Article
Medicine, General & Internal
Hee Jung Son, Young-Hoon Jo, Hyung Seob Ahn, Jooyoung You, Chang-Nam Kang
Summary: This study compared the outcomes and complications of lumbar spinal fusion for degenerative lumbar spinal stenosis in super-elderly patients (80 years and over) with those in elderly patients (65 years and over, and under 80 years). Results showed no significant differences between the two groups in preoperative and postoperative measures, but the super-elderly group had higher K-ODI scores. Postoperative delirium was more common in the super-elderly group, with SE status identified as a risk factor. Overall, spinal fusion surgery is effective for improving quality of life in super-elderly patients with DLSS, but careful perioperative management is necessary to prevent postoperative delirium.
Article
Clinical Neurology
Colin Gold, Emanuel Ray, David Christianson, Brian Park, Ioannis A. Kournoutas, Taimur A. Kahn, Eli A. Perez, Joel I. Berger, Katie Sander, Cassim A. Igram, Andrew Pugely, Catherine R. Olinger, Ryan Carnahan, Pei-fu Chen, Rashmi Mueller, Patrick Hitchon, Matthew A. Howard, Matthew Banks, Robert D. Sanders, Royce W. Woodroffe
Summary: Risk factors for postoperative delirium in older adults undergoing lumbar spinal fusion surgery include advanced age, diabetes, lower preoperative and postoperative hemoglobin, higher ASA grade, greater extent of surgery, and higher postoperative pain scores. Patients with delirium had a higher incidence of postoperative ICU admission, increased length of stay, decreased likelihood of discharge to home, and increased mortality.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Youfeng Guo, Haihong Zhao, Haowei Xu, Huida Gu, Yang Cao, Kai Li, Ting Li, Tao Hu, Shanjin Wang, Weidong Zhao, Desheng Wu
Summary: The preoperative albumin-alkaline phosphatase ratio (AAPR) can predict the severity of disc degeneration and the likelihood of non-fusion in patients with degenerative lumbar diseases undergoing lumbar fusion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Mitchell King-wei Long, Tyler Enders, Dante Leven, Anthony Cappellino
Summary: Spinal implant migration, a rare complication, can be a potentially fatal risk for patients with Marfan syndrome who have undergone spinal fusion surgery.
Article
Multidisciplinary Sciences
Zhi-qiang Fan, Xin-an Yan, Bao-feng Li, Erdong Shen, Xin Xu, Hu Wang, Yan Zhuang
Summary: This study investigated the prevalence of osteoporosis in patients over 50 years old undergoing spine surgery through a systematic review and meta-analysis. The results showed a high prevalence of osteoporosis in patients undergoing spine surgery, especially in females, older individuals, and patients with degenerative scoliosis and compression fractures. Current osteoporosis screening standards may be inadequate, and orthopedic specialists should focus on preoperative screening and treatment of osteoporosis.
Article
Multidisciplinary Sciences
Young Il Won, Chi Heon Kim, Hee-Pyoung Park, Sun Gun Chung, Woon Tak Yuh, Shin Won Kwon, Seung Heon Yang, Chang-Hyun Lee, Yunhee Choi, Sung Bae Park, John M. Rhee, Kyoung-Tae Kim, Chun Kee Chung
Summary: Lumbar decompression may be a recommendable surgical option for certain elderly patients with lumbar spinal stenosis and sagittal imbalance, despite less improvement in leg pain compared to fusion surgery.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Yong-Gang Li, Li-Ping Li, Zhen-Jiang Li, Hui Li, Yuan Li, Qiang Li, Hai-Bo Yang, Jian-Hong Sun, Jin-Shan Sun
Summary: This study aimed to analyze the gait characteristics of elderly patients with lumbar spinal stenosis using an intelligent device for energy expenditure and activity (IDEEA). The results showed that small intermittent claudication was present in all patients, with increased single support time, double support, step duration, and pulling accel, as well as decreased Push off, speed, step length, and Stride length in the experimental group compared to the control group.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Clinical Neurology
Jeremy C. Heard, Nicholas Siegel, Goutham R. Yalla, Mark J. Lambrechts, Yunsoo Lee, Matthew Sherman, Jasmine Wang, Julia Dambly, Sydney Baker, Grace Bowen, John J. Mangan, Jose A. Canseco, Mark F. Kurd, Ian D. Kaye, Alan S. Hilibrand, Alexander R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder
Summary: Older age, lower body mass index, longer operative duration, more levels fused, and lower preoperative hemoglobin levels are independent predictors of requiring a blood transfusion following lumbar spinal fusion.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Anthony L. Mikula, Nikita Lakomkin, Zach Pennington, Ahmad Nassr, Brett Freedman, Arjun S. Sebastian, Mohamad Bydon, Benjamin D. Elder, Jeremy L. Fogelson
Summary: The study showed that significant lordosis correction can be achieved through TLIF surgery in patients with severe positive sagittal balance, with lower postoperative complications.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Xinyu Zhang, Guanjun Wang, Chunlei Niu, Zhengda Kuang, Baogan Peng
Summary: This study investigated the effects of fusion surgery methods on operative time, blood loss, blood transfusion volume, and postoperative drainage volume in patients with lumbar stenosis. The results showed that the posterolateral fusion method had advantages when three or fewer fusion segments required surgery, while the intervertebral fusion method was more suitable for four-segment surgery.
FOLIA NEUROPATHOLOGICA
(2022)
Article
Medicine, General & Internal
Jihye Kim, Tae-Hwan Kim
Summary: This study comprehensively analyzed the risk factors for postoperative deep infection following instrumented spinal fusion surgery for degenerative spinal disease. The results provide clinicians with an acceptable tool for comprehensive risk assessment of postoperative deep infection in patients who will undergo this surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Matthew K. Tobin, Cristian Gragnaniello, Jack Horwitz, Felicia W. Sun, Constantin Schizas, Sergey Neckrysh
Summary: The study compared lumbar canal dimensions in a Chicago population born in two different decades and found that older patients had significantly larger canal area and anterior-posterior diameter compared to younger patients at all lumbar levels. Additionally, there were significant differences in lumbar canal dimensions between ethnicities, and younger generations seemed to have negatively influenced spinal canal growth.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Manuel Moser, Ichiro Okano, Leonardo Albertini Sanchez, Stephan N. Salzmann, Brandon B. Carlson, Dominik Adl Amini, Lisa Oezel, Erika Chiapparelli, Ek T. Tan, Jennifer Shue, Andrew A. Sama, Frank P. Cammisa, Federico P. Girardi, Alexander P. Hughes
Summary: This study found that there are different interactions between psoas and lumbar spine extensor muscles on lumbar lordosis in men and women, resulting in a unique mechanical environment.
Review
Clinical Neurology
John C. Benson, Vance T. Lehman, Arjun S. Sebastian, Noelle A. Larson, Ahmad Nassr, Felix E. Diehn, John T. Wald, Naveen S. Murthy
Summary: This article provides an in-depth overview of post-operative spine imaging, with a focus on differentiating between pseudoarthrosis and arthrodesis. It covers the most common imaging modalities used, expected post-operative findings, imaging findings in pseudoarthrosis, and imaging definitions of fusion.
Article
Clinical Neurology
Ram Kiran Alluri, Basel Sheikh, Jonathan Charles Elysee, Francis Lovecchio, Sachiin Shah, Ananth Punyala, Bryan Ang, Renaud Lafage, Virginie Lafage, Frank Schwab, Han Jo Kim
Summary: This study aimed to analyze if shoulder balance continues to change in the postoperative period in patients undergoing selective lumbar fusion for adult spinal deformity (ASD), and to investigate if shoulder balance correlates with health-related quality of life (HRQOL) outcomes. The results showed that shoulder balance did not significantly change over the postoperative period and demonstrated no correlation with HRQOL scores.
Article
Clinical Neurology
Miao Wang, Cody E. Bunger, Haisheng Li, Ming Sun, Peter Helmig, Gilava Borhani-Khomani, Chun S. Wu, Ebbe S. Hansen, David Choi, Kristian Hoey
Article
Clinical Neurology
Kristian Hoy, Kamilla Truong, Thomas Andersen, Cody Bunger
EUROPEAN SPINE JOURNAL
(2017)
Article
Clinical Neurology
Kestutis Valancius, Ebbe Stender Hansen, Kristian Hoy, Peter Helmig, Bent Niedermann, Cody Bunger
EUROPEAN SPINE JOURNAL
(2013)
Article
Clinical Neurology
Kristian Hoy, Cody Bunger, Bent Niederman, Peter Helmig, Ebbe Stender Hansen, HaiSheng Li, Thomas Andersen
EUROPEAN SPINE JOURNAL
(2013)
Article
Clinical Neurology
A. Christensen, K. Hoy, C. Bunger, P. Helmig, E. S. Hansen, T. Andersen, R. Sogaard
EUROPEAN SPINE JOURNAL
(2014)
Article
Orthopedics
Kristian Hoy, Blazej Grycel, Thomas Andersen, Cody Bunger
JOURNAL OF ORTHOPAEDIC SURGERY
(2019)
Article
Orthopedics
Simon Toftgaard Skov, Haisheng Li, Ebbe Stender Hansen, Kristian Hoy, Peter Helmig, Jan Duedal Rolfing, Cody Bunger
INTERNATIONAL ORTHOPAEDICS
(2020)
Article
Clinical Neurology
Sidsel Fruergaard, Soren Ohrt-Nissen, Frederik Taylor Pitter, Kristian Hoy, Martin Lindberg-Larsen, Soren Eiskjaer, Benny Dahl, Martin Gehrchen
Summary: This study aimed to identify postoperative complications, readmissions, and mortality within 90 days after pediatric spinal deformity surgery. Findings indicate that pain/mobilization issues are the main reason for extended length of stay, while infections unrelated to the surgical site are a common cause of readmission.
Article
Clinical Neurology
Sidsel Fruergaard, Soren Ohrt-Nissen, Frederik Taylor Pitter, Kristian Hoy, Martin Lindberg-Larsen, Soren Eiskjaer, Benny Dahl, Martin Gehrchen
Summary: In this nationwide study, the 2-year revision risk after primary pediatric spinal deformity surgery is 9.2%. Risk factors for revision include congenital deformity, spondylolisthesis, Scheuermann kyphosis, patients with growth-preserving treatment, and higher Charlson comorbidity index. The most common reason for revision is implant failure.
Article
Clinical Neurology
Magnus A. Hvistendahl, Mats Bue, Pelle Hanberg, Alexander Emil Kaspersen, Anne Vibeke Schmedes, Maiken Stilling, Kristian Hoy
Summary: This study aimed to compare the perioperative tissue concentrations of cefuroxime in the anterior and posterior column during lumbar spine surgery. The results showed that the concentration of cefuroxime decreased over time during the surgery. This provides a reference for the dosing regimen in posterior open lumbar spine surgeries.
Article
Orthopedics
Magnus A. Hvistendahl, Pelle Hanberg, Maiken Stilling, Alexander Emil Kaspersen, Kristian Hoy, Mats Bue
Summary: Perioperative cefuroxime concentrations inside a cannulated pedicle screw used in minimally invasive spine surgery were found to be low, while the concentrations in the opposite non-instrumented vertebral pedicle were higher, suggesting the need for additional prophylactic strategies.
Article
Pharmacology & Pharmacy
Alexander Emil Kaspersen, Pelle Hanberg, Magnus A. Hvistendahl, Mats Bue, Anne Vibeke Schmedes, Kristian Hoy, Maiken Stilling
Summary: Optimal antibiotic prophylaxis is crucial to prevent postoperative infection in spinal surgery. We assessed cefuroxime concentrations and fT > MIC of 4 mu g center dot ml(-1) for relevant bacteria in the intrathecal and extrathecal compartments of the lumbar spine. The results showed that fT > MIC for cefuroxime was lower in the intrathecal compartments than in the extrathecal compartment, suggesting a significant effect of the blood-brain barrier.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Bjarne Kuno Moller, Jan Krog, Hans Jurgen Hoffmann, Claus Vinter Bodker Hviid, Mikkel Mylius Rasmussen
Summary: This study compares the feasibility of using cerebrospinal fluid (CSF) and peripheral blood (PB) as sample media for measuring biomarkers in traumatic spinal cord injury (TSCI). The results suggest that GFAP is a potential diagnostic biomarker that can be measured in both CSF and PB.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Jan Krog, Bjarne Kuno Moller, Hans Jurgen Hoffmann, Claus Vinter Bodker Hvlid, Mikkel Mylius Rasmussen
Article
Clinical Neurology
Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Bjarne Kuno Moller, Jan Krog, Claus Vinter Bodker Hviid, Hans Jurgen Hoffmann, Mikkel Mylius Rasmussen
Summary: This study aimed to describe the inflammatory responses and blood-spinal cord barrier (BSCB) integrity in human traumatic spinal cord injury (TSCI). The results showed that TSCI mainly triggers innate inflammatory responses that resolve over time, although some patients still exhibit non-resolving inflammation in the cerebrospinal fluid (CSF). Furthermore, BSCB disruption was observed in some TSCI patients.
ACTA NEUROCHIRURGICA
(2022)