an analytical model of an unequal-pitch linear phase-shifting transformer was established using the distributed magnetic circuit method and Schwartz-Christopher transformation. By considering variables such as magnetic field strength, an accurate magnetic field analysis model was developed, taking into account saturation, cogging, and edge effects. The model's accuracy and feasibility were verified through finite element method simulations and experiments. This research method can also be applied to establish magnetic field models for other similar structures in new energy power systems, particularly those with cogging structures.
Article
Biotechnology & Applied Microbiology
Zhu Chen, Kaixuan Zhao, Boyu Tan, Zengrui Tong, Ziyu He, Xiaofang Luo, Lei Cai, Hanming Wang, Polly H. M. Leung, Franklin Wang-Ngai Chow, Hui Chen, Yan Deng
Summary: This paper reports a method for HSV type testing, which includes selection, design, and synthesis of specific primers, validation of amplification products by sequencing and analysis, and optimization of reaction system and PCR reaction program by orthogonal design and sensitivity testing. Results showed that this method has great potentials for HSV type testing, with a lowest detection limit of approximately 6.67 x 10(6) copies/ml, and high specificity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Energy & Fuels
Hansi Chen, Jinghong Zhao, Hanming Wang, Qingfei Zhang, Xiangyu Luo, Hao Xu, Yiyong Xiong
Summary: This paper presents an analytical design optimization method for the five-phase squirrel cage induction motor (FSCIM) based on the coupling of electromagnetic equivalent circuit (EEC) and differential evolution algorithm (DEA). The effects of design parameters on motor performance are evaluated using an analytical model, and various factors are considered in the comprehensive objective function calculation. Transient finite element analysis and experimental testing confirm the accuracy of the proposed model.
Article
Computer Science, Artificial Intelligence
Hanming Wang, Jinghong Zhao
Summary: The high-level target navigation Pigeon-inspired optimization (HTNPIO) is an improvement over the canonical Pigeon-inspired optimization (PIO). It enhances the global exploration capability by introducing selective mutation strategy, levy-based map-compass strategy, and enhanced landmark strategy to balance exploration and exploitation. Experimental results demonstrate that HTNPIO performs well on benchmark problems and real-world problems, providing promising solutions.
APPLIED INTELLIGENCE
(2023)
Article
Engineering, Mechanical
Xuhui Pei, Yin Du, Hanming Wang, Mingchuan Hu, Haifeng Wang, Weimin Liu
Summary: The effect of Si addition on the high temperature tribological properties of TiZrV0.5Nb0.5 refractory high entropy alloy was systematically studied. The results show that Si-microalloying can modulate the evolution of tribo-layer, thus affecting the tribological properties. Si-microalloying increases the sintering rate of wear debris at low temperatures, resulting in a local tribo-layer with strong wear resistance. However, at high temperatures, Si-microalloying leads to stress concentration and accelerated fracture of the tribo-layer, reducing the wear resistance.
TRIBOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Liqing Chi, Lin Huan, Chunyan Zhang, Hanming Wang, Jian Lu
Summary: Ovarian cancer is highly lethal with limited therapeutic options. PARP inhibitor (PARPi) has shown efficacy as a maintenance therapy, but resistance to PARPi is a major challenge. In this study, we identified increased expression of adenosine receptor A2b (Adora2b/A(2B)) and activation of the inflammatory pathway in Olaparib-resistant ovarian cancer cells. A(2B) was also highly expressed in recurrent ovarian tumors and associated with poor clinical outcomes. Blocking the A(2B)-IL-6-STAT3 axis overcame Olaparib resistance and inhibited tumor cell growth. These findings highlight the critical role of A(2B) signaling in PARPi resistance and provide potential targets for novel therapies in ovarian cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Engineering, Mechanical
Wenting Ye, Mingda Xie, Zhuobin Huang, Hanming Wang, Qing Zhou, Long Wang, Biao Chen, Haifeng Wang, Weimin Liu
Summary: In-situ carbide/CoCrFeNiMn composites were fabricated with graphene oxide, leading to improved wear resistance due to the formation of hard carbide phase and strong interfacial bonding.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Engineering, Electrical & Electronic
Changduo Zhou, Jinghong Zhao, Hanming Wang, Sinian Yan, Dongao Yan
Summary: This paper proposes an inverter system based on a linear phase-shifting transformer to improve its electrical performance and make the output waveform close to a sinusoidal waveform by eliminating low harmonics with opposite phase through phase shift and superposition effect. The components and working process of the multiple superposition inverter system are introduced, and the working principle and winding structure of the linear phase-shifting transformer are analyzed. Fourier decomposition of the inverter output voltage is conducted to obtain harmonic currents at the same frequency, and it is demonstrated that the inverter can eliminate most of the harmonics below the 23rd order. The effectiveness of the inverter device and winding structure on harmonic suppression is proved through spectral analysis of voltage waveforms with different load types and power factors, and experiments verify the reasonableness and accuracy of the proposed method.
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Xuhui Pei, Yin Du, Tao Li, Hanming Wang, Mingchuan Hu, Haifeng Wang
Summary: TiZrV0.5Nb0.5Six (x = 0.1, 0.2, 0.3) refractory high entropy alloys were used to evaluate the relationship between microstructure, mechanical properties, and elevated temperature service performance. Increasing Si addition resulted in a transition from single-phase BCC to dual-phase BCC and silicide, accompanied by increased micro-hardness/strength and improved wear and oxidation resistance. The formation of a strong silicide phase inhibited oxide layer cracking and volatilization, leading to excellent oxidation resistance. Improved wear resistance was attributed to enhanced micro-hardness and formation of a dense glaze layer at elevated temperatures. These findings provide insights into designing refractory high entropy alloys for harsh environments.
MATERIALS CHARACTERIZATION
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Li Yan, Hanming Wang, Jiefu Chen
Summary: This paper investigates the formation prediction and look-ahead capability of ultra-deep electromagnetic logging tool in low-angle drilling operations. By incorporating a reference model into the cost function, the look-ahead capability can be significantly improved.
2022 PHOTONICS & ELECTROMAGNETICS RESEARCH SYMPOSIUM (PIERS 2022)
(2022)
Article
Engineering, Electrical & Electronic
Hanming Wang, Jinghong Zhao, Yiyong Xiong, Hao Xu, Sinian Yan
Summary: In this paper, a new optimization method is proposed to improve the efficiency and power factor of linear induction motors (LIMs) used in urban rail transit. The method is based on a steady state equivalent circuit model and the differential evolutionary algorithm. The optimized motor design is validated using a 2D transient finite element method.
WORLD ELECTRIC VEHICLE JOURNAL
(2022)