Article
Biotechnology & Applied Microbiology
Hongwei Xu, Huanhuan Luo, Jiayu Chen, Gang Chen, Xiaohua Yu, Zhaoming Ye
Summary: In this study, a mineral-coated microparticle-hydrogel system is developed for the controlled release and optimized delivery of BMP-2, which shows significant therapeutic effects in treating large bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Junhyung Kim, Seoyun Lee, Yonghyun Choi, Jonghoon Choi, Byung-Jae Kang
Summary: BMP-2 encapsulated alginate microbeads (AM) and VEGF-adsorbing Apt-HA were used to enhance bone regeneration, with AM showing sustained release of BMP-2. The combination of BMP-2-encapsulated Apt-HA + AM showed significantly improved bone regeneration.
Article
Biochemistry & Molecular Biology
Yi-ding Zhang, Ao-bo Ma, Lu Sun, Jun-duo Chen, Guang Hong, Hong-kun Wu
Summary: This study explores an easy and sound way to modify the biological behavior of microspheres for bone tissue regeneration. Nanoclay can successfully sediment on the surface of microspheres, binding with either positively or negatively charged proteins. These properties facilitate cell proliferation and minimize the use of BMP-2.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Julius Sundermann, Steffen Sydow, Laura Burmeister, Andrea Hoffmann, Henning Menzel, Heike Bunjes
Summary: This study investigated the release performance of BMP-2 from PCL fiber mat-based implant prototypes coated with chitosan nanogel, highlighting the significant effects of chitosan and solubilizing additives on the recovery rate of BMP-2 in in vitro release experiments.
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Tianyi Bao, Zheng Zhou, Peng Gao, Xiaohan Dong, Jian Chen, Shujie Zhao, Pingsheng Liu, Guoyong Yin
Summary: This study designed a multilayer polyelectrolyte coating that can promote the integration of metallic implants with bone and possess antibacterial properties. Stable coatings were constructed on titanium alloy substrates using a layer-by-layer technology, allowing for the sustained release of bone morphogenetic protein 2 and promotion of cell differentiation. Additionally, the polycationic component in the coating significantly improved the antibacterial properties of the titanium alloy surface.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Weiguo Zhu, Chao Kong, Fumin Pan, Miao Ouyang, Kang Sun, Shibao Lu
Summary: This study aimed to investigate the efficacy of CBD-BMP-2 in treating lumbar inter-transverse defects in aged rats with osteopenia and explore the potential of platelet-rich plasma to enhance osteogenesis. In vitro experiments demonstrated the angiogenic and osteogenic effects of platelet-rich plasma and CBD-BMP-2. In vivo experiments showed promising results in promoting lumbar inter-transverse fusion and improving bone healing, especially when combining CBD-BMP-2 with platelet-rich plasma.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Jonathan Dorogin, Henry B. B. Hochstatter, Samantha O. O. Shepherd, Justin E. E. Svendsen, Morrhyssey A. A. Benz, Andrew C. C. Powers, Karly M. M. Fear, Jakob M. M. Townsend, James S. S. Prell, Parisa Hosseinzadeh, Marian H. H. Hettiaratchi
Summary: By using yeast surface display, unique BMP-2-specific affibodies were identified to modulate the release and activity of BMP-2, offering a promising approach for controlling BMP-2 delivery in clinical applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ruonan Zhang, Jun-Ichiro Jo, Ryuhei Kanda, Aki Nishiura, Yoshiya Hashimoto, Naoyuki Matsumoto
Summary: The study modified the surface of polyetheretherketone (PEEK) with sandblasting and polydopamine (PDA) to incorporate a gelatin hydrogel, enabling sustained release of growth factors and osteogenic differentiation of stem cells. The success of gelatin hydrogel binding and degradation with PEEK (GPEEK) was confirmed, along with mineralization in simulated body fluid. The sustained release of bone morphogenetic protein (BMP)-2 in GPEEK led to osteogenic differentiation of human mesenchymal stem cells (hMSCs). PEEK with a gelatin hydrogel incorporating BMP-2 shows promise as a substrate for bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Sihan Lin, Shi Yin, Junfeng Shi, Guangzheng Yang, Xutao Wen, Wenjie Zhang, Mingliang Zhou, Xinquan Jiang
Summary: In this study, the dose of bone morphogenetic protein-2 (BMP-2) was reduced and its safety and efficacy were improved through the regulation of magnesium ion (Mg2+). Magnesium ion enhanced cellular bioenergetic levels and the osteoinductivity of BMP-2. A co-delivery system, fabricated using microfluidic and 3D printing technologies, was able to rapidly and robustly induce bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Gaoli Xu, Chenxi Shen, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu
Summary: This study synthesized a novel biomimetically-precipitated nanocrystalline calcium phosphate (BpNcCaP) with internally incorporated bone morphogenetic protein-2 (BpNcCaP + BMP-2), demonstrating its potential application in repairing large-volume bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xianggang Wang, Zhengyan Li, Zhonghan Wang, He Liu, Yutao Cui, Yuzhe Liu, Ming Ren, Hongsheng Zhan, Zuhao Li, Minfei Wu, Jincheng Wang
Summary: The study developed a thermosensitive hydrogel loaded with BMP-2 and OPG to promote bone formation and inhibit osteoclast activity, which was then used to construct 3D-printed composite scaffolds. These scaffolds facilitated osteogenic differentiation, reduced osteoclastic activation, and improved bone ingrowth and osseointegration through sustained release of BMP-2 and OPG.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Thomas Fuchs, Josef Stolberg-Stolberg, Philipp A. Michel, Patric Garcia, Susanne Amler, Dirk Wahnert, Michael J. Raschke
Summary: The study evaluates the effectiveness of rhBMP-2 treatment on long bone non-unions, showing significantly faster bone healing and higher union rates after rhBMP-2 application. Femoral and tibial non-unions in particular seem to benefit from rhBMP-2 application.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Adrien Nizet, Etienne Cavalier, Peter Stenvinkel, Mathias Haarhaus, Per Magnusson
CLINICA CHIMICA ACTA
(2020)
Review
Urology & Nephrology
Mathias Haarhaus, Dean Gilham, Ewelina Kulikowski, Per Magnusson, Kamyar Kalantar-Zadeh
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2020)
Article
Endocrinology & Metabolism
Riikka E. Makitie, Anders Kampe, Alice Costantini, Jessica J. Alm, Per Magnusson, Outi Makitie
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Michael P. Whyte, Nina S. Ma, Steven Mumm, Gary S. Gottesman, William H. McAlister, Angela R. Nenninger, Vinieth N. Bijanki, Karen L. Ericson, Per Magnusson
Article
Endocrinology & Metabolism
Lisa Johansson, Daniel Sundh, Per Magnusson, Komagal Rukmangatharajan, Dan Mellstrom, Anna G. Nilsson, Mattias Lorentzon
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
B. A. M. Larsson, L. Johansson, H. Johansson, K. F. Axelsson, N. Harvey, L. Vandenput, P. Magnusson, E. McCloskey, E. Liu, J. A. Kanis, D. Sundh, M. Lorentzon
Summary: The TUG test predicts the risk of major osteoporotic fracture and hip fracture independently of clinical risk factors and bone mineral density. A slow TUG time is associated with an increased fracture risk, even after adjusting for clinical risk factors and femoral neck BMD.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Anna Svedlund, Bojan Tubic, Anders Elfvin, Per Magnusson, Diana Swolin-Eide
Summary: This study investigated the potential influence of the FTO gene on body mass and composition in women with anorexia undergoing nutrition therapy. The results showed significant differences in BMI, fat mass, and fat/muscle area ratio among different FTO genotypes during treatment. However, the study did not find evidence to support the need for personalized nutrition therapy based on FTO genotype.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Mathias Haarhaus, Anders Fernstrom, Abdul Rashid Qureshi, Per Magnusson
Summary: Studies have found that in patients with chronic kidney disease (CKD), serum B1x is associated with improved survival, changes in abdominal aortic calcification score, and aortic pulse wave velocity (PWV). Patients with B1x as an indicator have lower bone turnover, suggesting a reduced cardiovascular risk profile.
Article
Pediatrics
Carin Skogastierna, Anders Elfvin, Sverker Hansson, Per Magnusson, Diana Swolin-Eide
Summary: The study found that Swedish children born before 28 gestational weeks have an increased risk of renal impairment, which may impact their health. It is recommended to assess the kidney function of these individuals at least once during adolescence, as well as conduct further investigations and management.
Review
Biochemistry & Molecular Biology
Ahmed Omran, Diana Atanasova, Filip Landgren, Per Magnusson
Summary: This article reviews recent progress in the study of SOST gene, including the regulation pathways, structural and functional properties of sclerostin, and its pathophysiology. It also introduces the development of new assay methods and the importance of standardization work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Mathias Haarhaus, Giuseppe Cianciolo, Simona Barbuto, Gaetano La Manna, Lorenzo Gasperoni, Giovanni Tripepi, Mario Plebani, Maria Fusaro, Per Magnusson
Summary: This narrative review summarizes recent clinical investigations and mechanisms linking alkaline phosphatase (ALP) and bone alkaline phosphatase (BALP) to inflammation, metabolic syndrome, vascular calcification, cardiovascular disease, and mortality. Further discussions include the association between ALP, vitamin K, bone metabolism, and fracture risk in patients with chronic kidney disease (CKD), as well as advancements in pharmacological strategies to modulate ALP expression in CKD-mineral and bone disorder (CKD-MBD).
Article
Oncology
Annika Svanstrom Rojvall, Christian Buchli, Maria Saaf, Per Magnusson, Angelique Floter Radestad, Anna Martling, Josefin Segelman
Summary: This study investigated the association between pelvic radiotherapy (RT) and changes in serum bone biomarkers in women with rectal cancer. The results showed that preoperative RT was associated with an increase in the formation marker PINP. Additionally, radiation-induced bone injuries were detected in some participants, which were associated with higher levels of BALP.
Article
Endocrinology & Metabolism
Anna Svedlund, Cecilia Pettersson, Bojan Tubic, Lars Ellegard, Anders Elfvin, Per Magnusson, Diana Swolin-Eide
Summary: This study aims to investigate the effects of anorexia nervosa (AN) on bone health and the long-term effects of bone and biomarkers in AN patients. The findings highlight the importance of early detection and organized long-term follow-up of bone health in young women.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Pediatrics
Anna-Karin Kroksmark, Lars Alberg, Mar Tulinius, Per Magnusson, Ann-Charlott Soderpalm
Summary: This study investigated bone health in children and adolescents with spinal muscular atrophy (SMA) over a two-year period, and found that all patients had low bone mineral density levels. The study also found a significant correlation between motor function and bone density. Furthermore, the nusinersen treatment group showed a positive development in bone mass.
Article
Multidisciplinary Sciences
Diana Swolin-Eide, Gun Forsander, Auste Pundziute Lycka, Daniel Novak, Johannes Grillari, Andreas B. Diendorfer, Matthias Hackl, Per Magnusson
Summary: This case-control study aimed to investigate potential differences in circulating miRNAs between young individuals with long-duration type 1 diabetes (T1D) and healthy controls, as well as the expression of these identified miRNAs across different tissues. The results showed that 27 miRNAs were upregulated and one was downregulated in T1D. Six of these miRNAs were tissue-enriched. These findings have important implications for studying biomarkers for diabetes-related complications.
SCIENTIFIC REPORTS
(2023)
