Review
Nutrition & Dietetics
Chiara Nava, Anna Di Gallo, Andrea Biuso, Irene Daniele, Gianluca Lista, Pasquale Comberiati, Diego Peroni, Gian Vincenzo Zuccotti, Enza D'Auria
Summary: Preterm birth can have long-term consequences on respiratory health. The impact of early-life nutrition on the risk of respiratory morbidities in preterm infants remains uncertain due to conflicting evidence. Further well-designed studies are needed to clarify this relationship.
Article
Immunology
Pablo J. Bertrand, Yaneisi Vazquez, Andrea A. Beckhaus, Liliana A. Gonzalez, Ana Maria Contreras, Marcela Ferres, Oslando Padilla, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno
Summary: The study suggests that IL-8 and IL-33 are significantly increased in lower respiratory tract infections caused by RSV and could be potential biomarkers for clinical severity in children with LRTIs.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Pediatrics
Lihua Yang, Guocheng Zhang, Lusheng Huang, Xiaoling Ren, Yanqi Su, Chengxiu Wang, Yuanbin Shi, Liao Li, Hui Shan, Jing Chen, Jianxin Xiong, Xue Xue, Shaofeng Song, Li Zhao, Shuhua An, Haiming Yu, Hong Cao, Lin Zhao, Ming Li, Xiaocui Sheng, Yajun Wang
Summary: The study found that early use of recombinant human interferon alpha 1b and breastfeeding in infants hospitalized with lower respiratory tract infections can prevent subsequent wheezing. Childhood history of allergy, no use of rhIFN alpha 1b, and living in crowded housing may be risk factors for wheezing. Breastfeeding and hospitalization at age <= 1 year old were identified as protective factors.
JORNAL DE PEDIATRIA
(2021)
Article
Virology
Tatsuya Korematsu, Hiroshi Koga
Summary: This study found that age and airway microbiota are risk factors for transient neutropenia in infants with RSV infection. However, neutropenia does not seem to lead to serious infection or hematological disorders.
Article
Pediatrics
Marina Attanasi, Simone Sferrazza Papa, Annamaria Porreca, Giuseppe F. Sferrazza F. Papa, Paola Di Filippo, Francesca Piloni, Giulia Dodi, Francesco Sansone, Sabrina Di Pillo, Francesco Chiarelli
Summary: This study aimed to evaluate the diagnostic value of lung ultrasound (LUS) in wheezing caused by asthma, asthmatic bronchitis, and pneumonia. The results showed that LUS had high sensitivity and specificity in diagnosing pneumonia and asthmatic bronchitis, which could help clinicians determine the etiology of wheezing in school-aged children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Microbiology
Yu P. Song, Man F. Tang, Agnes S. Y. Leung, Kin P. Tao, Oi M. Chan, Gary W. K. Wong, Paul K. S. Chan, Renee W. Y. Chan, Ting F. Leung
Summary: This case-control study investigated the interaction between CDHR3 genotypes and rhinovirus (RV) species on disease severity in Hong Kong children hospitalized for respiratory tract infection (RTI). There were synergistic effects between RV-C and CDHR3 SNPs for RTI severity, which was mainly driven by RV-C.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Robert G. Feldman, Raffaele Antonelli-Incalzi, Katie Steenackers, Dong-Gun Lee, Alberto Papi, Michael G. Ison, Laurence Fissette, Marie-Pierre David, Celine Marechal, Marie Van der Wielen, Lusine Kostanyan, Veronica Hulstrom
Summary: The study shows that older adults with chronic cardiorespiratory or endocrine/metabolic conditions are more prone to respiratory illnesses caused by RSV. A new vaccine has demonstrated significant efficacy against RSV-related diseases in these high-risk populations. The study evaluated the vaccine efficacy and immunogenicity in participants with coexisting medical conditions.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Lien Anh Ha Do, Elisabeth Vodicka, An Nguyen, Thi Ngoc Kim Le, Thi Thanh Hai Nguyen, Quang Tung Thai, Van Quang Pham, Thanh Uyen Pham, Thu Ngoc Nguyen, Kim Mulholland, Minh Thang Cao, Nguyen Thanh Nhan Le, Anh Tuan Tran, Clinton Pecenka
Summary: This study estimated the costs of respiratory syncytial virus (RSV) infection among children in southern Vietnam and found that it imposes a substantial economic burden.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Alexia Kieffer, Matthieu Beuvelet, Aditya Sardesai, Robert Musci, Sandra Milev, Julie Roiz, Jason K. H. Lee
Summary: Universal immunization with nirsevimab for all infants could greatly reduce the health and economic burden of RSV during their first season, including a decrease in RSV-related illnesses, hospitalizations, and cost savings.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Miao Hong, Ting Xiong, Junmei Huang, Yuanjue Wu, Lixia Lin, Zhen Zhang, Li Huang, Qin Gao, Huanzhuo Wang, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: This study aimed to assess the association between vitamin D supplementation and the risk of lower respiratory tract infection (LRTI) among infants. The study found that vitamin D supplementation was significantly associated with a reduced risk of LRTI in infants, and the risk reduction was linearly related to the supplementation dose.
Article
Microbiology
Jinghua Cui, Yuanyuan Zhang, Hanqing Zhao, Xuemei Sun, Zhen Chen, Qun Zhang, Chao Yan, Guanhua Xue, Shaoli Li, Yanling Feng, Han Liu, Xianghui Xie, Jing Yuan
Summary: The study found a correlation between the lower respiratory tract microbiome in children and allergic respiratory diseases, with significant differences in microbial composition and distribution, and some bacteria showing correlations with clinical indices.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Zhenli Diao, Huiying Lai, Dongsheng Han, Bin Yang, Rui Zhang, Jinming Li
Summary: This study is the first to comprehensively validate the mNGS assay for the diagnosis of lower respiratory infections (LRIs) from bronchoalveolar lavage fluid (BALF). It provides a ready-made example for clinical laboratories to standardize their in-house mNGS assays through the preparation of reference materials and development of comprehensive validation schemes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Mohammad Hussain Alqahtani, Mohammad Faraj Alqahtani, Mohammed Asiri, Saad Alghamdi, Ziyad Alshagawi, Saleh Alzahrani
Summary: The study aims to determine the clinical presentation, past medical history, hospitalization course, and prognosis in children below two years of age who have been hospitalized in the past five years. The results show a significant increase in the length of ICU and ventilator use among females compared to males. Furthermore, infants younger than 12 months account for the majority of ICU admissions.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Multidisciplinary Sciences
Simon Dickinson, Huey Yi Chong, Toby Leslie, Mark Rowland, Kristian Schultz Hansen, Dwayne Boyers
Summary: This study evaluated the cost-effectiveness of POCCRP testing versus current clinical practice in primary healthcare facilities in Afghanistan using a decision tree model. The results predict a reduction in inappropriate antibiotic prescriptions and improved treatment outcomes with POCCRP intervention. The cost-effectiveness of POCCRP tests depends on willingness to pay for reductions in inappropriate antibiotic prescribing.
Article
Medicine, General & Internal
Eun Kyo Ha, Ju Hee Kim, Dawon Park, Eun Lee, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Man Yong Han
Summary: This study aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. The results showed that the presence of benzylmercapturic acid in personal urines was associated with atopic dermatitis and positive SCORAD index values. Additionally, children with high quartile mandelic acid concentration were also associated with atopic dermatitis and positive SCORAD index values.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Allergy
Ju Hee Kim, Eun Kyo Ha, Seung Won Lee, Hye Ryeong Cha, Hey-Sung Baek, Man Yong Han
Summary: This study found that low birth weight, high BMI during childhood, and the interaction between BMI during childhood and weight change during infancy are associated with an increased risk of childhood asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Nutrition & Dietetics
Eun Kyo Ha, Ju Hee Kim, Hey-Sung Baek, Eun Lee, Ji Hyeon Baek, Somin Shim, Young Hyeon Kim, Luis A. Moreno, Seung Won Lee, Man Yong Han
Summary: This longitudinal cohort study found an association between early introduction of complementary foods (before 4 months) and increased BMI in children aged 5-7 years.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Allergy
Ju Hee Kim, Yoon Young Yi, Eun Kyo Ha, Hey Ryung Cha, Man Yong Han, Hey-Sung Baek
Summary: This study evaluated the association between atopic dermatitis (AD) and neurodevelopmental dysfunction in children and found that AD may be associated with an increased risk of neurodevelopmental dysfunction, particularly in the areas of gross and fine motor skills.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Joo Young Song, Hye Ryeong Cha, Seung Won Lee, Eun Kyo Ha, Ju Hee Kim, Man Yong Han
Summary: This study found that the use of general anesthesia and endotracheal intubation in children may increase their risk of developing attention deficit hyperactivity disorder (ADHD) and have negative effects on neurodevelopment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Pediatrics
Eun Kyo Ha, Ju Hee Kim, Hye Ryeong Cha, Won Seok Lee, Seung Won Lee, Man Yong Han
Summary: This study investigated the association between feeding to sleep during infancy and subsequent childhood health burdens, and found that it was related to various adverse health outcomes.
JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Eun Kyo Ha, Ju Hee Kim, Hye Ryeong Cha, Gi Chun Lee, Jeewon Shin, Eun Lee, Won Seok Lee, Eun-Gyong Yoo, Mo Kyung Jung, Man Yong Han
Summary: Using a nationwide database, this study found that congenital hypothyroidism (CH) is associated with neurodevelopmental and growth abnormalities. The study also determined the critical period for intervention. The CH group had a higher risk of neurodevelopmental disorders and poorer neurodevelopmental and growth outcomes. Delayed treatment correlated with worse neurodevelopmental outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Pediatrics
Jin Hee Oh, Man Yong Han
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Review
Pediatrics
Ji Eun Lim, Hye Min Kim, Ju Hee Kim, Hey Sung Baek, Man Yong Han
Summary: This study investigated the association between dyslipidemia and cholesterol levels in children and found that high cholesterol levels may be associated with the development of asthma in children.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Article
Allergy
Ju Hee Kim, Eun Lee, Eun Kyo Ha, Jeewon Shin, Gi Chun Lee, Yeong Ho Rha, Man Yong Han
Summary: This study used national health insurance data to track individuals born in Korea between 2002 and 2003 and found that atopic dermatitis in children can lead to other diseases. The study identified 20 diseases that are associated with a higher risk of atopic dermatitis, and revealed a temporal sequence of interconnected comorbidities, starting with febrile seizures, constipation, and asthma in childhood and progressing to food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.
Article
Allergy
Eun Lee, Ju Hee Kim, Hye Ryeong Cha, Eun Kyo Ha, Jeewon Shin, Won Seok Lee, Seung Won Lee, Man Yong Han
Summary: This study investigated the association between school readiness and atopic dermatitis (AD) in children. The results showed that children with AD have vulnerability in activeness and concentration, affecting their readiness for school.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Ju Hee Kim, Eun Lee, Eun Kyo Ha, Gi Chun Lee, Jeewon Shin, Hey-Sung Baek, Sun-Hee Choi, Youn Ho Shin, Man Yong Han
Summary: By analyzing the feeding patterns of 236,372 infants and their childhood disease burden after 10 years, it was found that feeding patterns in infancy were associated with childhood disease risk.
Article
Nutrition & Dietetics
Yeong-Gwan Im, Man-Yong Han, Hey-Sung Baek
Summary: This study investigated the relationship between serum 25-hydroxyvitamin D levels and temporomandibular disorders (TMDs) using large-scale health data. The results showed that deficient vitamin D levels were associated with an increased risk of TMDs, suggesting that vitamin D deficiency may be a potential risk factor for TMD development.
Article
Chemistry, Medicinal
Ju Hee Kim, Hye Ryeong Cha, Eun Kyo Ha, Ji Hee Kwak, Hakjun Kim, Jeewon Shin, Hye Mi Jee, Man Yong Han
Summary: This study aimed to assess the association between first-generation H1-antihistamine use and cardiovascular events in a pediatric population. The findings showed an increased risk of cardiovascular events in children who were administered first-generation H1-antihistamines.
Review
Pediatrics
Eun Kyo Ha, Ju Hee Kim, Man Yong Han
Summary: Long COVID in children refers to the persistence of signs and symptoms for 4 weeks or even 6 months after the initial infection. It can manifest as respiratory symptoms, neuropsychiatric conditions, and general health issues. The pathophysiology of long COVID in children is still under investigation, but possible mechanisms include viral persistence, autoimmunity, and neuroinflammation. Evaluating respiratory symptoms and mental health problems is crucial in managing long COVID in children.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
