Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, Research & Experimental
Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim, Soo-Youn Lee
Summary: Proteomic analysis revealed changes in transthyretin and TBG levels in MDD patients, which also changed after antidepressant treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dominika Dudek, Adrian Andrzej Chrobak, Anna Julia Krupa, Aleksandra Gorostowicz, Adrian Gerlich, Andrzej Juryk, Marcin Siwek
Summary: This study aimed to compare the effectiveness and tolerability of SSRIs and trazodone XR in treating MDD. The results showed that trazodone XR was more effective than SSRIs in reducing the severity of depression, anxiety, and insomnia. It also showed potential superiority in reducing anhedonia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychiatry
Qiong Sha, Zach Madaj, Sarah Keaton, Martha L. Escobar Galvis, LeAnn Smart, Stanislaw Krzyzanowski, Asgerally T. Fazleabas, Richard Leach, Teodor T. Postolache, Eric D. Achtyes, Lena Brundin
Summary: Depression during and after pregnancy affects a significant percentage of pregnant women. Inflammatory factors and kynurenine metabolites have the potential to predict the development of depression during pregnancy. Inflammation and kynurenine pathway enzymes could also be considered as therapeutic targets in peripartum depression.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Markus Dold, Marleen Margret Mignon Swoboda, Alexander Kautzky, Joseph Zohar, Daniel Souery, Julien Mendlewicz, Stuart Montgomery, Dan Rujescu, Alessandro Serretti, Siegfried Kasper
Summary: This study compared the sociodemographic and clinical characteristics of MDD patients primarily prescribed SSRIs with those receiving alternative first-line ADs. The results showed that patients prescribed SSRIs had a more favorable profile, with lower odds of unemployment, current severity of depressive symptoms, melancholic features, suicidality, and current inpatient treatment. They were also less likely to receive add-on therapies and had a trend towards higher response rates.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Psychology, Biological
Ingrid Tonhajzerova, Zuzana Visnovcova, Igor Ondrejka, Dana Funakova, Igor Hrtanek, Nikola Ferencova
Summary: This study found that adolescent MDD is associated with cardiovascular dysregulation and early vasculature dysfunction, indicating that adolescence is an important period for early diagnosis and prevention of MDD-linked cardiovascular diseases manifesting in adulthood.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2022)
Article
Psychiatry
Zaiquan Dong, Weihong Kuang, Xiaoling Shen, Liantian Tian
Summary: This study found a correlation between plasma IL-6 levels and treatment outcomes of selective serotonin reuptake inhibitors in patients with major depressive disorder (MDD). Patients with lower baseline IL-6 levels were more likely to respond positively to treatment. A negative correlation was also found between baseline IL-6 levels and the reduction rate of HAMD-17 scores after treatment.
PSYCHIATRY RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Ali Sabbagh Gol, Amir Rezaei Ardani, Seyed Kazem Farahmand, Malihe Dadgarmoghaddam, Vahideh Ghorani, Shima Rezaei, Ali Khorsand
Summary: The study found that the additive effect of acupuncture combined with SSRIs for treating anxiety disorders was significantly better than using SSRIs alone for anti-anxiety therapy. The acupuncture group showed greater improvements in STAI score changes and cortisol level decreases compared to the other groups.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
R. Seiger, G. Gryglewski, M. Kloebl, A. Kautzky, G. M. Godbersen, L. Rischka, T. Vanicek, M. Hienert, J. Unterholzner, L. R. Silberbauer, P. Michenthaler, P. Handschuh, A. Hahn, S. Kasper, R. Lanzenberger
Summary: This study found that rapid WM microstructure adaptations within 1 hour after i.v. SSRI administration precede elevations in mood due to SSRI treatment, adding a new facet to the complex mode of action of antidepressant therapy.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Clinical Neurology
Nisang Chen, Xiaoting Wu, Mingqi Tu, Sangsang Xiong, Junyan Jin, Siying Qu, Shuangyi Pei, Jianqiao Fang, Xiaomei Shao
Summary: This article presents a double-blind, randomized controlled trial on the use of intradermal acupuncture (IA) in treating major depressive disorder (MDD) among adolescents. The study compares the effectiveness of IA combined with selective serotonin reuptake inhibitors (SSRIs) to the use of SSRIs alone or sham intradermal acupuncture combined with SSRIs. Various clinical psychiatric scales will be used to assess the efficacy and safety of IA for MDD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Clinical Neurology
Andreas Buchmann, Christopher Ritter, Sabrina Theresia Muller, Melanie Haynes, Carmen Ghisleni, Ruth Tuura, Gregor Hasler
Summary: Subjects with a history of major depressive episode (MDE) showed significantly reduced respiratory sinus arrhythmia (RSA) compared to those who never experienced depression. Higher RSA was associated with lower anxiety and fear levels, particularly in relation to cardiac symptoms and the fear of dying. Lower RSA was also linked to elevated levels of cytokines and thyroid-stimulating hormone in the serum, suggesting a potential connection between the immune system, vegetative nervous system, and emotional dysregulation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Xiaoting Wu, Mingqi Tu, Nisang Chen, Jiajia Yang, Junyan Jin, Siying Qu, Sangsang Xiong, Zhijian Cao, Maosheng Xu, Shuangyi Pei, Hantong Hu, Yinyan Ge, Jianqiao Fang, Xiaomei Shao
Summary: This study aims to explore the efficacy and cerebral mechanism of intradermal acupuncture for moderate depressive disorder (MDD). Participants will be randomly assigned to a waiting list group, sham intradermal acupuncture group, and active intradermal acupuncture group. Multiple assessment methods will be used to measure the effectiveness after a 6-week intervention and 4-week follow-up. Additionally, selected participants will undergo MRI analysis. If proven effective, intradermal acupuncture may become a routine treatment for MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Caroline Kamp Jorgensen, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen
Summary: The review aims to evaluate the beneficial and harmful effects of antidepressants in treating major depressive disorder, as their clinical significance and potential risks remain uncertain. The findings of this systematic review will inform best practices in the treatment and clinical research of this common and burdensome disorder.
SYSTEMATIC REVIEWS
(2021)
Article
Obstetrics & Gynecology
Emelie Wolgast, Caroline Lilliecreutz, Gunilla Sydsjo, Marie Bladh, Ann Josefsson
Summary: The study found that women with major depressive disorder (MDD) diagnosed before pregnancy and who had used antidepressants before or during pregnancy were at increased risk for adverse obstetric and neonatal outcomes compared to women without MDD. These risks included operative childbirth, neonatal intensive care unit (NICU) admissions, preterm birth, and low birthweight. Women who continued antidepressant medication during pregnancy had somewhat higher risks for adverse outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Rehabilitation
Thea Liljeroos, Soorej Jose Puthoopparambil, John Wallert, Claes Held, Erik M. G. Olsson
Summary: The study aimed to explore the self-perceived cognitive status and cognitive challenges associated with lifestyle changes in cardiac rehabilitation among elderly myocardial infarction (MI) patients (>= 65 years). Further, the study explored coping strategies developed to manage these challenges in the everyday life. By adopting individually tailored interventions and improving healthcare provider continuity and accessibility, cognitive challenges associated with cardiac rehabilitation could be easier to overcome.
DISABILITY AND REHABILITATION
(2022)
Article
Behavioral Sciences
Tove Wahlund, Hugo Hesser, Sean Perrin, Sanna Johansson, Vilgot Huhn, Sara Sorhus, Severin Lindskog, Eva Serlachius, Erik Hedman-Lagerlof, Brjann Ljotsson, Erik Andersson
Summary: This study aimed to examine the efficacy of a simplified online metacognitive intervention in reducing worry, and found a significant reduction in worry severity in the intervention group. Negative beliefs about worry and reductions in depressive symptoms separately mediated changes in worry severity during the intervention, with only negative beliefs about worry remaining significant in a multivariate test.
COGNITIVE BEHAVIOUR THERAPY
(2022)
Article
Psychology, Developmental
Paul Lichtenstein, Magnus Tideman, Patrick F. Sullivan, Eva Serlachius, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: The study found that intellectual disability (ID) aggregates in families, with relatives of ID individuals at increased risk of ID in proportion to their degree of genetic relatedness. Genetic factors play a significant role in the development of ID, while male sex of relatives and maternal line of relationship with proband are associated with higher risk.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Critical Care Medicine
Ellinor Berglund, Erik Olsson, Martin Jonsson, Leif Svensson, Jacob Hollenberg, Andreas Claesson, Per Nordberg, Peter Lundgren, Asa Hogstedt, Mattias Ringh
Summary: The study investigated the emotional responses and levels of wellbeing among lay responders dispatched to out-of-hospital cardiac arrests through smartphone alerts. The results showed that lay responders rated the experience as high-energy and mainly positive, and there was no harm to the responders. The exposed groups had low posttraumatic stress scores and high-level general wellbeing at follow-up.
Article
Cardiac & Cardiovascular Systems
Sophia Humphries, John Wallert, Katarina Mars, Claes Held, Robin Hofmann, Erik M. G. Olsson
Summary: This study investigated the impact of different doses of beta-blockers on health-related quality of life (HRQoL) in patients with myocardial infarction (MI). The results showed no significant difference in HRQoL between patients taking less than 50% and those taking equal to or more than 50% of the target beta-blocker dose, except for a slightly lower EQ-VAS score in the higher dose group.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Article
Hematology
Nina Mogensen, Ella Saaranen, Erik Olsson, Birgitte Klug Albertsen, Paivi M. Lahteenmaki, Ulrika Kreicbergs, Mats Heyman, Arja Harila-Saari
Summary: The treatment of acute lymphoblastic leukaemia has a negative impact on the health-related quality of life (HRQOL) of parents, especially in the mental domain. Mothers are more affected than fathers and may require additional support.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Erik M. G. Olsson, Fredrika Norlund, Elisabet Rondung, Sophia M. Humphries, Claes Held, Patrik Lynga, Jonas Spaak, Orjan Sundin, Runa Sundelin, Philip Leissner, Lena Kovamees, Per Tornvall
Summary: This study aims to evaluate the effectiveness of Internet-based cognitive behavior therapy (CBT) in reducing stress and anxiety in patients with MINOCA or TS. A randomized controlled trial will be conducted on 90 patients, with half receiving 10 weeks of Internet-based CBT and the other half receiving usual care. The main outcomes will be anxiety symptoms and stress levels measured using standardized scales. Long-term follow-up will compare the effects of early intervention and late intervention.
Article
Psychology, Clinical
Elisabet Rondung, Sophia Monica Humphries, Erik Martin Gustaf Olsson, Runa Sundelin, Fredrika Norlund, Claes Held, Jonas Spaak, Per Tornvall, Patrik Lynga
Summary: This study aimed to evaluate the effects of an internet-based intervention on patients with stress and anxiety after myocardial infarction. Through a small-scale single arm study, the feasibility of conducting a large-scale randomized controlled trial (RCT) was demonstrated, with improvements made to the study protocol and intervention.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2022)
Article
Medicine, General & Internal
Rebecca Grudin, Johan Ahlen, David Mataix-Cols, Fabian Lenhard, Eva Henje, Cecilia Mansson, Hanna Sahlin, Maria Beckman, Eva Serlachius, Sarah Vigerland
Summary: The study investigated the feasibility and acceptability of therapist-guided and self-guided internet-delivered behavioural activation (I-BA) as a treatment for adolescent depression. The results indicated that both therapist-guided and self-guided I-BA were acceptable and potentially effective treatments for adolescents with depression.
Article
Behavioral Sciences
Thea Liljeroos, Sophia Humphries, Soorej Jose Puthoopparambil, Fredrika Norlund, Erik M. G. Olsson
Summary: Myocardial infarction (MI) is a major cause of death and disability worldwide. Emotional distress, such as anxiety and depression, is common among MI patients. This study analyzed testimonials from MI patients undergoing internet-based cognitive behavioral therapy (iCBT) and identified six themes related to emotional reactions and strategies for managing emotional distress. The findings suggest that applying a behavioral model to managing emotional distress following MI could be effective.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Medicine, General & Internal
Johan Bengtsson, Erik Olsson, Jonas Persson, Robert Boden
Summary: This study aimed to investigate whether treatment for depression with intermittent theta burst stimulation (iTBS) over the dorsomedial prefrontal cortex (DMPFC) had any effects on heart rate variability (HRV). The results showed that treatment with DMPFC iTBS had neither negative nor positive effects on the cardiac autonomic nervous system.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Psychiatry
Per Gorts, Josephine Savard, Katarina Gorts-Oberg, Cecilia Dhejne, Stefan Arver, Jussi Jokinen, Martin Ingvar, Christoph Abe
Summary: This study aimed to investigate if compulsive sexual behavior disorder (CSBD) is associated with structural brain differences in regions involved in reward processing. The findings showed that CSBD patients had lower cortical surface area in the right posterior cingulate cortex and a negative correlation between the area and CSBD symptom severity. These results contribute to a better understanding of the neurobiological mechanisms underlying CSBD.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Article
Oncology
Rebecca Skog, Claudia Lampic, Erik Olsson, Lena Wettergren
Summary: This study examined the interactive participation and content of a moderated discussion forum within a web-based psychoeducational intervention for young adults diagnosed with cancer and experiencing sexual dysfunction and fertility distress. The posts in the discussion forum were analyzed using thematic analysis, revealing four themes related to participants' experiences of sexuality and fertility after cancer. The majority of intervention participants accessed and found support in the forum, highlighting the importance of incorporating such forums in similar interventions.
Article
Behavioral Sciences
Klara Olofsdotter Lauri, Kristina Aspvall, David Mataix-Cols, Eva Serlachius, Christian Rueck, Erik Andersson
Summary: This study evaluated the initial efficacy, feasibility, and acceptability of an online self-guided cognitive intervention for new parents with distressing unwanted intrusive thoughts (UITs). The intervention significantly reduced distress and impairment associated with UITs post-intervention and at the 1-month follow-up. The intervention was deemed feasible and acceptable by participants. Change in negative appraisals mediated the reduction in UITs. Large-scale trials are needed to further validate these findings.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Public, Environmental & Occupational Health
K. C. Ashish, Sanni Halme, Rejina Gurung, Omkar Basnet, Erik Olsson, Ebba Malmqvist
Summary: This study aims to evaluate the association between the usage of different household cooking fuels and congenital birth defects in Nepal, and investigate the potential modifying effect of air ventilation. The results showed that the usage of polluting fuels for cooking was associated with a higher prevalence of congenital birth defects, while ventilation did not have a significant association.
ARCHIVES OF PUBLIC HEALTH
(2023)
