Article
Biochemistry & Molecular Biology
Vitor Loureiro da Silva, Gustavo Augusto Ferreira Mota, Sergio Luiz Borges de Souza, Dijon Henrique Salome de Campos, Alexandre Barroso Melo, Danielle Fernandes Vileigas, Priscila Murucci Coelho, Paula Grippa Sant'Ana, Carlos Padovani, Ana Paula Lima-Leopoldo, Silmeia Garcia Zanati Bazan, Andre Soares Leopoldo, Antonio Carlos Cicogna
Summary: Aerobic exercise training (AET) can improve heart disease by restoring calcium (Ca2+) handling, optimizing intracellular Ca2+ flow, and attenuating cardiac functional impairment. However, the effects of AET on Ca2+ transit and cardiac function in rats with heart failure caused by aortic stenosis (AoS) remain unclear. This study evaluated the impact of AET on Ca2+ handling and cardiac function in rats with AoS-induced heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Mariana Janini Gomes, Ana Karenina Sabela, Isabele Tiburcio Pecin Ferreira, Sergio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Vitor Loureiro da Silva, Dijon Henrique Salome de Campos, Aline Regina Ruiz Lima, Marianna Rabelo Carvalho, Silmeia Garcia Zanati Bazan, Camila Renata Correa, Antonio Carlos Cicogna, Marina Politi Okoshi, Francis Lopes Pacagnelli
Summary: This study evaluated the influence of aerobic exercise on gene-encoding proteins associated with oxidative stress in the diaphragm muscle of rats with aortic stenosis-induced heart failure. The results showed that aerobic exercise training improved systolic function and reduced biomarkers of oxidative stress. This suggests that aerobic exercise has a positive impact on heart failure.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah Hoedemakers, Jan Verwerft, Yogesh N. Reddy, Robin Delvaux, Sarah Stroobants, Siddharth Jogani, Guido Claessen, Steven Droogmans, Bernard Cosyns, Barry A. Borlaug, Lieven Herbots, Frederik H. Verbrugge
Summary: The study aimed to examine the impact of HFpEF vs. AS lesion severity on various cardiac parameters and exercise capacity. The results showed that a high H2FPEF score was associated with reduced exercise capacity and adverse hemodynamics in patients with moderate to severe AS.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Physiology
Yandong Liu, Jiawei Cai, Lefeng Qu
Summary: The study revealed that carotid occlusion or stenosis in a mouse model may exacerbate the formation of aortic stenosis and promote ventricular remodeling, without impairing systolic function. Carotid atherosclerotic plaque may be a pathogenic factor for aortic stenosis and ventricular remodeling.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ray W. Squires, Amanda R. Bonikowske
Summary: Heart transplantation is the preferred treatment for end-stage chronic heart failure. Although many patients experience improved functional ability after transplantation, they still face the challenges of acute rejection and other comorbidities. Exercise training, recommended before and after transplantation, can improve exercise capacity and skeletal muscle strength without altering immunosuppression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Heather L. Wheat, Savitri Fedson, Biykem Bozkurt, Richard A. Josephson
Summary: Exercise intolerance is common in heart failure patients, and cardiac rehabilitation has shown significant benefits in improving mortality and quality of life. However, the benefits of exercise therapy may vary depending on the underlying disease phenotype.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Julien Ternacle, Asim N. Cheema, Francisco Campelo-Parada, Marina Urena, Gabriela Veiga-Fernandez, Luis Nombela-Franco, Antonio J. Munoz-Garcia, Victoria Vilalta, Ander Regueiro, David del Val, Lluis Asmarats, Maria del Trigo, Vicenc Serra, Guillaume Bonnet, Melchior Jonveaux, Effat Rezaei, Anthony Matta, Dominique Himbert, Jose Maria de la Torre Hernandez, Gabriela Tirado-Conte, Eduard Fernandez-Nofrerias, Pablo Vidal, Fernando Alfonso, Lola Gutierrez-Alonso, Juan Francisco Oteo, Yassin Belahnech, Siamak Mohammadi, Francois Philippon, Thomas Modine, Josep Rodes-Cabau
Summary: This study evaluated the incidence and predictors of heart failure-related death and sudden cardiac death in patients undergoing TAVR. The results showed that heart failure and sudden cardiac death accounted for a significant portion of deaths after TAVR. Several factors, including atrial fibrillation and prior pacemaker, were associated with heart failure-related death, while valve-in-valve TAVR and transarterial nontransfemoral approach were associated with sudden cardiac death.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Johan O. Wedin, Ola Vedin, Sergey Rodin, Oscar E. Simonson, Jonathan Horsne Malmborg, Johan Pallin, Stefan K. James, Frank A. Flachskampf, Elisabeth Stahle, Karl-Henrik Grinnemo
Summary: This study aimed to investigate the differences in preoperative diastolic and systolic function between patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) who have severe isolated aortic stenosis (AS). The results showed that patients with BAV had worse preoperative left ventricular function and an increased risk of postoperative heart failure hospitalization compared with patients with TAV. These findings suggest that patients with BAV might require closer surveillance and possibly earlier intervention.
Review
Medicine, General & Internal
Sahrai Saeed, John B. Chambers
Summary: Exercise testing in patients with aortic stenosis (AS) is safe and feasible, and can aid in evaluating the severity of valve stenosis. It should be routinely used in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu, Pang-Hung Hsu
Summary: This translational research examined the implications of DNA methylation associated with high-intensity interval training (HIIT) on cardiac fibrosis in patients with heart failure (HF). The study found that HIIT can reduce cardiac fibrosis and improve cardiorespiratory fitness. This was confirmed through a variety of tests on HF patients, including cardiovascular magnetic resonance imaging and cardiopulmonary exercise tests, as well as cell experiments and proteomics analysis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Esteban Diaz-Jara, Hugo S. Diaz, Angelica Rios-Gallardo, Domiziana Ortolani, David C. Andrade, Camilo Toledo, Katherin V. Pereyra, Karla Schwarz, Gigliola Ramirez, Fernando C. Ortiz, Marcelo E. Andia, Rodrigo Del Rio
Summary: Enhanced central chemoreflex drive and irregular breathing are characteristic features of heart failure (HF). This study found that HF rats have high levels of ROS in the RTN, which are closely related to the enhanced central chemoreflex and breathing disorders. Exercise training increases antioxidant defense in the RTN, reduces ROS formation, and restores normal central chemoreflex drive and breathing regularity in HF rats.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Guelmisal Gueder, Joana Wilkesmann, Nina Scholz, Robert Leppich, Peter Dueking, Billy Sperlich, Christian Rost, Stefan Frantz, Caroline Morbach, Floran Sahiti, Ulrich Stefenelli, Margret Breunig, Stefan Stoerk
Summary: The study demonstrated that implementing a supervised HF exercise program is feasible, safe, and has the potential to improve quality of life and surrogate markers of HF severity, especially in terms of psychological and social aspects for heart failure patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, Yogesh N. V. Reddy, Amanda Braun, Hidemi Sorimachi, Massar Omar, Dejana Popovic, Alessio Alogna, Michael D. Jensen, Rickey Carter
Summary: This study found that treatment with dapagliflozin can reduce pulmonary capillary wedge pressure (PCWP) at rest and during exercise in patients with HFpEF, and has favorable effects on plasma volume and body weight.
Article
Medicine, Research & Experimental
Giuseppe Potrick Stefani, Lucas Capalonga, Lucas Ribeiro da Silva, Thiago Gomes Heck, Matias Nunes Frizzo, Lucas Machado Sulzbacher, Maicon Machado Sulzbacher, Diovana de Batista, Samlai Vedovatto, Ana Paula Santin Bertoni, Marcia Rosangela Wink, Pedro Dal Lago
Summary: The study found that combined exercise training (CET) with 13-alanine and L-histidine supplementation in rats with heart failure (HF) can improve functional capacity and biochemical variables, reduce oxidative stress and inflammation, and affect mRNA expression of calcium transporters in the skeletal muscle.
Article
Cardiac & Cardiovascular Systems
Njabulo Ngwenyama, Annet Kirabo, Mark Aronovitz, Francisco Velazquez, Francisco Carrillo-Salinas, Ane M. Salvador, Tania Nevers, Venkataraman Amarnath, Albert Tai, Robert M. Blanton, David G. Harrison, Pilar Alcaide
Summary: The study found that TCR antigen recognition increases in the left ventricle as cardiac dysfunction progresses, with a limited repertoire of activated CD4+ T-cell clonotypes identified in the left ventricle. Antigen presentation of endogenous antigens was necessary for the development of cardiac dysfunction, and scavenging IsoLGs reduced TCR activation and prevented cardiac dysfunction. This highlights the important role of reactive oxygen species-induced formation of IsoLG-modified cardiac neoantigens in TCR-dependent CD4+ T-cell activation within the heart.
Article
Biochemistry & Molecular Biology
Tassiana Gutierrez de Paula, Bruna Tereza Thomazini Zanella, Leonardo Nazario de Moraes, Jessica Silvino Valente, Jordana Inacio Nascimento-Oliveira, Edson Assuncao Mareco, Geysson Javier Fernandez, Maeli Dal-Pai-Silva
Summary: The study analyzed the sharing of piRNA clusters among three genotypes and identified 24 piRNA clusters that are common among them. Gene expression analysis revealed differences in the expression of certain piRNAs among the genotypes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Paula A. T. S. Castro, Dafiner H. Machanocker, Genoveva F. Luna, Germanna M. Barbosa, Jonathan E. Cunha, Thiago M. Cunha, Fernando Q. Cunha, Thiago L. Russo, Tania F. Salvini
Summary: This study demonstrates that clinical-like cryotherapy has anti-inflammatory effects on acute knee arthritis and provides protection to neuromuscular junctions and muscle fibers.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Juan Felipe Valdes-Lopez, Geysson J. Fernandez, Silvio Urcuqui-Inchima
Summary: The study reveals that CHIKV infection induces high levels of IL27 in MDMs, promoting pro-inflammatory and antiviral response through activation of TLR1/2-MyD88 and TLR3-TRIF signaling pathways, independent of IFN signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mariana F. Fragoso, Geysson J. Fernandez, Lisa Vanderveer, Harry S. Cooper, Michael Slifker, Margie L. Clapper
Summary: This study explored the miR expression profile of precancerous dysplastic lesions in the AOM/DSS mouse model, identifying early molecular changes associated with colitis-associated colorectal cancer (CAC). A miR signature was discovered that can distinguish inflamed non-neoplastic mucosa from dysplasia, providing novel insight into the development of CAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Leticia Estevam Engel, Francilene Lima Agostinho de Souza, Ines Cristina Giometti, Katashi Okoshi, Thaoan Bruno Mariano, Natalia Zamberlan Ferreira, Dyovana Gomes Pinheiro, Rafael Stuani Floriano, Andreo Fernando Aguiar, Antonio Carlos Cicogna, Ivan Jose Vechetti, Francis Lopes Pacagnelli
Summary: This study evaluated the effects of high-intensity interval training on cardiac structural and functional characteristics in hypertensive rats. The results showed that high-intensity interval training decreased blood pressure, improved cardiac function, and reversed alterations in gene encoding.
Article
Genetics & Heredity
S. S. Cury, J. S. Oliveira, C. A. O. Biagi-Junior, W. A. Silva Jr, P. P. Reis, O. Cabral-Marques, E. N. Hasimoto, P. P. Freire, R. F. Carvalho
Summary: Lung cancer patients with COVID-19 have an increased risk of severe disease and poor outcomes. Analyzing the interactions between SARS-CoV-2 and lung cancer cells may reveal molecular mechanisms associated with COVID-19 development and severity. Transcriptome data analysis showed that lung cancer cells infected with SARS-CoV-2 resembled primary lung tumors more than non-malignant lung tissues. Furthermore, the analysis identified cancer genes BRCA1 and CENPF, which are known or predicted to interact with SARS-CoV-2 proteins, as well as other potential host factors associated with COVID-19 infection and severity.
Article
Geriatrics & Gerontology
Juan Thomaz Gabriel de Souza Ramos, Amanda Gomes Pereira, Felipe Sanches Ferrari, Morganna Freitas Andrade, Caroline Souto de Melo, Paulo Jose Fortes Villas Boas, Tainara F. Felix, Marcio de Carvalho, Mariana Souza Dorna, Paula Schmidt Azevedo, Bethan E. Phillips, Bertha Furlan Polegato, Katashi Okoshi, Silmeia Garcia Zanati Bazan, Sergio Alberto Rupp Paiva, Leonardo Antonio Mamede Zornoff, Patricia P. Reis, Marcos Ferreira Minicucci
Summary: This study identified and compared circulating miRNA levels between frail and non-frail older adults following STEMI, and explored the regulatory miRNA-gene networks and pathways involved in this condition. The results showed that frail patients had higher levels of certain miRNAs, and that these miRNAs were predicted to modulate gene expression associated with aging. Pathway enrichment analyses further revealed specific pathways regulated by miRNA target genes.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Driele B. Santos, Geysson J. J. Fernandez, Luciana M. C. Pardini, Maria Ines M. C. Pardini, Adriana C. C. Ferrasi
Summary: Studying the transcriptome of canine mammary ductal carcinoma can help identify genes and pathways related to human breast cancer, leading to the discovery of biomarkers and therapeutic targets. This study identified 633 downregulated and 573 upregulated genes in carcinoma tissue compared to normal tissue, indicating deregulation in inflammatory, cell differentiation and adhesion, and extracellular matrix maintenance pathways. The differentially expressed genes may indicate disease aggressiveness and prognosis. The canine transcriptome serves as an excellent model for oncology research in both humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paula Grippa Sant'Ana, Loreta Casquel de Tomasi, Gilson Masahiro Murata, Danielle Fernandes Vileigas, Gustavo Augusto Ferreira Mota, Sergio Luiz Borges de Souza, Vitor Loureiro Silva, Livia Paschoalino de Campos, Katashi Okoshi, Carlos Roberto Padovani, Antonio Carlos Cicogna
Summary: In pathological cardiac hypertrophy, the heart's energy metabolism shifts towards glucose dependence due to oxygen deficit activating HIF-1a. This study investigates the early changes and associations between HIF-1a, the glycolytic pathway, and cardiac remodeling from hypertrophy to heart failure. The results show increased left ventricular hypertrophy, diastolic function changes, severe systolic and diastolic dysfunction in heart failure, enhanced HIF-1a and glycolysis, and a shift to anaerobic metabolism from the 6th week onwards.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sarah Santiloni Cury, Diogo de Moraes, Jakeline Santos Oliveira, Paula Paccielli Freire, Patricia Pintor dos Reis, Miguel Luiz Batista Jr, Erica Nishida Hasimoto, Robson Francisco Carvalho
Summary: A prediction model was developed to identify patients with muscle loss in non-small lung cancer. Transcriptome and cellular composition analysis revealed an inflammatory and immunosuppressive tumor microenvironment in patients with low muscle mass.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Vanessa Azevedo Voltarelli, Rodrigo W. Alves W. de Souza, Kenji Miyauchi, Carl J. Hauser, Leo Edmond Otterbein
Summary: Heme is an essential iron-protoporphyrin complex that plays a vital role in various cells and can have both harmful and beneficial effects. It can cause cytotoxicity in tissues and organs through pro-oxidant and pro-inflammatory responses, but it can also initiate specific cellular responses important for survival. This review focuses on heme metabolism and signaling pathways, including synthesis, degradation, scavenging, and its role in trauma and inflammatory diseases like traumatic brain injury, sepsis, cancer, and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Eder Anderson Rodrigues, Aline Regina Ruiz Lima, Mariana Janini Gomes, Lidiane Moreira Souza, Thierres Hernani Dias Pontes, Luana Urbano Pagan, Gilson Masahiro Murata, Felipe Cesar Damatto, Igor Carvalho Depra, Amanda Bergamo Goncalves Castro Rego, David Rafael Abreu Reyes, Leonardo Antonio Mamede Zornoff, Katashi Okoshi, Marina Politi Okoshi
Summary: Exercise plays an important role in preventing and treating cardiac remodeling and heart failure caused by myocardial infarction. This study investigated the effects of resistance exercise on structural, functional, and molecular alterations in infarcted rats. The results showed that resistance exercise improved maximum load-carrying capacity, reduced myocardial oxidative stress, and preserved myocardial metabolism, without changing cardiac structure or left ventricular function in infarcted rats.
Article
Biochemistry & Molecular Biology
Diogo de Moraes, Felippe Mousovich-Neto, Sarah Santiloni Cury, Jakeline Oliveira, Jeferson dos Santos Souza, Paula Paccielli Freire, Maeli Dal-Pai-Silva, Marcelo Alves da Silva Mori, Geysson Javier Fernandez, Robson Francisco Carvalho
Summary: Aging causes changes in body composition, including an increase in visceral fat mass, which is associated with age-related diseases. Visceral fat can affect systemic metabolism by secreting molecules that act in distal tissues, particularly the liver. However, little is known about age-related changes in visceral fat in humans.
Article
Endocrinology & Metabolism
Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi
Summary: This study evaluated the effects of SGLT2 inhibitor dapagliflozin on cardiac remodeling, myocardial function, energy metabolism, and metabolomics in rats with Type 1 DM. Long-term treatment with dapagliflozin attenuated cardiac remodeling, myocardial dysfunction, and contractile reserve impairment in Type 1 diabetic rats.Functional improvement is associated with restored pyruvate kinase and phosphofructokinase activity and attenuated metabolomics changes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)