Article
Biochemistry & Molecular Biology
Haiyan Zhou, Tangting Chen, Yongjie Li, Jingcan You, Xin Deng, Ni Chen, Tian Li, Youkun Zheng, Rong Li, Mao Luo, Jianbo Wu, Liqun Wang
Summary: This study found that Tie-2 is modified by AGEs in diabetes, leading to the inhibition of Ang-1 signaling activation and angiogenesis. This finding provides a novel mechanism for Ang-1/Tie-2 signal dysfunction and angiogenesis failure in diabetic ischemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Tangting Chen, Haiyan Zhou, Shuangshuang Yuan, Xin Deng, Yongjie Li, Ni Chen, Jingcan You, Rong Li, Tian Li, Youkun Zheng, Mao Luo, Hongbin Lv, Jianbo Wu, Liqun Wang
Summary: Glycation of fibronectin (FN) can impair the Ang-1/Tie-2 signaling pathway, leading to a dysfunction in angiogenesis and cell survival. This may provide a molecular mechanism for the dysfunction of Ang-1/Tie-2 signaling and angiogenesis failure in diabetic ischemic diseases.
CELLULAR SIGNALLING
(2023)
Review
Pharmacology & Pharmacy
Rui Wang, Moua Yang, Longguang Jiang, Mingdong Huang
Summary: This review focuses on the various functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, atherosclerosis, ocular angiogenesis, tumor angiogenesis, and metastasis. Therapeutic approaches to the Ang-Tie axis are also discussed.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Amelie Marguier, Caroline Laheurte, Benoit Lecoester, Marine Malfroy, Laura Boullerot, Adeline Renaudin, Evan Seffar, Abhishek Kumar, Charlee Nardin, Francois Aubin, Olivier Adotevi
Summary: This study investigates a novel subset of monocytic MDSCs called TIE-2(+) M-MDSCs in melanoma patients. These cells show a highly immunosuppressive phenotype and are associated with the pro-angiogenic factor ANGPT2. The study demonstrates that exposure to ANGPT2 increases the immune suppressive function of TIE-2(+) M-MDSCs and that active TIE-2 signaling is required for optimal suppressive activity. This suggests that the TIE-2(+) M-MDSC/ANGPT2 axis may play a role in immune escape in melanoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Amanda Lima Deluque, Beatriz Magalhaes Oliveira, Claudia Silva Souza, Ana Livia Dias Maciel, Heloisa Della Coletta Francescato, Cleonice Giovanini, Lucas Ferreira de Almeida, Francisco Jose Albuquerque de Paula, Roberto Silva Costa, Jose Antunes-Rodrigues, Terezila Machado Coimbra
Summary: By activating the vitamin D receptor, paricalcitol protects renal endothelial cells from ADR-induced injury, improves the structure and function of glomerulus and tubules, and maintains endothelial cell function and structure through regulating NO production, suppressing fibrotic marker expression, and modulating the angiopoietins and VEGF signaling pathways.
Article
Biochemistry & Molecular Biology
Lihong Lu, Xue Li, Ziwen Zhong, Wenchang Zhou, Di Zhou, Minmin Zhu, Changhong Miao
Summary: The study revealed that KMT5A is involved in hyperglycemia-induced EndMT in diabetic nephropathy by regulating ENO1, suggesting a potential new therapeutic target for this condition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Respiratory System
Lukas Hobohm, Sebastian Kolmel, Caroline Niemann, Philipp Kuempers, Valentin J. Krieg, Magdalena L. Bochenek, Alexander H. Lukasz, Yvonne Reiss, Karl-Heinz Plate, Christoph Liebetrau, Christoph B. Wiedenroth, Stefan Guth, Thomas Muenzel, Gerd Hasenfuss, Philip Wenzel, Eckhard Mayer, Stavros V. Konstantinides, Katrin Schaefer, Mareike Lankeit
Summary: The study found that ANGPT2 can delay venous thrombus resolution, and overexpression of ANGPT2 contributes to thrombus fibrosis, supporting the transition from pulmonary embolism to CTEPH.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Immunology
Cornelia A. M. van de Weg, Mateus Thomazella, Mariana P. Marmorato, Carolina A. Correia, Juliana Z. C. Dias, Alvino Maestri, Luiz G. F. A. B. E. Zanella, Natalia B. Cerqueira, Alvina C. Felix, Carlos H. Moreira, Renata Buccheri, Priscilla R. Costa, Esper G. Kallas
Summary: In a large yellow fever outbreak in Sao Paulo, Brazil in 2018, it was found that angiopoietin 2, a marker related to endothelial damage, is strongly associated with mortality. This suggests that angiopoietin 2 could serve as a predictive marker for fatal outcomes in yellow fever cases.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
F. Fahmideh, N. Marchesi, L. I. M. Campagnoli, L. Landini, C. Caramella, A. Barbieri, S. Govoni, A. Pascale
Summary: Diabetic retinopathy is one of the most common complications of diabetes, and current pharmacological approaches are limited. This study found that a molecular cascade triggered by hyperglycemia can be blocked to prevent the increase of VEGF in the retina, providing a new pharmacological option for preventing the development of diabetic retinopathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Golzar Mobayen, Koval Smith, Kushani Ediriwickrema, Richard D. Starke, Emmanouil Georgios Solomonidis, Michael A. Laffan, Anna M. Randi, Thomas A. J. Mckinnon
Summary: This study demonstrates a direct binding interaction between Angpt-2 and VWF, which persists after secretion. VWF may act to localize Angpt-2, and further research is needed to establish the functional consequences of this interaction.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Tomasz Skowerski, Katarzyna Nabrdalik, Hanna Kwiendacz, Maciej Pajak, Katarzyna Mizia-Stec, Zbigniew Gasior, Janusz Gumprecht
Summary: This study found that serum concentration of Angiopoietin-2 (Ang-2) is elevated in non-ST elevation myocardial infarction (NSTEMI), regardless of the presence of type 2 diabetes mellitus (T2DM). The level of Ang-2 does not correspond with the degree of myocardial injury and hemodynamic status. The elevation of Ang-2 also occurs in T2DM patients without a history of coronary artery disease (CAD).
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Cell Biology
Jianxin Deng, Yunxiu Liao, Jianpin Liu, Wenjuan Liu, Dewen Yan
Summary: Diabetic cardiomyopathy is characterized by diastolic relaxation abnormalities in its early stages and clinical heart failure in its later stages, contributing to high mortality and morbidity rates in diabetic populations. Diabetes is a complex condition influenced by genetic and environmental factors, with recent studies highlighting the role of epigenetics in its pathogenesis. Further research on epigenetic mechanisms could lead to novel therapeutic approaches for diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Peng Zhang, Ji Peng, Yun-Qin Ren, Han Zheng, Hong Yan
Summary: The study demonstrated that dexmedetomidine reduced lung injury and inflammation in a rat sepsis model by decreasing Ang2 levels and increasing VE-cadherin expression. These findings suggest a potential therapeutic application of dexmedetomidine in sepsis treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anna Szymczak, Mariusz Kusztal, Tomasz Golebiowski, Krzysztof Letachowicz, Anna Gozdzik, Katarzyna Koscielska-Kasprzak, Andrzej Tukiendorf, Magdalena Krajewska
Summary: Plasma endothelial and overhydration markers are associated with endothelial activation and can be used to predict the initiation of dialysis in patients with chronic kidney disease. Ang-2 and VCAM-1 showed positive correlations with BTP; multivariate regression analysis showed that VCAM-1 and Ang-2 independently influenced the risk of renal replacement therapy initiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Taylor A. Dodson, Stephan Nieuwoudt, Chase N. Morse, Valinteshley Pierre, Chao Liu, Samuel E. Senyo, Erin G. Prestwich
Summary: We evaluated tRNA modifications in the diabetic heart and found that tRNA modifications play an important role in diabetic etiologies. We quantified tRNA modifications and ribonucleoside levels in healthy and diabetic murine hearts and hyperglycemic cell models. Results showed abnormal ribonucleoside modifications in hyperglycemic models and diabetic tissues. Our findings suggest that tRNA modifications may regulate translation in diabetes.