Journal
ACTA OTO-LARYNGOLOGICA
Volume 134, Issue 5, Pages 536-542Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00016489.2013.868603
Keywords
Survival rate; head and neck cancer
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Funding
- Chi Mei Medical Center Research Fund
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Conclusions: Galectin-1 overexpression is significantly correlated with the survival rate of patients with nasopharyngeal carcinoma (NPC). Immunohistochemical analysis of galectin-1 expression might be useful for identifying patients with a high risk of distant metastasis and for prompting timely adjuvant systemic therapy for patients with aggressive NPC. Objectives: We examined the effect of galectin-1 on the survival rate of patients with NPC. Methods: A total of 124 patients diagnosed between 1998 and 2002 with NPC without distant metastasis were enrolled in this single-center historical prospective cohort study. Immunohistochemical analysis was used to correlate the galectin-1 expression score in the cytoplasm and the survival rate of patients with NPC. Results: Patients with NPC who overexpressed galectin-1 in cytoplasm showed more aggressive tumor growth and significantly shorter disease-specific survival (DSS) (p=0.0037) and distant metastasis-free survival (DMFS) (p=0.0006) than patients with NPC who did not overexpress galectin-1. Multivariate analysis showed that galectin-1 overexpression remained prognostically independent for DSS (p=0.031, hazard ratio=1.821), and DMFS (p=0.005, hazard ratio=2.417), together with the advanced III-IV stages.
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