Article
Chemistry, Multidisciplinary
Yu Qin, Xue-Bo Hu, Wen-Ting Fan, Jing Yan, Shi-Bo Cheng, Yan-Ling Liu, Wei-Hua Huang
Summary: A stretchable and multifunctional platform integrating 3D cell culture, mechanical loading, and electrochemical sensing has been developed for the first time, showing promising potential in exploring mechanotransduction in 3D cellular systems and engineered tissues. The platform utilizes biomimetic peptide linked gold nanotubes on porous and elastic polydimethylsiloxane to mimic articular cartilage and investigate mechanotransduction pathways in chondrocytes. The results reveal previously unclear mechanisms, such as the rapid activation of nitric oxide signaling by mechanical loading in chondrocytes.
Article
Orthopedics
N. Wang, X. Zhang, B. B. Rothrauff, M. R. Fritch, A. Chang, Y. He, M. Yeung, S. Liu, K. E. Lipa, G. Lei, P. G. Alexander, H. Lin
Summary: This study compares preserved and damaged cartilage in patients with osteoarthritis (OA) and identifies a significant reduction of estrogen receptor alpha (ER alpha) in damaged cartilage. Further investigations reveal that ER alpha plays an important role in mediating chondrocyte phenotype and response to mechanical loading. Inhibiting ER alpha expression enhances chondrocyte senescence and osteoarthritic phenotype. These findings suggest that enhancing ER alpha level may represent a new method to treat osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Engineering, Aerospace
Jianqiang Deng, Xin Li, Zhifang Liu, Zhihua Wang, Shiqiang Li
Summary: This paper investigates the mechanical properties of four types of truss lattices through finite element analysis. The results show that the designed lattices have better performance than the reported ones, particularly in terms of energy absorption and impact resistance.
JOURNAL OF AEROSPACE ENGINEERING
(2022)
Article
Construction & Building Technology
Sanjoli Gupta, Suresh Kumar
Summary: This study focuses on developing a combination of geopolymer materials to stabilize soft soil foundations and analyzes the effects of different parameters on the material's performance. The findings demonstrate the potential of geopolymer materials for stabilizing soft soil and their behavior under long-term cyclic loading.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Materials Science, Biomaterials
Mingsheng Xie, Madalyn Fritch, Yuchen He, Huikang Fu, Yi Hong, Hang Lin
Summary: A newly developed resilient hydrogel for cartilage regeneration was found to be biodegradable and capable of withstanding compressive loads. Human chondrocytes seeded in the hydrogel maintained high viability and underwent robust chondrogenesis upon stimulation, with dynamic compressive loading further promoting cartilage matrix formation. Proteins such as p-Erk, p38 kinases, YAP, RhoA, PIEZO1, and TRPV4 were identified to play key roles in mediating chondrocyte response to dynamic loading.
BIOMATERIALS SCIENCE
(2021)
Article
Multidisciplinary Sciences
Meghana Pendyala, Paige S. Woods, Douglas K. Brubaker, Elizabeth A. Blaber, Tannin A. Schmidt, Deva D. Chan
Summary: The study demonstrates that cyclic loading can modulate the endogenous production of hyaluronan, PRG4, and cytokines from synovial fibroblasts. The concentration of hyaluronan and PRG4 is affected by the magnitude of strain, and different strain levels can result in distinct cytokine profiles.
Article
Orthopedics
Jiajie Yang, Yaqiang Li, Xiaojian Shi, Meihua Shen, Kaibing Shi, Lingjie Shen, Chunxi Yang
Summary: Mechanical strength, pore morphology and size are crucial factors for 3D printed porous titanium scaffolds, with regular hexahedron, regular tetrahedron, and imitation diamond-120 degrees structures showing promising results for large pore sizes and high compressive strength.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Chemistry, Physical
Eusoo Choi, Ha-Vinh Ho, Junwon Seo
Summary: This study investigated the impact behavior of SMA fiber-reinforced mortar through a compressive impact test using the split Hopkinson pressure bar method. The results showed that the appearance of SMA fibers, recovery stress, and composite capacity can increase strain rate. The addition of SMA fibers and recovery stress slightly increased specific energy absorption of the reinforced specimens.
Article
Construction & Building Technology
Xueyuan Yan, Fengxuan Wang, Yihui Luo, Xuhong Liu, Zhengxian Yang, Huimin Mao
Summary: This study investigates the effects of single basalt fiber and basalt-polyethylene hybrid fiber on the impact resistance of concrete. The results show that basalt-polyethylene fiber reinforced concrete exhibits better impact resistance and deformation capability, with improvements in dynamic compressive strength, dynamic compressive toughness, and dynamic growth factor. The addition of basalt fiber and polyethylene fiber plays a buffering role in inhibiting crack propagation and slowing down the damage process.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Computer Science, Artificial Intelligence
Kui Qian, Lei Tian
Summary: In this paper, an embedded Hamiltonian dynamic evolutionary neural network model (EHDN) is proposed to address the limitation of Hamiltonian neural network in processing high-dimensional data with nonobservable physical quantity system. The dynamic physical quantities of high dimensional nonlinear systems are represented using Hamiltonian functions, and a symplectic integrator is designed for time-varying evolution of network features based on Hamiltonian regular equation and variational numerical integration. The EHDN model is embedded in the convolutional neural network (CNN) to simulate the Hamiltonian evolution of convolutional features, achieving improved recognition accuracy and training stability in high-dimensional image classification tasks compared to existing state-of-the-art methods.
APPLIED SOFT COMPUTING
(2023)
Article
Cell Biology
Jacqueline M. Bliley, Mathilde C. S. C. Vermeer, Rebecca M. Duffy, Ivan Batalov, Duco Kramer, Joshua W. Tashman, Daniel J. Shiwarski, Andrew Lee, Alexander S. Teplenin, Linda Volkers, Brian Coffin, Martijn F. Hoes, Anna Kalmykov, Rachelle N. Palchesko, Yan Sun, Jan D. H. Jongbloed, Nils Bomer, Rudolf A. de Boer, Albert J. H. Suurmeijer, Daniel A. Pijnappels, Maria C. Bolling, Peter van der Meer, Adam W. Feinberg
Summary: The role of mechanical forces in shaping the heart is crucial but challenging to study in patients. A new dynamic EHT model was developed, allowing for improved function of wild-type EHTs with dynamic loading. Disease modeling using this dynamic loading strategy was essential for inducing specific disease phenotypes.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Xiuju Wu, Rongfei Wang, Wei Li, Bomin Feng, Weihua Hu
Summary: This study successfully designed a electrocatalyst with precious metal phosphide nanoparticles attached on a carbon cloth matrix, which can efficiently catalyze hydrogen and oxygen evolution reactions, and perform well under ultralow precious metal loading.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
M. S. Irfan, M. A. Ali, T. Khan, R. Umer
Summary: This study reports the thermomechanical response of epoxy/glass fiber composites using embedded reduced Graphene Oxide (rGO) coated glass fabric sensors. It was found that these sensors can detect real-time changes in bending amplitudes and frequencies of the composite structure during operation. Additionally, the glass transition temperature (Tg) of the polymer matrix was successfully monitored. The study also showed that these sensors are capable of simultaneously monitoring small changes in amplitude, frequency, and temperature.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Engineering, Civil
Mohammad Zaid
Summary: This study uses the finite element method to simulate the stability of rock tunnels with varying unconfined compressive strength (UCS) under impact loading, finding a strong relationship between the UCS of rock and the extent of damage produced under different impact loading conditions.
GEOMECHANICS AND ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Ali Reza Torabi, Kazem Hamidi, Behnam Shahbazian, Sergio Cicero, Filippo Berto
Summary: This study provides a comprehensive methodology to determine the fracture loads of polymeric structural components with keyhole notches under compressive loading. Through experimental determination of load-carrying capacity and prediction of critical loads using equivalent material concept, the study successfully estimates the compressive critical stress of two polymers.
APPLIED SCIENCES-BASEL
(2021)
Article
Orthopedics
Susumu Araki, Shinji Imai, Hirohito Ishigaki, Tomohiro Mimura, Kazuya Nishizawa, Hiroaki Ueba, Kousuke Kumagai, Mitsuhiko Kubo, Kanji Mori, Kazumasa Ogasawara, Yoshitaka Matsusue
Article
Cell Biology
Kazuya Nishizawa, Shinji Imai, Tomohiro Mimura, Mitsuhiko Kubo, Susumu Araki, Suguru Shioji, Yoshinori Takemura, Yoshitaka Matsusue
CELL AND TISSUE RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Kousuke Kumagai, Mitsuhiko Kubo, Shinji Imai, Futoshi Toyoda, Tsutomu Maeda, Noriaki Okumura, Hiroshi Matsuura, Yoshitaka Matsusue
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Engineering, Biomedical
Tomohiro Mimura, Shinji Imai, Noriaki Okumura, Liangman Li, Kazuya Nishizawa, Susumu Araki, Hiroaki Ueba, Mitsuhiko Kubo, Kanji Mori, Yoshitaka Matsusue
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2011)
Article
Pharmacology & Pharmacy
Eiji Isoya, Futoshi Toyoda, Shinji Imai, Noriaki Okumura, Kousuke Kumagai, Mariko Omatsu-Kanbe, Mitsuhiko Kubo, Hiroshi Matsuura, Yoshitaka Matsusue
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2009)
Article
Orthopedics
T. Mimura, S. Imai, M. Kubo, E. Isoya, K. Ando, N. Okumura, Y. Matsusue
OSTEOARTHRITIS AND CARTILAGE
(2008)
Article
Rheumatology
Masashi Taniguchi, Yoshinori Hiyama, Tsukasa Kamitani, Mitsuhiko Kubo, Taku Kawasaki, Osamu Wada, Kiyonori Mizuno, Yoshitaka Matsusue
MODERN RHEUMATOLOGY
(2020)
Article
Rheumatology
Kosuke Kumagai, Noriaki Okumura, Yasutaka Amano, Takafumi Yayama, Tomohiro Mimura, Tsutomu Maeda, Mitsuhiko Kubo, Kanji Mori, Richard Barrett-Jolley, Shinji Imai
Summary: Patients with elderly-onset rheumatoid arthritis (EORA) may achieve low disease activity with lower drug dosage compared to those with young-onset rheumatoid arthritis (YORA), showing differences in the type and amount of drugs administered for treatment.
MODERN RHEUMATOLOGY
(2021)
Article
Orthopedics
Mitsuhiko Kubo, Tsutomu Maeda, Kosuke Kumagai, Yasutaka Amano, Taku Kawasaki, Shinji Imai
Summary: This study retrospectively reviewed data from 375 patients undergoing 500 primary TKA procedures, finding that postoperative ROM significantly impacted knee function, and improvement in ROM also significantly affected patient satisfaction.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Mitsuhiko Kubo, Tsutomu Maeda, Kosuke Kumagai, Yasutaka Amano, Hitomi Fujikawa, Eiji Isoya, Shinji Imai
Summary: Neuropathic pain factor was found in 16% of patients and catastrophic thinking in 34% of patients. There were no significant differences in pain intensity and radiographic severity between the two groups. Patients with high pain intensity, especially those with low radiographic severity, exhibited strong catastrophic thinking.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Orthopedics
Noriaki Okumura, Taku Kawasaki, Mitsuhiko Kubo, Takafumi Yayama, Tomohiro Mimura, Kosuke Kumagai, Tsutomu Maeda, Shinji Imai
JOURNAL OF ORTHOPAEDIC SURGERY
(2020)
Review
Medicine, Research & Experimental
Mitsuhiko Kobo, Kosei Ando, Tomohiro Mimura, Yoshitaka Matsusue, Kanji Mori
Article
Orthopedics
Mitsuhiko Kubo, Shinji Imai, Mineko Fujimiya, Eiji Isoya, Kosei Ando, Tomohiro Mimura, Yoshitaka Matsusue
Article
Orthopedics
S. Imai, E. Isoya, M. Kubo, N. Kodama, Y. Matsusue
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME
(2007)