Article
Oncology
Jean-Baptiste Melan, Pierre Philouze, Pierre Pradat, Nazim Benzerdjeb, Jacques Blanc, Philippe Ceruse, Carine Fuchsmann
Summary: This study aimed to assess the impact of surgical resection and free flap reconstruction of soft palate cancer on speech, swallowing, and quality of life. The results showed satisfactory speech and swallowing outcomes post-surgery, with relatively little impact on patient quality of life.
Article
Oncology
Danielle J. Maes, Motaz Alaqeel, Michael Parry, Rajesh Botchu, Vaiyapuri Sumathi, Lee M. Jeys, Jonathan D. Stevenson
Summary: This study aims to describe the oncological outcomes and prognostic factors of haemorrhagic soft-tissue sarcomas (HSTS). The results showed that the median overall survival was 12 months, with a two-year survival rate of 15.9% to 52.9%. Factors associated with improved survival included negative resection margins, radiotherapy, neoadjuvant radiotherapy, and amputation. Local recurrence occurred in 35.3% of surgically treated patients with localized disease. Radiotherapy and negative margins significantly affected local recurrence.
Article
Chemistry, Multidisciplinary
Kazim K. Moncal, Hemanth Gudapati, Kevin P. Godzik, Dong N. Heo, Youngnam Kang, Elias Rizk, Dino J. Ravnic, Hwabok Wee, David F. Pepley, Veli Ozbolat, Gregory S. Lewis, Jason Z. Moore, Ryan R. Driskell, Thomas D. Samson, Ibrahim T. Ozbolat
Summary: The study demonstrates the intra-operative bioprinting of various craniomaxillofacial tissues directly on rats, including bone, skin, and composite tissues. A novel osteogenic hard tissue ink and droplet-based bioprinting technology facilitated substantial bone regeneration and accelerated wound closure in a stratified arrangement. The use of a hybrid approach resulted in significant skin wound closure and bone coverage, showcasing the potential for bioprinting technologies in clinical CMF defect reconstruction.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Oncology
Luis E. Cortina, Daniel J. Moverman, Yinge Zhao, Deborah Goss, Joseph Zenga, Sidharth V. Puram, Mark A. Varvares
Summary: This systematic review investigates the relationship between the extent of tongue resection and functional outcomes in oral tongue cancer. It found that patients with less than 20% tongue resected had better swallowing efficiency and speech intelligibility with non-flap reconstruction, while patients with 40-50% tongue defect had better swallowing function with flap repair. The data for intermediate tongue defects (20-40% resection) was inconclusive. Further research is needed to determine the percentage of tongue resection at which flap reconstruction yields superior functional results in oral tongue cancer.
Article
Medicine, General & Internal
Oliver Ristow, Jan Lukas Birgel, Thomas Rueckschloss, Thomas Held, Kristin Lang, Maximilian Smielowski, Sven Zittel, Julius Moratin, Maximilian Pilz, Michael Engel, Juergen Hoffmann, Karl Semmelmayer
Summary: The study aimed to investigate how tissue injury after irradiation affects the surgical outcomes of patients with osteoradionecrosis of the jaw (ORN). The results showed that soft tissue injury from fibrosis and xerostomia increased the likelihood of treatment failure, while soft tissue reconstruction with a microvascular graft improved therapeutic success.
Article
Microbiology
Yueran Ren, Jingru Liang, Xiao Li, Yiting Deng, Sanping Cheng, Qiheng Wu, Wei Song, Yan He, Jiajia Zhu, Xiaomei Zhang, Hongwei Zhou, Jia Yin
Summary: The study examined the oral microbiome in patients with acute ischemic stroke and found dynamic differences in the oral microbial composition between patients with and without stroke-associated pneumonia (SAP). Patients with SAP were more likely to have lower levels of Streptococcus and higher levels of Actinobacteriota, indicating a potential link to poor clinical outcomes. The findings suggest that the oral microbiota could serve as a non-invasive diagnostic biomarker for predicting illness development and outcomes in SAP patients.
Article
Oncology
Zheng Fang, Hong-yu Shen, Qi Xu, Hong-lei Zhou, Lei Li, Si-Yuan Yang, Zhen Zhu, Jin-hai Tang
Summary: Breast cancer patients with high expression of PUS1 have poor prognosis and shorter survival time. Knockdown of PUS1 suppresses the proliferation, colony formation, and invasion abilities of breast cancer cells. PUS1 may serve as a promising biomarker and treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Charles A. Gusho, Alan T. Blank, Steven Gitelis
Summary: The study compared the outcomes of primary leiomyosarcoma of bone (PLB) and soft tissue leiomyosarcoma (SLMS). It found that radiation and surgery improved disease-specific survival for high-grade SLMS, while wide resection or amputation were positive prognostic factors for PLB. Radiation and chemotherapy were not significant prognostic factors for survival in PLB.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
C. J. H. Kramer, M. P. G. Vreeswijk, B. Thijssen, T. Bosse, J. Wesseling
Summary: The role of pathology in patient management has shifted from retrospective evaluation to prospective outlook. Traditional two-dimensional tissue slides have reached their informational limits, calling for technological innovation to support improved individualized treatment options. This article reviews pioneering work in cancer pathology and discusses exciting new technologies to enhance the prognostic and predictive value of cancer pathology.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Koji Takada, Shinichiro Kashiwagi, Nozomi Iimori, Rika Kouhashi, Akimichi Yabumoto, Wataru Goto, Yuka Asano, Yukie Tauchi, Tamami Morisaki, Kana Ogisawa, Masatsune Shibutani, Hiroaki Tanaka, Kiyoshi Maeda
Summary: This study aimed to investigate the effects of hyperlipidemia treatment on breast cancer patients and its correlation with lymph node metastasis. The results showed that the use of lipophilic statins may be associated with lymph node metastasis, and hyperlipidemia treatment and statin administration can prolong the disease-free survival period of breast cancer patients.
Article
Orthopedics
Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Ryuichi Nakahara, Haruyoshi Katayama, Takuto Itano, Toshifumi Ozaki
Summary: The study aimed to evaluate the oncological and functional outcomes of forearm soft tissue sarcomas (STS). A retrospective analysis of 34 patients who underwent surgical excision for forearm STS was conducted. The results showed that bone resection or major nerve palsy was the only factor that influenced the Musculoskeletal Tumor Society rating scale (MSTS) scores. Reconstruction of the skin and tendon can compensate for function, while careful follow-up is important, especially in patients with myxofibrosarcoma, due to its likelihood of local recurrence.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Surgery
Charles A. Gusho, Linus Lee, Jonathan Guntin, Alan T. Blank
Summary: This study compared the outcomes of patients with undifferentiated pleomorphic sarcoma of soft tissue (UPS-S) and bone (UPS-B). UPS-S patients were older with longer survival, while tumor size may be a factor for UPS-B patients. Further research is needed to determine the optimal treatment for these patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Mohssen Ansarin, Rita De Berardinis, Federica Corso, Gioacchino Giugliano, Roberto Bruschini, Luigi De Benedetto, Stefano Zorzi, Fausto Maffini, Fabio Sovardi, Carolina Pigni, Donatella Scaglione, Daniela Alterio, Maria Cossu Rocca, Susanna Chiocca, Sara Gandini, Marta Tagliabue
Summary: This study found that patients diagnosed with Oral Tongue Squamous Cell Carcinoma at the age of 40 and below have better prognosis. Age was identified as an independent prognostic factor, with older patients in advanced stages having a significantly higher risk of mortality. Additionally, young patients were more likely to receive intensified therapies, contributing to their better overall survival outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David Fadli, Michele Kind, Audrey Michot, Francois Le Loarer, Amandine Crombe
Summary: This study qualitatively and quantitatively depicted the natural changes in MRI presentations of STS prior to medical intervention, investigated their prognostic value, and found associations between these changes and histopathology, as well as patient survival outcomes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Pharmacology & Pharmacy
Mengmeng Liu, Quan Li, Yao Liang
Summary: Several studies have identified pyroptosis as a potential target for cancer treatment. This study specifically focuses on the role of pyroptosis-related genes (PRGs) in soft tissue sarcoma (STS) and evaluates their interactions, biological functions, and prognostic values. Through analysis, a five-gene survival related-risk score is created and validated in different cohorts. A nomogram is also developed to predict prognosis and therapeutic responses, and the study suggests that immunotherapy is more beneficial for patients with minimal risk of PRGs. Additionally, effective chemotherapy and targeted drugs sensitive to high-risk populations are identified.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Otorhinolaryngology
Aude Villepelet, Marine Lefevre, Benjamin Verillaud, Francois Janot, Renaud Garrel, Sebastien Vergez, Chloe Bertolus, Olivier Malard, Ludovic de Gabory, Olivier Mauvais, Bertrand Baujat, S. Albert, G. Andry, E. Babin, C. Bach, J. -M. Badet, C. Badoual, A. C. Baglin, A. Banal, B. Barry, E. Baudin, B. Baujat, R. J. Bensadoun, C. Bertolus, J. -P. Bessede, D. Blanchard, C. Borel, A. Bozorg-Grayeli, R. Breheret, P. Breton, L. Brugel, G. Calais, O. Casiraghi, E. Cassagnau, L. Castillo, P. Ceruse, F. Chabolle, D. Chevalier, J. C. Chobaut, O. Choussy, A. Cosmidis, A. Coste, V. Costes, L. Crampette, V. Darrouzet, P. Demez, P. Dessi, B. Devauchelle, G. Dolivet, F. Dubrulle, S. Duflo, X. Dufour, S. Faivre, N. Fakhry, C. Ferron, F. Floret, L. de Gabory, R. Garrel, L. Geoffrois, L. Gilain, A. Giovanni, A. Girod, B. Guerrier, S. Hans, P. Herman, P. Hofman, M. Housset, R. Jankowski, F. Jegoux, M. Julieron, M. -C. Kaminsky, F. Kolb, J. Lacau St Guily, L. Laccoureye, B. Lallemant, P. Lang, E. Lartigau, J. -P. Lavieille, M. Lefevre, X. Leroy, O. Malard, F. Massip, O. Mauvais, J. -C. Merol, J. Michel, T. Mom, S. Moriniere, E. de Mones, G. Moulin, G. Noel, G. Poissonnet, J. -M. Prades, D. de Raucourt, E. Reyt, C. Righini, Y. Marie Robin, F. Rolland, B. Ruhin, N. Sarroul, P. Schultz, E. Serrano, O. Sterkers, V. Strunski, A. Sudaka, M. Tassart, S. Testelin, J. Thariat, A. Timochenko, B. Toussaint, E. Uro Coste, G. Valette, T. Van den Abbeele, A. Varoquaux, F. Veillon, S. Vergez, M. Wassef
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Gastroenterology & Hepatology
Olivier Bouche, Meher Ben Abdelghani, Jean-Luc Labourey, Simon Triby, Rene-Jean Bensadoun, Thomas Jouary, Gaetan Des Guetz
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Oncology
Jordi Giralt, Yungan Tao, Rolf-Dieter Kortmann, Xavier Zasadny, Jorge Contreras-Martinez, Philippe Ceruse, Fernando Arias de la Vega, Rajesh V. Lalla, Esat Mahmut Ozsahin, Gabor Pajkos, Andrew Mazar, Pierre Attali, Paolo Bossi, Berangere Vasseur, Stephen Sonis, Michael Henke, Rene-Jean Bensadoun
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Editorial Material
Oncology
Rene-Jean Bensadoun, Joel B. Epstein
SUPPORTIVE CARE IN CANCER
(2020)
Review
Biochemistry & Molecular Biology
Reem Hanna, Snehal Dalvi, Rene Jean Bensadoun, Stefano Benedicenti
Summary: This systematic review and meta-analysis found significant efficacy of photobiomodulation therapy (PBMT) in temporomandibular disorder (TMD) compared to control treatment strategies, with PBMT showing significant advantages in pain reduction, pain pressure threshold, and maximum mouth opening. The study also proposed recommendations for PBMT protocols and methodology for future TMD research.
Review
Oncology
Alexandre Bozec, Dorian Culie, Gilles Poissonnet, Francois Demard, Olivier Dassonville
Summary: This review discusses the therapeutic management of patients with oropharyngeal squamous cell carcinoma (OPSCC) and the impact of HPV status on treatment selection. While HPV-positive and HPV-negative OPSCC are recognized as two distinct diseases, the influence of HPV status on treatment management remains unclear and controversial.
Review
Pharmacology & Pharmacy
Reem Hanna, Snehal Dalvi, Rene Jean Bensadoun, Judith E. Raber-Durlacher, Stefano Benedicenti
Summary: The systematic review and meta-analysis found that photobiomodulation therapy has positive effects on patients with neurological primary burning mouth syndrome, despite some biases and heterogeneity in the included studies. Further well-designed and robust randomized controlled trials are warranted to confirm these findings.
Article
Biochemistry & Molecular Biology
Reem Hanna, Rene Jean Bensadoun, Seppe Vander Beken, Patricia Burton, James Carroll, Stefano Benedicenti
Summary: This study evaluated the feasibility and effectiveness of photobiomodulation (PBM) intervention for neuropathic pain. Compared to standard analgesic medication, PBM showed significant advantages in reducing pain, improving quality of life, and enhancing functional activities.
Article
Environmental Sciences
Dorian Culie, Renaud Schiappa, Sara Contu, Boris Scheller, Agathe Villarme, Olivier Dassonville, Gilles Poissonnet, Alexandre Bozec, Emmanuel Chamorey
Summary: The study validated the use of a Deep Learning process based on a neural network for the classification of head and neck surgery patients. The model accurately predicted the pathology involved and showed equivalent or better performances compared to other techniques.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Pierre Mattei, Jocelyn Gal, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Deborah Aloi, Mederic Barret, Inga Safta, Esma Saada, Anne Sudaka, Dorian Culie, Alexandre Bozec
Summary: This study aimed to evaluate the clinical outcomes and predictive factors in locally advanced hypopharyngeal cancer patients undergoing induction chemotherapy-based larynx preservation program. The results showed three- and five-year overall survival rates of 67% and 54%, respectively. T4 tumor stage was the only predictive factor of poor response to chemotherapy. Multivariate analysis revealed that T stage = 4, fewer cycles of chemotherapy, and lack of response to chemotherapy were significantly associated with worse overall survival. Low body mass index before therapy and enteral nutrition during therapy were significantly associated with the severity of dysphagia after treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Juliette Hepburn, Susan Williams-Lockhart, Rene Jean Bensadoun, Reem Hanna
Summary: This study evaluated the effectiveness of local methylene blue photodynamic viral inactivation (MB-PDI) combined with orally ingested methylene blue (MB) and photobiomodulation (PBM) for treating COVID-19. The treatment showed promising results in reducing viral load and improving symptoms, with no significant adverse effects and prevention of long COVID symptoms and reinfection.
Article
Medicine, General & Internal
Dorian Culie, Renaud Schiappa, Tanguy Pace-Loscos, Bruno Guelfucci, Sebastien Vergez, Renaud Garrel, Nicolas Fakhry, Olivier Dassonville, Gilles Poissonnet, Benjamin Lallemant, Anne Sudaka, Esma Saada-Bouzid, Karen Benezery, Stephane Temam, Phillipe Gorphe, Emmanuel Chamorey, Alexandre Bozec
Summary: Nutritional support is crucial for tolerating and completing OPSCC treatment, but the impact of HPV status on nutritional support is debated. This study aimed to evaluate the use of RFT and its prognostic factors in OPSCC patients undergoing radiotherapy. A multicentric retrospective study included all OPSCC patients treated from 2009 to 2014. Multivariate analysis showed that tongue base involvement and concurrent chemotherapy were significantly associated with the use of RFT. HPV status was not a prognostic factor for enteral nutrition during radiotherapy for OPSCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Shahin Tahan Shoushtari, Jocelyn Gal, Emmanuel Chamorey, Renaud Schiappa, Olivier Dassonville, Gilles Poissonnet, Deborah Aloi, Mederic Barret, Inga Safta, Esma Saada, Anne Sudaka, Dorian Culie, Alexandre Bozec
Summary: This study compared the survival outcomes of salvage vs. primary total laryngectomy in patients with locally advanced laryngeal or hypopharyngeal carcinoma and determined their predictive factors. The results showed that salvage TL had significantly worse survival rates than primary TL. The predictive factors identified here should be considered in the therapeutic decision-making, especially for salvage TL patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Roxane Elaldi, Emmanuel Chamorey, Renaud Schiappa, Anne Sudaka, Fabienne Anjuere, Agathe Villarme, Dorian Culie, Alexandre Bozec, Henri Montaudie, Gilles Poissonnet
Summary: This study compared different classification systems for predicting the risk of poor outcomes in patients with high-risk head and neck cutaneous squamous cell carcinoma (HNCSCC) and found that the Brigham and Women's Hospital (BWH) classification was the most appropriate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gregoire D'Andrea, Lun Jing, Isabelle Peyrottes, Jean-Marie Guigonis, Fanny Graslin, Sabine Lindenthal, Julie Sanglier, Isabel Gimenez, Juliette Haudebourg, Clair Vandersteen, Alexandre Bozec, Nicolas Guevara, Thierry Pourcher
Summary: In this study, the researchers evaluated the metabolomic profiles of liquid-based fine-needle aspiration cytology (FNAC) samples to identify a potential molecular diagnostic method for differentiating between malignant and benign thyroid nodules. The study found a promising metabolomic signature that can accurately differentiate papillary thyroid carcinomas (PTCs) from benign thyroid nodules. Further research with larger cohorts is needed to identify more biomarkers and establish more reliable diagnostic signatures.