Article
Otorhinolaryngology
Yin Ren, Kareem O. Tawfik, Bill J. Mastrodimos, Roberto A. Cueva
Summary: Radiographic predictors such as tumor size and extension relative to the internal auditory canal play a significant role in hearing preservation after retrosigmoid resection of vestibular schwannomas. Patients with small intracanalicular tumors and good preoperative hearing have the highest rates of hearing preservation, while tumors extending into the cerebellopontine angle may have worse outcomes if they have greater posterior and caudal extension relative to the internal auditory canal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Leonardo Franz, Antonio Mazzoni, Alessandro Martini, Domenico d'Avella, Elisabetta Zanoletti
Summary: This study demonstrates a strong association between the positioning of the craniotomy and the rate of fundus exposure. The findings suggest that the posteromedial edge of the retrosigmoid craniotomy should be located approximately 11 mm posteromedially to the fundus-labyrinth line to maximize the chances of exposing the fundus.
OPERATIVE NEUROSURGERY
(2022)
Article
Clinical Neurology
Ricardo Ramina, Gustavo S. Jung, Felipe Constanzo, Erasmo Barros da Silva Jr
Summary: The study aimed to evaluate the effect of nerve position within the internal auditory canal on preoperative and postoperative cochlear and facial nerve function in patients with intracanalicular vestibular schwannoma. The study found that patients with tumors located between the vestibular and facial-cochlear nerves had worse outcomes in terms of facial nerve function and hearing preservation after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Makoto Hosoya, Takanori Nishiyama, Takeshi Wakabayashi, Marie N. Shimanuki, Hidemi Miyazaki, Hiroyuki Ozawa, Naoki Oishi
Summary: Surgery for vestibular schwannoma can be performed using different techniques, including the middle cranial fossa, suboccipital, translabyrinthine, and retrolabyrinthine approaches. The retrolabyrinthine approach, which preserves the labyrinth, has been modified to achieve a higher hearing preservation rate of 79% in our department. This improvement is considered helpful for hearing preservation.
Article
Clinical Neurology
Luciano Mastronardi, Alberto Campione, Guglielmo Cacciotti, Ettore Carpineta, Carlo Giacobbo Scavo, Raffaele Roperto, Giovanni Stati, Albert A. Sufianov, Karl Schaller
Summary: Microsurgery of vestibular schwannoma in patients aged 40 or less is associated with good functional results and high rates of total or near-total tumor removal. Patients under 30 years of age tend to have larger, more hypervascularized tumors with more bleeding during surgery and worse long-term functional outcomes compared to those in their fourth decade of life. Limited experience suggests that near-total resection should be preferred for very young patients with large, adherent, hypervascularized tumors to maximize resection and preserve function.
NEUROSURGICAL REVIEW
(2022)
Review
Medicine, General & Internal
Makoto Hosoya, Takeshi Wakabayashi, Koichiro Wasano, Takanori Nishiyama, Nobuyoshi Tsuzuki, Naoki Oishi
Summary: This article reviews recent advances in the management and treatment of vestibular schwannoma, particularly in hearing preservation. By improving intraoperative monitoring systems and conducting precise genomic analysis, the treatment of vestibular schwannomas is expected to be improved.
Article
Clinical Neurology
Omid Moshtaghi, Peter R. Dixon, Alexander D. Claussen, Olivia La Monte, Ashley Tadano, Dominique Gillette, Kareem Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: This retrospective study aimed to evaluate the differences in postoperative hearing in patients who underwent immediate versus delayed microsurgical resection of vestibular schwannomas (VS). The results showed that patients who underwent early surgery had a higher hearing preservation rate compared to those who had delayed surgery.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Clinical Neurology
Jia Xian-hao, Gao Zhen, Yuan Ya-sheng, Zhao Wei-dong
Summary: Resection of vestibular schwannomas originating from the inferior vestibular nerve extending into the fundus of the internal auditory canal through the middle cranial fossa approach with endoscopic assistance can facilitate complete removal of the lesion while minimizing the risk of hearing loss and facial paralysis.
WORLD NEUROSURGERY
(2022)
Article
Medicine, Research & Experimental
Katherine P. Wallerius, Robert J. Macielak, Skye K. Lawlor, Christine M. Lohse, Brian A. Neff, Jamie J. Van Gompel, Colin L. W. Driscoll, Michael J. Link, Matthew L. Carlson
Summary: The study showed that tumor size is the strongest predictor of hearing preservation after microsurgical resection of sporadic vestibular schwannomas. Approximately 10% of patients with tumors >= 15 mm of cerebellopontine angle extension will retain serviceable hearing after microsurgery, indicating the importance of preoperative assessment and patient counseling.
Editorial Material
Clinical Neurology
Guilherme H. W. Ceccato, Julia S. de Oliveira, Pedro H. S. Neto, Nick D. de Carvalho, Vinicius N. Coelho, Hugo A. Hasegawa, Albert A. Sufianov, Luis A. B. Borba
Summary: Vestibular schwannomas are a diverse group of tumors that require careful surgical planning to preserve facial nerve function and hearing postoperatively. Microsurgical resection was successful in achieving complete tumor removal, resulting in improved symptoms and absence of new neurologic deficits in follow-up.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Assaf Berger, Juan Diego Alzate, Kenneth Bernstein, Reed Mullen, Sean McMenomey, Daniel Jethanemest, David R. Friedmann, Eric Smouha, Erik P. Sulman, Joshua S. Silverman, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study evaluates hearing outcomes in patients with vestibular schwannoma (VS) during the modern era of cochlear dose restriction. The results show that factors such as age, baseline GR score, cochlear dose, and biological effective dose are correlated with hearing preservation. Increased tumor-free canal space is associated with better outcomes. Furthermore, patients who meet specific criteria have higher hearing preservation rates compared to the rest of the population.
Article
Otorhinolaryngology
Yavor Bozhkov, Julia Shawarba, Julian Feulner, Fabian Winter, Stefan Rampp, Ullrich Hoppe, Arnd Doerfler, Heinrich Iro, Michael Buchfelder, Karl Roessler
Summary: Surgery for small vestibular schwannomas can achieve excellent hearing preservation. Different grading systems have a significant impact on and correlate with postoperative hearing preservation. Tumor size appears to be more important than anatomical relationships.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, General & Internal
Dillon Dejam, Kevin Ding, Courtney Duong, Vera Ong, Isaac Yang
Summary: Vestibular schwannomas are benign tumors of the cerebellopontine angle that can be treated surgically with the goal of preserving facial nerve and hearing function while controlling the tumor. Although the retrosigmoid approach is generally associated with lower hearing preservation rates compared to the middle cranial fossa approach, in certain cases it can lead to significantly improved hearing postoperatively.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Otorhinolaryngology
Naira Mkrtchyan, Lauranne Alciato, Michel Kalamarides, Daniele Bernardeschi, Olivier Sterkers, Isabelle Bernat, Mustapha Smail, Nadya Pyatigorskaya, Ghizlene Lahlou
Summary: This study retrospectively observed 69 patients who underwent resection surgery for non-vestibular schwannoma cerebellopontine angle tumors, and found a significant improvement in hearing after surgery, with 13% of patients achieving auditory recovery even with a conservative surgical approach.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Clinical Neurology
Kareem O. Tawfik, Thomas H. Alexander, Joe Saliba, Yin Ren, Bill Mastrodimos, Roberto A. Cueva
Summary: This retrospective study analyzed adult patients who underwent surgery for vestibular schwannoma between February 2008 and December 2018 at a tertiary referral center. The results showed that preoperative sudden hearing loss can predict the likelihood of hearing preservation after surgery, especially when the cochlear nerve is preserved during the procedure.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Otorhinolaryngology
Elisabeth Mamelle, Benjamin Granger, Olivier Sterkers, Ghizlene Lahlou, Evelyne Ferrary, Yann Nguyen, Isabelle Mosnier
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2020)
Article
Otorhinolaryngology
Sykopetrites Vittoria, Ghizlene Lahlou, Renato Torres, Hannah Daoudi, Isabelle Mosnier, Stephane Mazalaigue, Evelyne Ferrary, Yann Nguyen, Olivier Sterkers
Summary: The study demonstrates that the RobOtol system can be safely used as an assistant device in otological surgeries under clinical conditions, providing support for surgeons and achieving good treatment outcomes.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
I Mosnier, E. Ferrary, K. Aubry, P. Bordure, A. Bozorg-Grayeli, O. Deguine, C. Eyermann, V. Franco-Vidal, B. Godey, N. Guevara, A. Karkas, N. Klopp, M. Labrousse, J-P Lebreton, Y. Lerosey, E. Lescanne, N. Loundon, R. Marianowski, F. Merklen, K. Mezouaghi, T. Mom, S. Moreau, N. Noel-Petroff, C. Parietti-Winkler, P. Piller, C. Poncet, E. Radafy, S. Roman, S. Roux-Vaillard, S. Schmerber, L. Tavernier, E. Truy, C. Vincent, O. Sterkers
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2020)
Article
Otorhinolaryngology
Hannah Daoudi, Renato Torres, Stephane Mazalaigue, Olivier Sterkers, Evelyne Ferrary, Yann Nguyen
Summary: The study aimed to evaluate the forces involved in manual or robot-assisted manipulations of the ossicular chain. The results showed that robot-assisted manipulation was reliable for ossicular chain operations, and the anatomical model demonstrated the need for higher forces for manipulations.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Pharmacology & Pharmacy
Celine Jaudoin, Florence Agnely, Yann Nguyen, Evelyne Ferrary, Amelie Bochot
Summary: Despite the high incidence of inner ear disorders, there are still no dedicated medications on the market. Drug encapsulation into nanocarriers has shown promising results in enhancing drug absorption in the inner ear and improving efficacy in animal models. However, overcoming various challenges is necessary for future clinical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Clinical Neurology
Hannah Daoudi, Ghizlene Lahlou, Renato Torres, Olivier Sterkers, Vincent Lefeuvre, Evelyne Ferrary, Isabelle Mosnier, Yann Nguyen
Summary: This study demonstrated a safe and reliable insertion of different electrode array types with a robot-assisted technique, showing that robotic insertion of straight electrode arrays is less traumatic compared to manual insertion.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Dario Ebode, Fleur Cohen-Aubart, Stephanie Trunet, Evelyne Ferrary, Ghizlene Lahlou, Isabelle Mosnier
Summary: This study reported seven cases of cochlear implantation in four patients with neurosarcoidosis. All patients showed significant improvement in both quiet and noisy environments. Speech performance remained stable over time, even in patients who experienced disease exacerbation, with a follow-up ranging from 4 to 11 years.
AUDIOLOGY AND NEURO-OTOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Renato Torres, Baptiste Hochet, Hannah Daoudi, Fabienne Carre, Isabelle Mosnier, Olivier Sterkers, Evelyne Ferrary, Yann Nguyen
Summary: This study compared the intracochlear trauma produced by teleoperated robotic insertion and automated robotic insertion of electrode arrays. The results showed that the automated robotic insertion technique reduced both trauma and translocations of the array, compared to the teleoperated robotic technique.
AUDIOLOGY AND NEURO-OTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Celine Jaudoin, Fabienne Carre, Maria Gehrke, Audrey Sogaldi, Vincent Steinmetz, Nathalie Hue, Catherine Cailleau, Guillaume Tourrel, Yann Nguyen, Evelyne Ferrary, Florence Agnely, Amelie Bochot
Summary: NAC, as an antioxidant, can reduce damage to auditory cells after cochlear implantation. However, it was found in experiments that NAC-loaded liposomal gel caused hearing loss, possibly due to DiNAC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Surgery
Renato Torres, Hannah Daoudi, Ghizlene Lahlou, Olivier Sterkers, Evelyne Ferrary, Isabelle Mosnier, Yann Nguyen
Summary: This preliminary study evaluated the hearing performance 1 year post-implantation with either manual or robot-assisted insertion of electrode arrays. Restoration of high-frequency thresholds was associated with better speech perception in silence, and robot-assisted insertion resulted in fewer translocated electrodes.
FRONTIERS IN SURGERY
(2021)
Review
Audiology & Speech-Language Pathology
Daniele De Seta, Hannah Daoudi, Renato Torres, Evelyne Ferrary, Olivier Sterkers, Yann Nguyen
Summary: In the past two decades, cochlear implant surgery has evolved into a minimally invasive procedure with the assistance of robotic technology. While robots have improved accuracy and reduced trauma during the procedure, clinical benefits in terms of hearing preservation and speech performance have not been conclusively demonstrated. Further research and development are needed to address issues such as cost and procedure duration in order to make robotic assistance a standard approach for cochlear implantation.
Article
Neurosciences
Ariane Laplante-Levesque, Judy R. Dubno, Isabelle Mosnier, Evelyne Ferrary, Theodore R. McRackan
Summary: This manuscript provides a comprehensive overview of evidence-based best practices in the development, translation, and cultural adaptation of patient-reported outcome measures for adults with hearing impairment. It discusses the case studies of the CIQOL instruments and the ongoing translation of the CIQOL-35 Profile as examples, and explores future trends in hearing-related PROMs. The manuscript concludes with lessons learned from implementation science for the successful integration of PROMs in clinical practice.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Surgery
Marine Veleur, Ghizlene Lahlou, Renato Torres, Hannah Daoudi, Isabelle Mosnier, Evelyne Ferrary, Olivier Sterkers, Yann Nguyen
Summary: The study shows that robot-assisted endoscopy is a safe and reliable tool for different types of middle ear procedures. It combines the advantages of endoscopic exposure with a two-handed technique, and can be used independently for certain middle ear pathologies or in combination with a microscope for lesions extending to the mastoid or petrous apex.
FRONTIERS IN SURGERY
(2021)
Article
Medicine, General & Internal
Ghizlene Lahlou, Hannah Daoudi, Evelyne Ferrary, Huan Jia, Marion De Bergh, Yann Nguyen, Olivier Sterkers, Isabelle Mosnier
Summary: This study aims to identify the suitable candidates for cochlear implantation in prelingual profoundly deaf adults. The results show that after one year, patients in the good performer group showed significant improvements in speech intelligibility, communication, and quality of life, while those in the poor performer group did not show significant changes in auditory performance or quality of life. Preoperative speech production, communication abilities, and word speech intelligibility in best-aided conditions were identified as differences between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Renato Torres, Jean-Yves Tinevez, Hannah Daoudi, Ghizlene Lahlou, Neil Grislain, Eugenie Breil, Olivier Sterkers, Isabelle Mosnier, Yann Nguyen, Evelyne Ferrary
Summary: This study proposes a new method for assessing the position of an electrode array after cochlear implantation, using basilar membrane templates generated from micro-CT and merging the reconstruction with the template. The results show that this adapted template method can accurately determine the position of the electrode array.
JOURNAL OF CLINICAL MEDICINE
(2022)
