Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart

Transient mitochondrial permeability transition mediates excitotoxicity in glutamate-sensitive NSC34 D motor neuron-like cells

(2015) Xiaoyun Liu et al.   EXPERIMENTAL NEUROLOGY

C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

(2014) Suhong Xu et al.   DEVELOPMENTAL CELL

Regulation of metabolism in individual mitochondria during excitation–contraction coupling

(2014) Guohua Gong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cheng et al. reply

(2014) Heping Cheng et al.   NATURE

The ‘mitoflash’ probe cpYFP does not respond to superoxide

(2014) Markus Schwarzländer et al.   NATURE

Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

(2014) En-Zhi Shen et al.   NATURE

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

(2014) Michael O Breckwoldt et al.   NATURE MEDICINE

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

(2013) John W. Elrod et al.   CIRCULATION JOURNAL

OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

(2013) Jaime Santo-Domingo et al.   EMBO JOURNAL

Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity

(2013) Lan Wei-LaPierre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Triggering of Superoxide Flashes by Mitochondrial Ca2+Uniport and Basal Reactive Oxygen Species Elevation

(2013) Tingting Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide constitutes a major signal of mitochondrial superoxide flash

(2013) Xing Zhang et al.   LIFE SCIENCES

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

(2013) Wang Wang et al.   NATURE MEDICINE

Permeability Transition Pore-Mediated Mitochondrial Superoxide Flashes Regulate Cortical Neural Progenitor Differentiation

(2013) Yan Hou et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy

(2012) Andrew M. Walters et al.   CIRCULATION RESEARCH

Physiological Roles of the Permeability Transition Pore

(2012) Catherine Brenner et al.   CIRCULATION RESEARCH

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

(2012) C. G. Tocchetti et al.   DIABETES

Metabolic homeostasis of the heart: Figure 1.

(2012) Robert S. Balaban   JOURNAL OF GENERAL PHYSIOLOGY

The circularly permuted yellow fluorescent protein cpYFP that has been used as a superoxide probe is highly responsive to pH but not superoxide in mitochondria: implications for the existence of superoxide ‘flashes’

(2011) Markus Schwarzländer et al.   BIOCHEMICAL JOURNAL

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals

(2011) Huaqiang Fang et al.   CELL RESEARCH

The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation

(2011) Jennifer R. Hom et al.   DEVELOPMENTAL CELL

Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease

(2011) Lan Wei et al.   FASEB JOURNAL

Reactive oxygen species in cardiovascular disease

(2011) Koichi Sugamura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of the mitochondrial permeability transition by cyclophilin D: Moving closer to F0–F1 ATP synthase?

(2011) Christos Chinopoulos et al.   MITOCHONDRION

Bioenergetic characterization of mouse podocytes

(2010) Yoshifusa Abe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

(2010) John W. Elrod et al.   JOURNAL OF CLINICAL INVESTIGATION

Superoxide Flashes in Mouse Skeletal Muscle Are Produced by Discrete Arrays of Active Mitochondria Operating Coherently

(2010) Sandrine Pouvreau   PLoS One

Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity

(2009) Jie Yan et al.   CIRCULATION

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression

(2008) Zhyldyz Kabaeva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

(2008) Andrey V Kuznetsov et al.   Nature Protocols