Article
Ophthalmology
Tony Realini, Hazel Shillingford-Ricketts, Darra Burt, Goundappa K. Balasubramani
Summary: Afro-Caribbean patients with OAG at high risk for progression can achieve clinically and statistically significant reductions in IOP or medications through up to 24 months following a single 360 degrees SLT treatment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Susanna Friederike Koenig, Giovanni Montesano, Clarissa Ern Hui Fang, David Paul Crabb, Hari Jayaram, Jonathan Clarke
Summary: This study found that trabeculectomy can significantly reduce the rate of postoperative visual field loss progression (RoP), with a significant decrease in mean RoP after surgery.
Article
Multidisciplinary Sciences
Chun-Mei Hsueh, Jong-Shiuan Yeh, Jau-Der Ho
Summary: The purpose of this study was to identify risk factors for progression in treated normal-tension glaucoma (NTG) in highly myopic and non-highly myopic eyes. The results showed that the highly myopic group had a larger optic disc tilt ratio and thinner inferior macular thickness compared to the non-highly myopic group. Furthermore, basal pattern standard deviation and post treatment IOP were identified as risk factors for visual field progression in normal tension glaucoma patients.
Article
Biochemistry & Molecular Biology
Bartlomiej Bolek, Edward Wylegala, Dorota Tarnawska
Summary: This study found that in adult aniridia patients with glaucoma, Ahmed valve implantation was effective in reducing intraocular pressure and was well-tolerated. After 36 months of follow-up, the mean reduction in IOP was 40.2% and the qualified success rate was 85.7%. The most common complication was mild to moderate subconjunctival bleeding, and no other major or minor complications were observed.
Article
Ophthalmology
Shaza N. Al-Holou, Mandy O. M. Wong, Qiang (Ed) Zhang, James E. Sharpe, Alex Levin
Summary: This study aimed to report the clinical outcomes and risk factors for glaucoma in children and adolescents referred for increased cup:disk ratios (CDRs) to a tertiary referral center. A total of 167 patients were included, of whom 6 were found to have glaucoma. Diagnosis of glaucoma was apparent within the first three months of evaluation, and baseline intraocular pressure (IOP) and maximum IOP on diurnal curve were significantly associated with glaucoma diagnosis in these pediatric patients.
Article
Multidisciplinary Sciences
Ricardo Y. Abe, Heloisa A. Maestrini, Guilherme B. Guedes, Marcelo M. Nascimento, Camila I. Iguma, Herika Danielle de Miranda Santos, Muna Georges Nasr, Ricarte P. Lucena-Junior, Tiago S. Prata
Summary: Selective laser trabeculoplasty (SLT) in Brazil achieved relatively high success rates without sight-threatening complications. Factors such as denser angle pigmentation and corticosteroid treatment following SLT significantly influenced treatment success.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Alessandro A. Jammal, Samuel Berchuck, Eduardo B. Mariottoni, Angelo P. Tanna, Vital P. Costa, Felipe A. Medeiros
Summary: The study aimed to investigate the effect of systemic arterial blood pressure on the progressive structural damage in glaucoma. Results showed that lower mean arterial pressure and diastolic arterial pressure, adjusted for intraocular pressure, were significantly associated with faster rates of retinal nerve fiber layer loss, suggesting that systemic blood pressure may play a significant role in glaucoma progression.
Article
Multidisciplinary Sciences
Lei Guo, Jun Tao, Yang Tong, Shichao Chen, Xin Zhao, Rui Hua
Summary: This study investigated the morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The results showed significant differences in refractive error, intraocular pressure (IOP), and circumpapillary retinal nerve fibre layer (cpRNFL) thickness between the 3-week and 4-week groups. There were no significant differences in vascular characteristics between the two groups, but a positive correlation was found between total vessel length and cpRNFL thickness, and a negative correlation was found between total vessel length and IOP.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Mandy Oi Man Wong, Isabel S. W. Lai, Poemen Puiman Chan, Noel C. Y. Chan, Alison Y. Y. Chan, Gilda W. K. Lai, Vivian S. M. Chiu, Christopher Kai-Shun Leung
Summary: This study compared the intraocular pressure lowering effect and safety profile between pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) over a 12-month follow-up, and found no significant differences in terms of lowering intraocular pressure and safety between the two methods.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Chemistry, Medicinal
Xianbo Wu, Xinwei Yang, Qi Liang, Xiali Xue, Jianli Huang, Jie Wang, Yihua Xu, Rongsheng Tong, Maoyu Liu, Qiaodan Zhou, Jianyou Shi
Summary: Glaucoma is the third leading cause of blindness worldwide, with the number of patients projected to increase. High intraocular pressure is a major risk factor and cause of glaucoma, and drug therapy to lower intraocular pressure remains the first-line treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Qian Liu, Changgeng Liu, Haijun Li, Xiaoyuan Yang, Yangzeng Dong, Xiaomei Feng, Wenjun Cheng
Summary: This study retrospectively analyzed the characteristics, epidemiology, management, and outcomes of pediatric glaucoma in central China. The most common subtype was primary congenital glaucoma, and Trab and MAT were the commonly performed surgeries. Elevated intraocular pressure and eye pain were the most common signs and symptoms. Effective preventive measures and public education on glaucoma prevention, early diagnosis, and treatment are crucial.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Fabian A. Braeu, Thanadet Chuangsuwanich, Tin A. Tun, Shamira Perera, Rahat Husain, Alexandre H. Thiery, Tin Aung, George Barbastathis, Michael J. A. Girard
Summary: Using artificial intelligence techniques, the study aims to assess the robustness of the optic nerve head (ONH) by analyzing biomechanical knowledge through optical coherence tomography (OCT). Three AI algorithms were compared to predict ONH robustness and the DGCNN algorithm outperformed the others. The study suggests that ONH robustness can be assessed from a single OCT scan, providing potential insights into identifying fast visual field loss progressors.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Bruna Melchior, Carlos Gustavo De Moraes, Jayter S. Paula, George Cioffi, Christopher A. Girkin, Massimo A. Fazio, Robert Weinreb, Linda Zangwill, Jeffrey Liebmann
Summary: This study aimed to investigate whether adhering to current guidelines for intraocular pressure (IOP) target can slow the progression of glaucomatous visual field (VF). The results showed that adherence to treatment guidelines helped slow the rates of global VF progression at various stages of disease.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ilka Schmidt, Niklas Plange, Peter Walter, Antonis Koutsonas
Summary: This study investigates the use of implantable telemetric IOP sensors for glaucoma patients. The results show that these sensors demonstrate good long-term safety, tolerability, and functionality, allowing patients to self-measure their IOP.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Eunoo Bak, Yong Woo Kim, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Summary: The study found that progression of RNFL defect in POAG eyes is associated with an increase in angular extent of PPA. Disc haemorrhage, enlargement of PPA area, and angular extent were significantly associated with progression of RNFL defect.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Sanjeev Satyal, Jaesoon Kim, Soojin Kim, Ki Ho Park
Summary: Sovesudil showed significant IOP-lowering effects in NTG patients, with the 0.5% concentration meeting the criteria for superiority to the placebo. The most common adverse event was mild conjunctival hyperaemia.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Seoyoung Wy, Sooyeon Choe, Yun Jeong Lee, Eunoo Bak, Mirinae Jang, Seung Chan Lee, Ahnul Ha, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: This study aimed to develop and validate a decision tree model for predicting the mental health status of Korean caregivers of children with glaucoma. The results showed that evaluating the number of glaucoma surgeries and visual acuity in the better eye can help predict caregivers' mental illness.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Mirinae Jang, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Summary: Seasonal variation in optic disc hemorrhage (DH) was investigated through a retrospective observational study, revealing a higher incidence in winter and a significant association with temperature and intraocular pressure (IOP).
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ahnul Ha, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: This study aimed to investigate the relationship between optic disc morphological changes during myopia progression and the development of retinal nerve fiber layer defect (RNFLD). The results showed that progressive optic disc tilt during myopia progression was associated with a higher risk of RNFLD development in children with large vertical cup-to-disc ratio (vCDR).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yun Jeong Lee, Seung Chan Lee, Seo Young Wy, Hoo Young Lee, Hyang Lim Lee, Woo Hyung Lee, Byung-Mo Oh, Jin Wook Jeoung
Summary: This study compared ocular manifestations, visual field patterns, and visual field test performance in traumatic brain injury (TBI) and stroke patients. The results showed that strabismus and cataract were the most common ocular manifestations in TBI patients, whereas cataract and strabismus were the most common in stroke patients. Additionally, both groups had visual field defects and unreliable visual field test performance.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Ji Park, Jae-Hoon Jeong, Shin-Hyung Park
Summary: The root extract of Peucedanum praeruptorum Dunn (EPP) was found to have anticancer effects on non-small-cell lung cancer (NSCLC) cells by inhibiting cell growth, inducing apoptosis, and suppressing MET activity.
Article
Psychiatry
Jae Hoon Jeong, Sung-Wan Kim, Bong Ju Lee, Jung Jin Kim, Je-Chun Yu, Seung-Hee Won, Seung-Hwan Lee, Seung-Hyun Kim, Shi Hyun Kang, Euitae Kim, Young-Chul Chung, Kyu Young Lee
Summary: The study identified two factors related to psychosis symptom severity and cognition, which could help predict the clinical course of recent-onset psychosis patients.
PSYCHIATRY RESEARCH
(2022)
Article
Chemistry, Analytical
Joo Woo, So-Hyeon Jo, Gi-Sig Byun, Sun-Young Kim, Seok-Geun Jee, Ju-Hyeon Seong, Yeon-Man Jeong, Jae-Hoon Jeong
Summary: Location recognition and positioning systems are essential for unmanned vehicles. However, there are challenges in estimating location in GPS-denied environments, such as cumulative errors, hardware complexity, and precision positioning. This study proposes a lane positioning technique using chromaticity analysis of LED lights in tunnels and a fuzzy algorithm for accurate estimation.
Article
Ophthalmology
Sooyeon Choe, Ahnul Ha, Seulggie Choi, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: The purpose of this study was to determine the incidence of infantile cataract (IC) surgery and the risk of secondary glaucoma in the Korean population. A retrospective cohort study was conducted using the Korean National Health Claims database. The study found that the annual incidence of IC surgery ranged from 5.10 to 9.29 cases per 100,000 individuals, and the incidence rate of post-IC surgery glaucoma was 2.29 per 100 person-years. Factors such as intraocular lens implantation were found to reduce the risk of post-IC surgery glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jae-Hoon Jeong, Hyun-Ji Park, Shin-Hyung Park, Yung-Hyun Choi, Gyoo-Yong Chi
Summary: Chronic stress-induced catecholamines promote the migration and invasion of hepatocarcinoma and breast cancer cells through activation of the β2-AR and Src signaling pathway.
Article
Ophthalmology
Seung Hyeun Lee, Won Jun Lee, Kyoung Woo Kim, Jae Hoon Jeong, In Ki Park, Yeoun Sook Chun
Summary: Analyzing the efficacy and safety of 0.002% omidenepag Isopropyl (OMDI) eye drops in glaucoma patients, it was found that the drops significantly reduced intraocular pressure but also caused transient changes in refraction and corneal endothelial cells, an increase in central corneal thickness, and corneal erosion.
JOURNAL OF GLAUCOMA
(2023)
Article
Engineering, Electrical & Electronic
So-Hyeon Jo, Joo Woo, Sun Young Kim, Jae-Hoon Jeong
Summary: With the rise of electric vehicles, indoor driving robots, and wearable devices, the research on recognizing one's current location has been progressing. The reliance on GPS for self-localization in autonomous driving has led to the exploration of alternative technologies such as LiDAR, Wi-Fi, and visible light communication (VLC). This paper proposes a system that utilizes LED lights and different color temperature frequency components to estimate one's location in indoor spaces like tunnels. By collecting data using RGB sensors and analyzing color temperature and frequency components, the user's current location can be estimated with minimal errors, usually within a range of 0-2 cm. This technology is expected to generate valuable location data for indoor service robots and autonomous vehicles in areas where GPS signals are unavailable.
IEEE PHOTONICS JOURNAL
(2023)
Article
Ophthalmology
Sooyeon Choe, Young Kook Kim, Ki Ho Park, Hyuk Jin Choi, Jin Wook Jeoung
Summary: This study investigated the natural history of optic disc with physiologic large cup (PLC), as well as the risk factors for glaucoma conversion. The study identified higher VCDR, violation of the inferior superior nasal temporal neuroretinal rim thickness rule, presence of retinal arterial sclerosis, and lower total bilirubin level as factors associated with glaucoma development.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
Summary: This study assessed the performance of deep-learning models in predicting conversion to normal-tension glaucoma, and found that the models showed good predictive ability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)