Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein

CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity

(2010) Min-you Qi et al.   ACTA PHARMACOLOGICA SINICA

Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia

(2010) Dawei Jiang et al.   Channels

Role of endothelin in the effects of isoprenaline on potassium currents and calsequestrin 2 expression in the heart

(2010) Na Li et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol

(2010) Hong-Jun Peng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ARRHYTHMOGENIC CARDIOMYOPATHY IN A PATIENT WITH NOONAN SYNDROME

(2010) Eugenia Altamirano et al.   Fetal and Pediatric Pathology

A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201

(2009) L. M. Blayney et al.   CARDIOVASCULAR RESEARCH

Stress-induced cardiac insufficiency relating to abnormal leptin and FKBP12.6 is ameliorated by CPU0213, an endothelin receptor antagonist, which is not affected by the CYP3A suppressing effect of erythromycin

(2009) Yu-Si Cheng et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Rhein Improves Renal Lesion and Ameliorates Dyslipidemia in db/db Mice with Diabetic Nephropathy

(2009) Qing Gao et al.   PLANTA MEDICA

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis

(2009) F. Legendre et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway

(2008) J-M Zheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

(2008) H. Tateishi et al.   CARDIOVASCULAR RESEARCH

Absence of Pathognomonic or Inflammatory Patterns in Cardiac Biopsies From Patients With Brugada Syndrome

(2008) Sven Zumhagen et al.   Circulation-Arrhythmia and Electrophysiology

Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: A role of hyperphosphorylation of PKCε

(2008) Na Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice

(2008) Carina Malaguti et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Downregulated FKBP12.6 expression and upregulated endothelin signaling contribute to elevated diastolic calcium and arrhythmogenesis in rat cardiomyopathy produced by l-thyroxin

(2008) Yuan Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent

(2008) Rong-Hui Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Dysregulated sarcoplasmic reticulum calcium release: Potential pharmacological target in cardiac disease

(2008) Sandor Györke et al.   PHARMACOLOGY & THERAPEUTICS

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

(2008) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY