Article
Medicine, General & Internal
Chunmiao Wang, Ruijin Ran, Xin Jin, Xiaohong Zhu
Summary: This study found that elevated concentrations of selenium in plasma and vitreous may be an important risk factor for diabetic retinopathy in patients with type 2 diabetes. Additionally, increased VEGF levels in the eyes may be closely related to intraocular selenium concentrations in patients with proliferative diabetic retinopathy.
Article
Endocrinology & Metabolism
Shengxin Liu, Ralf Kuja-Halkola, Henrik Larsson, Paul Lichtenstein, Jonas F. Ludvigsson, Ann-Marie Svensson, Soffia Gudbjornsdottir, Magnus Tideman, Eva Serlachius, Agnieszka Butwicka
Summary: The study found that children with childhood-onset type 1 diabetes and comorbid neurodevelopmental disorders, particularly ADHD and intellectual disability, are associated with poor glycemic control and a higher risk of diabetic complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Tetsuro Tsujimoto, Hiroshi Kajio
Summary: The study found that patients with type 2 diabetes who had good glycemic control during follow-up had a lower incidence of vision-threatening retinopathy; for patients with mild to moderate nonproliferative diabetic retinopathy, poor glycemic control significantly increased the incidence of vision-threatening retinopathy; patients with longer durations of diabetes had lower rates of remission of diabetic retinopathy.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Pharmacology & Pharmacy
Chaiwat Washirasaksiri, Weerachai Srivanichakorn, Nutsakol Borrisut, Tullaya Sitasuwan, Rungsima Tinmanee, Chayanis Kositamongkol, Pinyapat Ariyakunaphan, Chonticha Auesomwang, Naruemit Sayabovorn, Thanet Chaisathaphol, Pochamana Phisalprapa
Summary: The incidences of diabetes and diabetic retinopathy in high-risk individuals in Thailand increase significantly with higher degrees of dysglycemia. Individuals with FPG 110-125 mg/dl and HbA1c 6.0%-6.4% are more likely to develop type 2 diabetes and diabetic retinopathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Xinyuan Zhang, Yao Nie, Zhizhong Gong, Meidong Zhu, Bingjie Qiu, Qiyun Wang
Summary: ApoE, apoC-II/apoC-III, apoE/apoC-II, and apoB/non-HDL-C could be novel biomarkers for the occurrence and severity of DR, while apoA-I and apoA-II are protective factors for DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Jae Yong Park, Je Hyung Hwang, Min Ji Kang, Ha Eun Sim, Jae Suk Kim, Kyung Soo Ko
Summary: The study found that an increase in HbA1c standard deviation was associated with a higher risk of DR progression and that both mean HbA1c and HbA1c standard deviation were associated with a lower risk of progression. Achievable and consistent glycemic control may delay the progression of DR.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Niala den Braber, Miriam M. R. Vollenbroek-Hutten, Kathryn M. Westerik, Stephan J. L. Bakker, Gerjan Navis, Bert-Jan F. van Beijnum, Gozewijn D. Laverman
Summary: In insulin-treated patients with type 2 diabetes, high HbA(1c) did not decrease the occurrence of nocturnal hypoglycemia, and low HbA(1c) was not associated with the highest time in range (TIR). Optimal personalization of glycemic control requires the use of newer tools, including CGM-derived parameters.
Article
Endocrinology & Metabolism
Marilia B. Gomes, Fengming Tang, Hungta Chen, Javier Cid-Ruzafa, Peter Fenici, Kamlesh Khunti, Wolfgang Rathmann, Marina V. Shestakova, Filip Surmont, Hirotaka Watada, Jesus Medina, Iichiro Shimomura, Gabriela Luporini Saraiva, Andrew Cooper, Antonio Nicolucci
Summary: This study investigated the association between socioeconomic status and diabetes control in patients with type 2 diabetes, and found that socioeconomic factors are related to the quality of diabetes management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lorraine E. Levitt Katz, Neil H. White, Laure El Ghormli, Christine L. Chan, Kenneth C. Copeland, Terri H. Lipman, Marsha D. Marcus, Philip Zeitler
Summary: This study examined the development of diabetic peripheral neuropathy (DPN) in youth with type 2 diabetes and its relationship with glycemic control, sex, race/ethnicity, BMI, and other type 2 diabetes-associated factors.
Article
Medicine, Research & Experimental
Manuela Stoicescu, Horea Calniceanu, Ioan Tig, Sebastian Nemeth, Adriana Tent, Adelina Popa, Ciprian Brisc, Ioana Ignat-Romanul
Summary: The severity and extension of generalized chronic periodontitis was higher in type 2 diabetes mellitus patients with poor glucose control compared with those with good glucose control.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Nutrition & Dietetics
Wei-Lun Wen, Hui-Chun Huang, Hsiu-Chu Lin, Wan-Ching Lo, Szu-Chia Chen, Mei-Yueh Lee
Summary: In patients newly diagnosed with T2DM, glycemic durability is negatively associated with higher glycemic burden.
Article
Endocrinology & Metabolism
Wen-Cui Wan, Yang Long, Wei-Wei Wan, Hong-Zhuo Liu, Hao-Hao Zhang, Wei Zhu
Summary: The study found a decrease in plasma melatonin concentration in DR patients, making it a sensitive and specific marker for the diagnosis of DR. There was a significant positive relationship between total bilirubin and melatonin content. Further research is needed to understand the role of melatonin in DR.
WORLD JOURNAL OF DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Emin Grbic, Mojca Globocnik Petrovic, Ines Cilensek, Danijel Petrovic
Summary: The rs2048327 gene polymorphism is associated with diabetic retinopathy in patients with type 2 diabetes mellitus, suggesting its role as a genetic risk factor for this complication.
Article
Multidisciplinary Sciences
Donato Santovito, Lisa Toto, Velia De Nardis, Pamela Marcantonio, Rossella D'Aloisio, Alessandra Mastropasqua, Domenico De Cesare, Marco Bucci, Camilla Paganelli, Lucia Natarelli, Christian Weber, Agostino Consoli, Rodolfo Mastropasqua, Francesco Cipollone
Summary: DR patients have higher levels of circulating miR-25-3p and miR-320b, and lower levels of miR-495-3p, which are associated with disease severity. These miRNAs could serve as biomarkers for DR and suggest novel molecular targets for improving patient care.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Dongjun Dai, Yun Shen, Jingyi Lu, Yufei Wang, Wei Zhu, Yuqian Bao, Gang Hu, Jian Zhou
Summary: The study found that visit-to-visit variability of glycated albumin can predict the risk of incident diabetic retinopathy in patients with type 2 diabetes, and this predictive ability is independent of average HbA1c levels.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Ophthalmology
Claus Zehetner, Marion Moelgg, Emmanouil Bechrakis, Caroline Linhart, Nikolaos E. Bechrakis
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2018)
Article
Ophthalmology
Reinhard Angermann, Claus Zehetner, Patrick Sidoroff, Inga Waltl, Gerhard Kieselbach, Martina Kralinger
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2018)
Article
Ophthalmology
M. -S. Uckmann, M. Stattin, C. Zehetner, S. Neururer, L. Speicher
Editorial Material
Ophthalmology
R. Angermann, G. Haas, M. Hofer, M. Stattin, N. E. Bechrakis, C. Zehetner
Letter
Ophthalmology
Reinhard Angermann, Martin Stattin, Claus Zehetner
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Ophthalmology
Reinhard Angermann, Teresa Rauchegger, Yvonne Nowosielski, Marina Casazza, Angelika Bilgeri, Hanno Ulmer, Claus Zehetner
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Teresa Rauchegger, Reinhard Angermann, Anja Meusburger, Jana Schwab, Gertrud Haas, Martina Kralinger, Claus Zehetner
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Article
Ophthalmology
Reinhard Angermann, Nikolaos E. Bechrakis, Teresa Rauchegger, Marina Casazza, Yvonne Nowosielski, Claus Zehetner
JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Reinhard Angermann, Teresa Rauchegger, Yvonne Nowosielski, Christof Seifarth, Stefan Egger, Martina T. Kralinger, Gerhard F. Kieselbach, Claus Zehetner
Summary: In patients with nAMD, intravitreal aflibercept injections significantly upregulated Ang2 levels systemically while reducing VEGF-A levels. No significant effects were observed with ranibizumab injections.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Reinhard Angermann, Markus Hofer, Anna Lena Huber, Teresa Rauchegger, Yvonne Nowosielski, Marina Casazza, Valeria Falanga, Claus Zehetner
Summary: Patients with diabetic macular edema (DME) who do not adhere to intravitreal aflibercept therapy have worse visual outcomes compared to adherent patients, with a higher risk of developing proliferative diabetic retinopathy (DR).
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Yvonne Nowosielski, Benedikt Leitner, Teresa Rauchegger, Reinhard Angermann, Angeliki Psomiadi, Christoph Palme, Johannes Laimer, Michael Liebensteiner, Claus Zehetner
Summary: The study found that brake reaction times significantly improved in elderly drivers after undergoing bilateral cataract surgery, with a negative correlation between contrast sensitivity and reaction times. Therefore, preoperative evaluation of contrast sensitivity is crucial in cataract surgery decisions for elderly drivers.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Anna Lena Huber, Reinhard Angermann, Yvonne Nowosielski, Christof Seifarth, Martina T. Kralinger, Claus Zehetner
Summary: This study aimed to analyze the impact of intravitreal aflibercept injections on systemic levels of insulin-like growth factor-1 and vascular endothelial growth factor-A in patients with diabetic retinopathy and age-related macular degeneration. The results showed a significant increase in systemic insulin-like growth factor-1 levels one week after treatment, suggesting a potential role of insulin-like growth factor-1 in the pathomechanism of diabetic retinopathy.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Reinhard Angermann, Alexander Franchi, Victoria Stoeckl, Julia Rettenwander, Tanja Rettenwander, David Goldin, Martin Stattin, Martina T. Kralinger, Claus Zehetner
Summary: This study evaluated the visual and anatomical outcomes of patients with neovascular age-related macular degeneration (nAMD) who were nonpersistent to intravitreal aflibercept therapy. The results showed that the nonpersistent group had significantly worse visual acuity and a higher risk of developing fovea-involving fibrosis compared to the persistent group within 3 years.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Teresa Rauchegger, Georgios Blatsios, Gertrud Haas, Guenther Putz, Claus Zehetner
CASE REPORTS IN OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Inga Waltl, Claus Zehetner, Christof Seifarth, Florian Handle, Gerhard F. Kieselbach, Reinhard Angermann, Martina T. Kralinger
CURRENT EYE RESEARCH
(2018)