Article
Neurosciences
Nicholas S. Andresen, Sarah Coreas, Dillan F. Villavisanis, Amanda M. Lauer
Summary: This research examined the pigmentation within temporal bones of mice and humans, revealing an increase in melanin within the stria vascularis with age, but not within the vestibular system. African-American individuals showed higher levels of pigment within the SV and vestibular system in both pediatric and adult populations.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Otorhinolaryngology
Yunqiu Yang, Linda J. Hood, Bradley McPherson
Summary: The study compared cochlear and peripheral neural function across ABO blood groups, finding statistically significant differences in wave I peak-to-peak amplitudes, with group O participants showing reduced wave I amplitudes. Consistently, group O participants also exhibited reduced cochlear microphonic amplitudes and prolonged wave I latencies.
ACTA OTO-LARYNGOLOGICA
(2021)
Article
Biochemical Research Methods
Hannah Ginsberg, Ravinderjit Singh, Hari M. Bharadwaj, Michael G. Heinz
Summary: This study evaluated the feasibility of using a 32-channel rodent EEG mini-cap to improve ABR measures. The results suggest that the mini-cap methodology is more reliable and less variable compared to the conventional subdermal-needle methodology, especially in analyzing ABR thresholds.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Biology
Maria C. Perez-Flores, Eric Verschooten, Jeong Han Lee, Hyo Jeong Kim, Philip X. Joris, Ebenezer N. Yamoah
Summary: Mechanosensation is crucial for hearing, balance, and touch. The auditory system achieves ultrafast speed and high audio-frequency hearing through the interaction between mechanical sensitivity and synaptic responses.
Article
Biology
Elizabeth A. McCullagh, John Peacock, Alexandra Lucas, Shani Poleg, Nathaniel T. Greene, Addison Gaut, Samantha Lagestee, Yalan Zhang, Leonard K. Kaczmarek, Thomas J. Park, Daniel J. Tollin, Achim Klug
Summary: Naked mole-rats living underground have a specialized auditory system and show similar hearing onset to other rodents, but they have developmental differences in brain structure and morphology.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Laura M. Markodimitraki, Inge Stegeman, Hans G. X. M. Thomeer
Summary: This study developed and validated a standardized Patient Reported Outcome Measure (PROM) questionnaire, called COMPASS, for evaluating the awareness of cochlear implant users. The questionnaire showed good validity and reliability, providing a quantitative assessment of patients' awareness and its impact on daily life.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Weiming Hao, Lei Ye, Huiqian Yu, Huawei Li
Summary: This study aimed to evaluate the prognosis of vestibular function in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) and vertigo. The study found that restoration of peripheral vestibular sensory input and central vestibular compensation can occur during the course of ISSNHL with vertigo. However, the recovery rate is better for the semicircular canals than for the otolith organs, and incomplete and in-process restoration of vestibular dysfunction may perturb and delay the establishment of central compensation for balance.
JOURNAL OF NEUROLOGY
(2023)
Article
Chemistry, Physical
Xiaoxuan Tan, Kaijie Wu, Shuang Liu, Yifang Yuan, Chao Chang, Wei Xiong
Summary: This study introduces a minimally invasive technology called terahertz wave modulation that can enhance hearing perception in animals. By modulating the currents in cochlear hair cells, this technique can reversibly increase mechano-electrical transducer currents and voltage-gated K+ currents, resulting in improved hearing sensitivity.
Article
Multidisciplinary Sciences
Tessa R. Sanders, Matthew W. Kelley
Summary: Transcriptional analysis reveals that the afferent innervation of the cochlea goes through a process of splitting and differentiation to generate four transcriptionally distinct subtypes. The initial specification process is genetically controlled and may also be regulated by other transcription factors during subsequent development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Isabel Gugel, Florian Grimm, Philip Hartjen, Maria Breun, Julian Zipfel, Marina Liebsch, Hubert Lowenheim, Ulrike Ernemann, Lan Kluwe, Victor-Felix Mautner, Marcos Tatagiba, Martin Ulrich Schuhmann
Summary: Both BAEP and audiometry are essential in the decision-making process for neuro-oncological treatment of NF2-associated VS, with preoperative BAEP and resection amount significantly influencing postoperative hearing outcome. A prediction model indicates that an increase in BAEP class is associated with an increased risk of postoperative hearing deterioration. Larger resection amounts pose a higher risk compared to smaller resections, emphasizing the importance of careful monitoring and adjustment during surgery.
Review
Neurosciences
Ming Li, Yurong Mu, Hua Cai, Han Wu, Yanyan Ding
Summary: Auditory diseases are significant clinical problems worldwide. Novel materials have the potential to greatly improve wound healing, infection prevention, hair cell regeneration, and functional recovery, but clinical success has been limited.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Constanza Fuentealba Bassaletti, Babette F. van Esch, Jeroen J. Briaire, Peter Paul G. van Benthem, Erik F. Hensen, Johan H. M. Frijns
Summary: The study evaluated the effectiveness of using v-HIT to reduce the need for additional caloric testing in cochlear implant candidates. The newly developed MGS model showed better balance in sensitivity and specificity compared to traditional parameters.
FRONTIERS IN NEUROLOGY
(2021)
Review
Immunology
Grace E. Gregory, Kevin J. Munro, Kevin N. Couper, Omar N. Pathmanaban, David Brough
Summary: Sensorineural hearing loss is the most common type of hearing loss in adults, caused by various factors such as aging, noise exposure, toxins, and cancer. Inflammation, including auto-inflammatory diseases, has been found to contribute to hearing loss. The activation of resident macrophage cells in the inner ear and the NLRP3 inflammasome may play a role in hearing loss. This article discusses the potential of targeting the NLRP3 inflammasome and associated cytokines as therapeutic strategies for sensorineural hearing loss in different conditions.
CLINICAL IMMUNOLOGY
(2023)
Article
Neurosciences
Marijana Sekulic-Jablanovic, Jessica Paproth, Cinzia Sgambato, Giuseppe Albano, Daniel G. Fuster, Daniel Bodmer, Vesna Petkovic
Summary: This study found that the lack or inhibition of NHE6 or NKCC1 affects the permeability of endothelial BLB-derived cells. These findings suggest that NHE6 and NKCC1 could serve as potential targets to modify BLB permeability for drug delivery to the cochlea or to protect the cochlea from ototoxic insults.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Jianxin Bao, Segun Light Jegede, John W. Hawks, Bethany Dade, Qiang Guan, Samantha Middaugh, Ziyu Qiu, Anna Levina, Tsung-Heng Tsai
Summary: This study investigates the feasibility of using curvature quantification to detect cochlear synaptic loss. The results demonstrate that curvature measurement is more sensitive and consistent in identifying cochlear synaptic loss in mice compared to amplitude and latency measurements. Furthermore, different types of ear disorders show distinct changes in curvature profiles.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)