4.5 Article

Impact of instrumentation in lumbar spinal fusion in elderly patients 71 patients followed for 2-7 years

Journal

ACTA ORTHOPAEDICA
Volume 80, Issue 4, Pages 445-450

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.3109/17453670903170505

Keywords

-

Categories

Ask authors/readers for more resources

Background and purpose An increasing number of lumbar fusions are performed using allograft to avoid donor-site pain. In elderly patients, fusion potential is reduced and the patient may need supplementary stability to achieve a solid fusion if allograft is used. We investigated the effect of instrumentation in lumbar spinal fusion performed with fresh frozen allograft in elderly patients. Methods 94 patients, mean age 70 (60-88) years, who underwent posterolateral spinal fusion either non-instrumented (51 patients) or instrumented (43 patients) were followed for 2-7 years. Functional outcome was assessed with the Dallas pain questionnaire (DPQ), the low back pain rating scale pain index (LBPRS), and SF-36. Fusion was assessed using plain radiographs. Results Instrumented patients had statistically significantly better outcome scores in 6 of 7 parameters. Fusion rate was higher in the instrumented group (81% vs. 68%, p = 0.1). Solid fusion was associated with a better functional outcome at follow-up (significant in 2 of 7 parameters). 15 patients (6 in the non-instrumented group and 9 in the instrumented group) had repeated lumbar surgery after their initial fusion procedure. Functional outcome was poorer in the group with additional spine surgeries (significant in 4 of 7 parameters). Interpretation Superior outcomes after lumbar spinal fusion in elderly patients can be achieved by use of instrumentation in selected patients. Outcome was better in patients in which a solid fusion was obtained. Instrumentation was associated with a larger number of additional surgeries, which resulted in a lesser degree of improvement. Instrumentation should not be discarded just because of the age of the patient.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Clinical Neurology

Improved patient selection by stratified surgical intervention: Aarhus Spinal Metastases Algorithm

Miao Wang, Cody E. Bunger, Haisheng Li, Ming Sun, Peter Helmig, Gilava Borhani-Khomani, Chun S. Wu, Ebbe S. Hansen, David Choi, Kristian Hoey

SPINE JOURNAL (2015)

Article Clinical Neurology

Addition of TLIF does not improve outcome over standard posterior instrumented fusion. 5-10 years long-term Follow-up: results from a RCT

Kristian Hoy, Kamilla Truong, Thomas Andersen, Cody Bunger

EUROPEAN SPINE JOURNAL (2017)

Article Clinical Neurology

Failure modes in conservative and surgical management of infectious spondylodiscitis

Kestutis Valancius, Ebbe Stender Hansen, Kristian Hoy, Peter Helmig, Bent Niedermann, Cody Bunger

EUROPEAN SPINE JOURNAL (2013)

Article Clinical Neurology

Transforaminal lumbar interbody fusion (TLIF) versus posterolateral instrumented fusion (PLF) in degenerative lumbar disorders: a randomized clinical trial with 2-year follow-up

Kristian Hoy, Cody Bunger, Bent Niederman, Peter Helmig, Ebbe Stender Hansen, HaiSheng Li, Thomas Andersen

EUROPEAN SPINE JOURNAL (2013)

Article Clinical Neurology

Transforaminal lumbar interbody fusion vs. posterolateral instrumented fusion: cost-utility evaluation along side an RCT with a 2-year follow-up

A. Christensen, K. Hoy, C. Bunger, P. Helmig, E. S. Hansen, T. Andersen, R. Sogaard

EUROPEAN SPINE JOURNAL (2014)

Article Orthopedics

Does transforaminal lumbar interbody fusion produce leg pain?-Results from a RCT

Kristian Hoy, Blazej Grycel, Thomas Andersen, Cody Bunger

JOURNAL OF ORTHOPAEDIC SURGERY (2019)

Article Orthopedics

New growth rod concept provides three dimensional correction, spinal growth, and preserved pulmonary function in early-onset scoliosis

Simon Toftgaard Skov, Haisheng Li, Ebbe Stender Hansen, Kristian Hoy, Peter Helmig, Jan Duedal Rolfing, Cody Bunger

INTERNATIONAL ORTHOPAEDICS (2020)

Article Clinical Neurology

Length of stay, readmission, and mortality after primary surgery for pediatric spinal deformities: a 10-year nationwide cohort study

Sidsel Fruergaard, Soren Ohrt-Nissen, Frederik Taylor Pitter, Kristian Hoy, Martin Lindberg-Larsen, Soren Eiskjaer, Benny Dahl, Martin Gehrchen

Summary: This study aimed to identify postoperative complications, readmissions, and mortality within 90 days after pediatric spinal deformity surgery. Findings indicate that pain/mobilization issues are the main reason for extended length of stay, while infections unrelated to the surgical site are a common cause of readmission.

SPINE JOURNAL (2021)

Article Clinical Neurology

Revision risk after pediatric spinal deformity surgery: a nationwide study with 2-year follow-up

Sidsel Fruergaard, Soren Ohrt-Nissen, Frederik Taylor Pitter, Kristian Hoy, Martin Lindberg-Larsen, Soren Eiskjaer, Benny Dahl, Martin Gehrchen

Summary: In this nationwide study, the 2-year revision risk after primary pediatric spinal deformity surgery is 9.2%. Risk factors for revision include congenital deformity, spondylolisthesis, Scheuermann kyphosis, patients with growth-preserving treatment, and higher Charlson comorbidity index. The most common reason for revision is implant failure.

SPINE JOURNAL (2021)

Article Clinical Neurology

Cefuroxime concentrations in the anterior and posterior column of the lumbar spine - an experimental porcine study

Magnus A. Hvistendahl, Mats Bue, Pelle Hanberg, Alexander Emil Kaspersen, Anne Vibeke Schmedes, Maiken Stilling, Kristian Hoy

Summary: This study aimed to compare the perioperative tissue concentrations of cefuroxime in the anterior and posterior column during lumbar spine surgery. The results showed that the concentration of cefuroxime decreased over time during the surgery. This provides a reference for the dosing regimen in posterior open lumbar spine surgeries.

SPINE JOURNAL (2022)

Article Orthopedics

Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: results from a porcine microdialysis study

Magnus A. Hvistendahl, Pelle Hanberg, Maiken Stilling, Alexander Emil Kaspersen, Kristian Hoy, Mats Bue

Summary: Perioperative cefuroxime concentrations inside a cannulated pedicle screw used in minimally invasive spine surgery were found to be low, while the concentrations in the opposite non-instrumented vertebral pedicle were higher, suggesting the need for additional prophylactic strategies.

ACTA ORTHOPAEDICA (2022)

Article Pharmacology & Pharmacy

Evaluation of cefuroxime concentration in the intrathecal and extrathecal compartments of the lumbar spine-an experimental study in pigs

Alexander Emil Kaspersen, Pelle Hanberg, Magnus A. Hvistendahl, Mats Bue, Anne Vibeke Schmedes, Kristian Hoy, Maiken Stilling

Summary: Optimal antibiotic prophylaxis is crucial to prevent postoperative infection in spinal surgery. We assessed cefuroxime concentrations and fT > MIC of 4 mu g center dot ml(-1) for relevant bacteria in the intrathecal and extrathecal compartments of the lumbar spine. The results showed that fT > MIC for cefuroxime was lower in the intrathecal compartments than in the extrathecal compartment, suggesting a significant effect of the blood-brain barrier.

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Article Clinical Neurology

Glial fibrillary acidic protein is a robust biomarker in cerebrospinal fluid and peripheral blood after traumatic spinal cord injury: a prospective pilot study

Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Bjarne Kuno Moller, Jan Krog, Hans Jurgen Hoffmann, Claus Vinter Bodker Hviid, Mikkel Mylius Rasmussen

Summary: This study compares the feasibility of using cerebrospinal fluid (CSF) and peripheral blood (PB) as sample media for measuring biomarkers in traumatic spinal cord injury (TSCI). The results suggest that GFAP is a potential diagnostic biomarker that can be measured in both CSF and PB.

ACTA NEUROCHIRURGICA (2023)

Article Clinical Neurology

Cerebrospinal fluid and peripheral blood proteomics in Traumatic Spinal Cord Injury: A prospective pilot study

Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Jan Krog, Bjarne Kuno Moller, Hans Jurgen Hoffmann, Claus Vinter Bodker Hvlid, Mikkel Mylius Rasmussen

BRAIN AND SPINE (2022)

Article Clinical Neurology

The inflammatory response and blood-spinal cord barrier integrity in traumatic spinal cord injury: a prospective pilot study

Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Bjarne Kuno Moller, Jan Krog, Claus Vinter Bodker Hviid, Hans Jurgen Hoffmann, Mikkel Mylius Rasmussen

Summary: This study aimed to describe the inflammatory responses and blood-spinal cord barrier (BSCB) integrity in human traumatic spinal cord injury (TSCI). The results showed that TSCI mainly triggers innate inflammatory responses that resolve over time, although some patients still exhibit non-resolving inflammation in the cerebrospinal fluid (CSF). Furthermore, BSCB disruption was observed in some TSCI patients.

ACTA NEUROCHIRURGICA (2022)

No Data Available