Article
Medicine, General & Internal
Hsiang-Yu Lin, Ming-Ren Chen, Chung-Lin Lee, Shan-Miao Lin, Chung-Lieh Hung, Dau-Ming Niu, Tung-Ming Chang, Chih-Kuang Chuang, Shuan-Pei Lin
Summary: The study found that aortic root dilatation is common in patients with MPS, with the most severe dilation seen in MPS IV patients. The severity of aortic root dilatation worsens with age. Enzyme replacement therapy appears to stabilize the progression of aortic root dilatation in MPS patients.
Article
Respiratory System
Thomas Gaisl, Protazy Rejmer, Maurice Roeder, Patrick Baumgartner, Noriane A. Sievi, Sandra Siegfried, Simon F. Staempfli, Robert Thurnheer, John R. Stradling, Felix C. Tanner, Malcolm Kohler
Summary: This study found that OSA may be a modest but independent risk factor for faster TAA expansion, potentially contributing to life-threatening complications in aortic disease. There was no association between OSA severity and aortic events in the participants.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Laura Galian-Gay, Antonia Pijuan-Domenech, Javier Cantalapiedra-Romero, Berta Serrano, Maria Goya, Nerea Maiz, Manel Casellas, Susana Manrique, Elena Suarez-Edo, Berta Miranda-Barrio, Blanca Gordon Ramirez, Gisela Teixido-Tura, Laura Gutierrez-Moreno, Victor Gonzalez-Fernandez, Lydia Dux-Santoy, Andrea Guala, Arturo Evangelista, Laura Dos-Subira, Jose F. Rodriguez-Palomares, Ignacio Ferreira-Gonzalez
Summary: This study investigates the aortic-related risks associated with pregnancy in women with bicuspid aortic valve (BAV) and evaluates changes in aortic diameter during pregnancy. The results show that pregnant women with BAV have a low rate of cardiac complications and aortic complications are rare. However, there is a small but significant increase in aortic diameter during pregnancy.
Article
Cardiac & Cardiovascular Systems
Alan C. Braverman, Eric Mittauer, Kevin M. Harris, Arturo Evangelista, Reed E. Pyeritz, Derek Brinster, Lori Conklin, Toru Suzuki, Christina Fanola, Maral Ouzounian, Edward Chen, Truls Myrmel, Raffi Bekeredjian, Stuart Hutchison, Joseph Coselli, Dan Gilon, Patrick O'Gara, Melinda Davis, Eric Isselbacher, Kim Eagle
Summary: This study found that aortic dissection occurring during pregnancy in women is mainly due to underlying aortopathy conditions, which many were previously unaware of.
Article
Physiology
Qianwen Hou, Guimei Liu, Ning Liu, Honghui Zhang, Zhuoran Qu, Hanbing Zhang, Hui Li, Youlian Pan, Aike Qiao
Summary: This study investigated the impact of valve height on the performance of aortic valve opening and closing, suggesting that smaller H-V is adapted to smaller D-AA and H-V of 14.5 mm enhances repair durability.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Colleen M. Pater, Iris Gutmark-Little, Justin T. Tretter, Lisa J. Martin, Philippe Backeljauw, Nicole M. Brown
Summary: The study focused on describing a cohort of Turner syndrome patients with aortic dilatation, finding that patients with hypertension and meeting multiple dilatation criteria were more likely to receive treatment. Further research is needed to determine the efficacy of medical therapy on dilatation progression.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Health Care Sciences & Services
Olga Irtyuga, Georgy Kopanitsa, Anna Kostareva, Oleg Metsker, Vladimir Uspensky, Gordeev Mikhail, Giuseppe Faggian, Giunai Sefieva, Ilia Derevitskii, Anna Malashicheva, Evgeny Shlyakhto
Summary: This study evaluated the frequency of ascending aortic aneurysm and aortic dilation in patients with cardiovascular diseases, identifying main risk factors depending on aortic valve morphology. Despite a high prevalence of aortic dilation, many patients were unaware of their condition prior to examination. Factors such as age, male sex, aortic valve parameters, blood pressure, and heart conditions were found to be significant in the formation of aortic dilation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Cesare Cuspidi, Rita Facchetti, Michele Bombelli, Gino Seravalle, Guido Grassi, Giuseppe Mancia
Summary: This study investigated the incidence of new-onset aortic root (AR) dilatation in middle-aged adults over a 25-year time period and its correlation with various factors. The results showed that the risk of AR dilatation is not affected by office and out-office blood pressure, but is closely related to baseline AR diameter and the 25-year change in LVMI.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Pediatrics
Pierluigi Zaza, Flavia Indrio, Annalisa Fracchiolla, Matteo Rinaldi, Giovanni Meliota, Alessia Salatto, Antonio Bonacaro, Gianfranco Maffei
Summary: Loeys-Dietz syndrome is a rare genetic disorder with diverse manifestations, diagnosis relies on genetic testing, and early diagnosis is crucial for prognosis.
Article
Cardiac & Cardiovascular Systems
Luna Cavigli, Gian Luca Ragazzoni, Laura Quer, Nicola Cangiano, Alfonso Santoro, Veronica Ferasin, Giulia Elena Mandoli, Maria Concetta Pastore, Giovanni Benfari, Flavio Luciano Ribichini, Marta Focardi, Serafina Valente, Matteo Cameli, Flavio D'Ascenzi
Summary: This study reported the ratio between aortic root diameter and left ventricular diameter in a cohort of healthy athletes, providing additional parameters to confirm the harmonic remodelling in the athlete's heart.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Bastien Poitier, Mourad Amrane, Patrick Bruneval, Paul Achouh
Summary: Hunter syndrome is a rare disease that can lead to glycosaminoglycan accumulation in tissues, affecting multiple organs. Prognosis is mainly influenced by cardiac and respiratory failures. Patients with Hunter syndrome may have a risk of aortic root dilatation, necessitating periodic monitoring with diagnosis based on indexed measures.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Review
Sport Sciences
Flavio D'Ascenzi, Francesca Valentini, Francesca Anselmi, Luna Cavigli, Francesco Bandera, Giovanni Benfari, Antonello D'Andrea, Giovanni Di Salvo, Roberta Esposito, Vincenzo Evola, Alessandro Malagoli, Giulia Elena Mandoli, Ciro Santoro, Maurizio Galderisi, Sergio Mondillo, Matteo Cameli
Summary: This article discusses how to perform a comprehensive echocardiographic examination in athletes with BAV and analyzes the impact of sports practice on patients with BAV. It also summarizes the current recommendations on sports eligibility and disqualification for competitive athletes with BAV.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Caroline Toolan, Shwe Oo, Matthew Shaw, Mark Field, Manoj Kuduvalli, Deborah Harrington, Omar Nawaytou
Summary: Significant progress has been made in the surgical management of aortic complications of Marfan syndrome (MFS) over the past five decades. However, the varying phenotypic expression complicates the anticipation of future aortic events, highlighting the need for targeted operative techniques and surveillance.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Peripheral Vascular Disease
Cesare Cuspidi, Rita Facchetti, Fosca Quarti-Trevano, Raffaella Dell'Oro, Marijana Tadic, Giuseppe Mancia, Guido Grassi
Summary: This study aimed to evaluate the long-term changes in aortic root diameter in a population-based sample, and to explore the demographic and clinical variables independently associated with this dynamic process.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew L. Stone, Michal Schafer, Johannes C. von Alvensleben, Lorna P. Browne, Michael Di Maria, David N. Campbell, James Jaggers, Max B. Mitchell
Summary: This study found that children with repaired truncus arteriosus (TA) have abnormal ascending aortic biomechanical properties and altered left ventricular (LV) function. These changes can be detected by CMR imaging and are different from the control group. Additionally, it was observed that changes in LV function were independent of aortic biomechanical properties.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Junjie Huang, Sze Chai Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: The incidence and mortality rates of childhood cancer vary between different countries. This study used data from the Cancer Incidence in Five Continents Time Trends, Nordic Cancer Registries, Surveillance, Epidemiology and End Results, and WHO Mortality databases to extract the Age-Standardised Rates (ASR) of cancer incidence and mortality among children aged 0-14 years old. The country-specific Average Annual Percentage Change (AAPC) and its corresponding 95% confidence interval (CI) were calculated to determine the epidemiological cancer trend. The results showed that low-income countries had the highest mortality and mortality to incidence ratio of childhood cancer. The incidence of childhood cancer showed an overall increasing trend, while the mortality rate decreased over the past decade.
Article
Oncology
Junjie Huang, Sze Chai Chan, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluated the global incidence, mortality, associated risk factors, and temporal trends of central nervous system (CNS) cancer. The results showed that the overall incidence and mortality rates of CNS cancer were relatively stable globally, but there was an increasing trend in younger male population. Some higher Human Development Index (HDI) countries also showed an increasing mortality rate, indicating a need for further research and exploration of the reasons behind these trends.
Review
Gastroenterology & Hepatology
Junjie Huang, Don Eliseo Lucero-Prisno III, Lin Zhang, Wanghong Xu, Sunny H. H. Wong, Siew C. C. Ng, Martin C. S. Wong
Summary: Globally, gastrointestinal cancers account for over one-fourth of all cancer incidence and one-third of cancer-related mortality. East Asia has the highest burden of gastrointestinal cancers, including stomach, liver, oesophageal, and gallbladder cancers, which is attributed to population growth, aging, and westernization of lifestyles. The increasing incidence of young-onset colorectal cancer is also observed in East Asia. To effectively reduce the burden of gastrointestinal cancers in this region, efforts should be made to modify unhealthy lifestyles, promote vaccination against hepatitis virus, control infections, increase colorectal cancer screening, enhance early cancer detection, and improve cancer survivorship through organized rehabilitation programs.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Oncology
Junjie Huang, Chi-Kwok Chan, Samuel Yee, Yunyang Deng, Yijun Bai, Sze Chai Chan, Man Sing Tin, Xianjing Liu, Veeleah Lok, Lin Zhang, Wanghong Xu, Zhi-Jie Zheng, Jeremy Yuen-Chun Teoh, Chi-Fai Ng, Martin C. S. Wong
Summary: This study is the first comprehensive meta-analysis examining the global prevalence of LUTS. It identified a high level of LUTS prevalence in the general population, with a higher burden in male subjects, older individuals, and the Asian population. There has been an increasing trend in the prevalence of LUTS since the 1990s.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Martin C. S. Wong, Junjie Huang, Harry H. X. Wang, Jinqiu Yuan, Wanghong Xu, Zhi-Jie Zheng, Hao Xue, Lin Zhang, Johnny Y. Y. Jiang, Jason L. W. Huang, Ping Chen, Zhihui Jia, Erlinda Palaganas, Pramon Viwattanakulvanid, Ratana Somrongthong, Andres Caicedo, Maria de Jesus Medina-Arellano, Jill Murphy, Maria B. A. Paredes, Mellissa Withers
Summary: This study investigated individuals' ability to adapt and cope during the COVID-19 pandemic on a global scale, and found an association between low resilience and maladaptive coping behaviors. The study also identified young age, female gender, and poorer financial situation as factors related to low resilience. These findings have important implications for the development of resilience-enhancing interventions.
GLOBALIZATION AND HEALTH
(2023)
Article
Dermatology
Junjie Huang, Sze Chai Chan, Samantha Ko, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluated the global incidence, mortality, risk factors and temporal trends of melanoma skin cancer. The study found that the incidence and mortality rates of melanoma skin cancer have increased globally, with the highest rates in Australia and New Zealand and increasing rates in European countries.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Oncology
Junjie Huang, Erica On-Ting Chan, Xianjing Liu, Veeleah Lok, Chun Ho Ngai, Lin Zhang, Wanghong Xu, Zhi-Jie Zheng, Peter Ka-Fung Chiu, Nikhil Vasdev, Dmitry Enikeev, Shahrokh F. Shariat, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Martin C. S. Wong
Summary: This study evaluates the updated global trends of prostate cancer for individuals and countries in different age groups. The incidence of prostate cancer is rising, especially among the younger population aged 50 or below, while the mortality rate is decreasing.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Obstetrics & Gynecology
Junjie Huang, Wing Chung Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: The objective of this study is to evaluate the global distribution, risk factors, and temporal trends of corpus uteri cancer for different countries and age groups. Data from the Global Cancer Observatory database, Cancer Incidence in Five Continents, and the WHO mortality database were analyzed to calculate age-standardized rates and estimate the annual average percent change. The results showed a substantial increasing trend of corpus uteri cancer, with high-income countries having the highest incidence. Intensive lifestyle modifications are needed, especially among younger women.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Wing Sze Pang, Shui Hang Chow, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluates the global disease burden of mesothelioma and its trends by age, sex, and geographic locations. The findings show a substantial declining incidence trend of mesothelioma in the past decade, possibly related to the restriction of asbestos use in some countries, although an increase was observed in Bulgaria and Korea.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Junjie Huang, Sze Chai Chan, Samantha Ko, Harry H. X. Wang, Jacky Yuan, Wanghong Xu, Zhi-Jie Zheng, Hao Xue, Lin Zhang, Johnny Y. Jiang, Jason L. W. Huang, Ping Chen, Erlinda Palaganas, Pramon Viwattanakulvanid, Ratana Somrongthong, Andres Caicedo, Maria de Jesus Medina-Arellano, Jill Murphy, Maria B. A. Paredes, Mellissa Withers, Martin C. S. Wong
Summary: The COVID-19 pandemic has led to changes in lifestyle habits and mental health outcomes, some of which have contributed to weight gain and an increase in obesity. Factors such as age, education, living environment, employment status, and pre-existing obesity are associated with vulnerability to weight gain. Quarantine, lack of exercise, unhealthy eating habits, and negative thoughts related to COVID-19 are also linked to weight gain. Long-term evaluation of the impact of COVID-19 experiences on health choices is needed, and mental support should be provided to vulnerable groups prone to negative thoughts associated with weight gain.
Review
Surgery
Xiangyi Kong, Li Chen, Zhaohui Su, Ryan J. Sullivan, Steven M. Blum, Zhihong Qi, Yulu Liu, Yujia Huo, Yi Fang, Lin Zhang, Jidong Gao, Jing Wang
Summary: This systematic review investigated the susceptibility of cancer patients to toxicities associated with PD-1/PD-L1 inhibitors and established a clinically relevant landscape of side effects of these inhibitors. The study found that patients treated with PD-1/PD-L1 inhibitors had lower risks for gastrointestinal and hematologic toxicities, but higher risks for respiratory toxicities. In terms of specific side effects, patients treated with PD-1/PD-L1 inhibitors had lower risks for fatigue, asthenia, and peripheral edema, but higher risks for pyrexia, cough, dyspnea, pneumonitis, and pruritus.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Yat Ching Fung, Wing Sze Pang, Fung Yu Mak, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: Vulvar cancer is an uncommon malignancy that poses a public health problem in terms of cost, treatment, and women's health. This study provides a comprehensive analysis of the global burden, risk factors, and temporal incidence trends of vulvar cancer. The incidence of vulvar cancer was higher in Western Europe, Northern America, Northern Europe, Australia and New Zealand, and Eastern Africa. Risk factors such as gross domestic product per capita, Human Development Index, smoking, alcohol drinking, unsafe sex, and HIV infection were associated with higher incidence rates. Overall, the incidence of vulvar cancer is increasing, with different trends observed in older and younger females. The disease burden of vulvar cancer affects women in both developed and developing regions and calls for promotion of smoking cessation, sex education, and HPV vaccination programs. Further studies are needed to explore the reasons behind the increasing trend.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Samantha Ko, Veeleah Lok, Lin Zhang, Xu E. Lin, Don E. Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong, NCD Global Hlth Res Grp, Assoc Pacific Rim Univ APRU
Summary: This study evaluated the global incidence, mortality, risk factors, and temporal trends of lip, oral, and pharyngeal cancer. Results showed that the highest incidence rates were found in Melanesia and South-Central Asia, with mortality rates of 8.2 and 7.5. Risk factors associated with incidence and mortality included HDI, tobacco use, alcohol consumption, poor diet, and chronic health conditions. Overall, global incidence and mortality rates have decreased, but there are significant increases in older age groups and female subjects.
Article
Public, Environmental & Occupational Health
Yongle Zhan, Yawen Wang, Yimin Qu, Lin Zhang, Xuan Liu, Ruiyi Liu, Peng Xue, Jiaxu Wang, Dongxu Qin, Hexin Yue, Canqing Yu, Jun Lyu, Yu Guo, Zhengming Chen, Yu Jiang, Liming Li
Summary: Limited evidence exists on the relationship between pregnancy loss and female-specific cancers in the Chinese population. This report found that terminations were associated with a lower risk of endometrial cancer, while stillbirths were related to a higher risk of cervical cancer. Rural residents with a history of pregnancy loss had increased risks of breast and cervical cancers compared to urban counterparts. A positive graded relationship between live births and pregnancy loss on cervical cancer was observed.
Article
Endocrinology & Metabolism
Junjie Huang, Chun Ho Ngai, Yunyang Deng, Ching Nei Pun, Veeleah Lok, Lin Zhang, Qiang Xu, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluated the incidence and mortality trends of thyroid cancer and compared the global trends among different age groups and sexes. The results showed an increasing incidence of thyroid cancer in most countries, regardless of age groups, especially among young populations in Korea, Poland, and China. Therefore, it highlights the importance of implementing more preventive strategies and avoiding over-diagnosis.
