Review
Medicine, Research & Experimental
Ahmed A. Elmarakby, Jennifer C. Sullivan
Summary: Although there have been numerous clinical and experimental studies identifying a sexual dimorphism in blood pressure control, the specific mechanisms underlying these differences remain unclear. Previous research has suggested that differential regulation of adrenergic receptors, the renin-angiotensin system, oxidative stress, nitric oxide bioavailability and immune cells play a role in sex differences in blood pressure control in SHR.
Article
Medicine, General & Internal
Agnieszka Wsol, Agata Gondek, Martyna Podobinska, Marek Chmielewski, Elzbieta Sajdel-Sulkowska, Agnieszka Cudnoch-Jedrzejewska
Summary: This study found that the presence of arterial hypertension is associated with increased activity of the oxytocinergic system in the heart, especially in the area of the left ventricle. These findings support the important role of this system in the maintenance of cardiovascular homeostasis.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Peripheral Vascular Disease
Ibrahim M. Salman
Summary: This study assessed the contribution of left and right aortic baroreceptor afferents to baroreflex modulation in female spontaneously hypertensive rats (SHRs). The results showed that female SHRs, unlike male SHRs, express similar central integration of left versus right aortic baroreceptor afferent input during hypertension. Clinically, unilateral targeting of the left or right aortic baroreceptor afferents may provide adequate reductions in blood pressure in female hypertensive patients.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Ibrahim M. Salman, Omar Z. Ameer, Sheridan McMurray, Sarah F. Hassan, Arun Sridhar, Stephen J. Lewis, Yee-Hsee Hsieh
Summary: This study investigated the impact of signals from left and right aortic baroreceptor on cardiovascular reflex in hypertensive rats. The results showed that under hypertensive conditions, left and bilateral stimulation caused stronger reflex blood pressure reduction and greater bradycardia. These findings indicate that lateralization in aortic baroreceptor signal processing remains evident in hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Koji Kawabeta, Masahiro Yuasa, Michihiro Sugano, Kazunori Koba
Summary: Dietary beta-conglycinin has been shown to lower blood pressure in spontaneously hypertensive rats by increasing plasma adiponectin concentration and possibly regulating the renin-angiotensin system.
Article
Endocrinology & Metabolism
Santiago Ronchetti, Florencia Labombarda, Paulina Roig, Alejandro F. De Nicola, Luciana Pietranera
Summary: The phytoestrogen genistein has neuroprotective effects in hypertensive rats, reversing hippocampal abnormalities, reducing inflammation, and improving memory. This suggests that genistein could be a potential alternative therapy for hypertensive encephalopathy.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Yu, Yan Ma, Xin He, Xiao Na Long, Jun Xu, Lei Wang, Zhi-Peng Feng, Hong-Ying Peng
Summary: The objective of this study was to investigate the effects of irbesartan and amlodipine besylate tablets on the intestinal microflora of rats with hypertensive renal damage. The results showed that irbesartan was better than amlodipine besylate at improving the diversity of the intestinal flora in these rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Emilson Donizete Pereira Jr, Laurival A. De Luca Jr, Jose Vanderlei Menani, Carina Aparecida Fabricio Andrade
Summary: The study found that spontaneously hypertensive rats (SHRs) have enhanced responses to sweet taste and increased aversive responses to bitter taste, which are independent of challenges in bodily fluid balance.
Article
Multidisciplinary Sciences
Camila B. Gardim, Ana Catarine Veiga, Bruno A. Aguilar, Stella V. Philbois, Hugo C. D. Souza
Summary: The combination of pyridostigmine bromide and physical training in spontaneously hypertensive rats (SHRs) resulted in significant hemodynamic changes and increased vagal influence on cardiac autonomic balance.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Philip R. Griffiths, Stephen J. Lolait, Julian F. R. Paton, Anne-Marie O'carroll
Summary: The study found elevated APJ gene expression in the sensory circumventricular organs (CVOs) and greater mean arterial blood pressure (MABP) decrease following microinjection of [Pyr(1)]apelin-13 into the CVOs of spontaneously hypertensive rats (SHRs) compared to normotensive controls. Knockdown of aplnr in the CVOs abolished the MABP responses to [Pyr(1)]apelin-13 injection, suggesting that functional APJ in the CVOs is required for an intact cardiovascular response to peripherally administered apelin in SHRs.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Julia Chu-Ning Hsu, Shinichi Sekizawa, Ryota Tochinai, Masayoshi Kuwahara
Summary: The study suggests that injecting a metabotropic glutamate receptor antagonist into the brainstem can slightly increase systolic blood pressure in young spontaneously hypertensive rats. This effect is associated with an increase in blood catecholamine concentration and can last even after the treatment ends. However, this treatment has little effect on autonomic activity.
Article
Peripheral Vascular Disease
Dapeng Li, Fangyuan Cao, Jie Han, Mengke Wang, Chunhao Lai, Jingjing Zhang, Tianqi Xu, Ayache Bouakaz, Mingxi Wan, Pengyu Ren, Siyuan Zhang
Summary: The objective of this study was to investigate the sustainable antihypertensive effects and protection against target organ damage of low-intensity focused ultrasound (LIFU) stimulation in spontaneously hypertensive rats (SHRs). The results showed that LIFU stimulation can effectively lower blood pressure, improve cardiac and kidney function, and inhibit the renin-angiotensin system activity.
JOURNAL OF HYPERTENSION
(2023)
Article
Medicine, Research & Experimental
Weiquan Zeng, Xiuli Zhang, Yao Lu, Ying Wen, Qiurong Xie, Xuan Yang, Shuyu He, Zhi Guo, Jiapeng Li, Aling Shen, Jun Peng
Summary: This study investigates the effect of neferine on hypertensive vascular remodeling and its underlying mechanisms. The results demonstrate that neferine can effectively reduce blood pressure, pulse wave velocity, and abdominal aortic thickening in hypertensive rats. It also suppresses the abnormal activation of PI3K/AKT and TGF-beta/Smad2/3 signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yuta Okamura, Ryo Niijima, Satoshi Kameshima, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: Hypertension is a major risk factor for cardiovascular diseases, caused by various abnormalities including blood vessel contractibility. This study investigated the effects of human omentin-1 on hypertensive complications in aged SHR. It was found that omentin-1 tended to improve left ventricular and renal failure in SHR, indicating its potential therapeutic role in hypertensive complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Shohei Yamaguchi, Yuzumi Hayasaka, Miho Suzuki, Wenhao Wang, Masahiro Koyama, Yasuko Nagasaka, Kozo Nakamura
Summary: This study demonstrates that low-dose orally administered ACh can lower blood pressure in spontaneously hypertensive rats by acting on gastrointestinal M3 muscarinic ACh receptors to increase afferent vagal nerve activity, resulting in decreased sympathetic nervous activity and noradrenaline release.