Article
Ophthalmology
Fabian A. Braeu, Thanadet Chuangsuwanich, Tin A. Tun, Shamira Perera, Rahat Husain, Alexandre H. Thiery, Tin Aung, George Barbastathis, Michael J. A. Girard
Summary: Using artificial intelligence techniques, the study aims to assess the robustness of the optic nerve head (ONH) by analyzing biomechanical knowledge through optical coherence tomography (OCT). Three AI algorithms were compared to predict ONH robustness and the DGCNN algorithm outperformed the others. The study suggests that ONH robustness can be assessed from a single OCT scan, providing potential insights into identifying fast visual field loss progressors.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Lei Guo, Jun Tao, Yang Tong, Shichao Chen, Xin Zhao, Rui Hua
Summary: This study investigated the morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The results showed significant differences in refractive error, intraocular pressure (IOP), and circumpapillary retinal nerve fibre layer (cpRNFL) thickness between the 3-week and 4-week groups. There were no significant differences in vascular characteristics between the two groups, but a positive correlation was found between total vessel length and cpRNFL thickness, and a negative correlation was found between total vessel length and IOP.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Golnoush Mahmoudinezhad, Mark Lin, Alessandro Rabiolo, Esteban Morales, Pradtana Hirunpatravong, Farideh Sharifipour, Joseph Caprioli
Summary: The presence of an acquired pit of the optic nerve in patients with primary open-angle glaucoma is associated with fast rates of visual field decay. Identifying patients with this condition may indicate a need for aggressive treatment to slow down the progression of their glaucoma.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ziyi Zhu, Susannah Waxman, Bo Wang, Jacob Wallace, Samantha E. Schmitt, Elizabeth Tyler-Kabara, Hiroshi Ishikawa, Joel S. Schuman, Matthew A. Smith, Gadi Wollstein, Ian A. Sigal
Summary: The study found that changes in IOP and ICP significantly deformed the scleral canal and lamina of the monkey ONH. There were individualized responses to pressure manipulation between eyes, and significant interactions between the effects of IOP and ICP on LC depth, BMO area, aspect ratio and planarity. Overall, elevating both pressures did not cancel out the effects in most eyes.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Ophthalmology
Ya Xing Wang, Songhomitra Panda-Jonas, Jost B. Jonas
Summary: The optic nerve head can be divided into the optic disc and the parapapillary region, with zones alpha, beta, gamma, and delta, which are associated with glaucoma and myopia. Myopic shift influences the shape and size of the optic disc, leading to changes in the lamina cribrosa and Bruch's membrane within highly myopic eyes.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Ophthalmology
Eun Jung Lee, Jong Chul Han, Changwon Kee
Summary: This study examined the morphology of the deep optic nerve head in tilted disc syndrome (TDS) and identified factors associated with retinal nerve fiber layer (RNFL) defects. The results showed that a higher baseline IOP, a larger tilt axis, a larger BMO-lamina cribrosa insertion angle, and more lamina cribrosa defects were associated with the presence of RNFL defects in TDS. These findings suggest a mechanism of RNFL defect associated with structural ONH deformation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Diana C. Lozano, Hari Jayaram, William O. Cepurna, Shandiz Tehrani, Lina Gao, Suzanne S. Fei, Dongseok Choi, Elaine C. Johnson, John C. Morrison
Summary: The purpose of this study was to clarify the gene expression responses in the optic nerve head (ONH) associated with single exposure to elevated intraocular pressure (IOP) in relation to chronic models of elevated IOP. The findings showed that the gene expression changed over time in the PT-CEI model, including upregulation of defense response, cell cycle, and immune response-related genes. These results contribute to a better understanding of optic nerve damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Eun Ji Lee, Ji Eun Song, Hye Seong Hwang, Jeong-Ah Kim, Seung Hyen Lee, Tae -Woo Kim
Summary: This study examined the parapapillary choroidal microvasculature dropout (CMvD) in glaucomatous eyes without beta-zone parapapillary atrophy (beta-PPA) and compared it with CMvD with beta-PPA. It was found that eyes with CMvD tended to have a worse visual field and patients with CMvD had lower diastolic blood pressure and more frequent cold extremities. These effects were independent of the presence of beta-PPA.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Computer Science, Information Systems
H. N. Veena, A. Muruganandham, T. Senthil Kumaran
Summary: Glaucoma is a leading retinal disease that can be automatically diagnosed using deep learning approaches. This paper introduces an efficient glaucoma master framework that utilizes convolutional neural networks to segment the optic cup and disc, achieving accurate diagnosis.
JOURNAL OF KING SAUD UNIVERSITY-COMPUTER AND INFORMATION SCIENCES
(2022)
Article
Ophthalmology
Mona Safizadeh, Amirreza Shaabani, Alireza Kamalipour, Masoud Aghsaei Fard, Kaileen Yeh, Mehdi Yaseri, Nikoo Hamzeh, Nassim Khatibi, Harsha Laxmana Rao, Robert Weinreb, Sasan Moghimi
Summary: OCTA can be used to detect reduced capillary density in fellow eyes of PXG patients, enabling earlier detection of glaucomatous loss in pseudoexfoliation disease and enhancing disease management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Health Care Sciences & Services
Wenqing Zhu, Xiangmei Kong, Ying Huang, Mingshui Fu, Xi Shen, Fang Wang, Xinghuai Sun
Summary: The study found that the diagnostic consistency between general ophthalmologists and glaucoma specialists in Shanghai was similar among outpatients, but general ophthalmologists tended to classify indefinite cases as POAG suspects, resulting in lower accuracy in diagnosing POAG. By focusing on the risk factors of POAG diagnosis, general ophthalmologists could improve the accuracy of their diagnoses.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Computer Science, Information Systems
Shailesh Kumar, Basant Kumar
Summary: This paper presents an early glaucoma detection algorithm using digital image processing techniques. The algorithm extracts early diagnostic parameters and uses a support vector machine model for classification, achieving efficient and accurate identification of early-stage glaucoma.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Review
Medicine, General & Internal
Bachar Kudsieh, Jose Ignacio Fernandez-Vigo, Ignacio Flores-Moreno, Jorge Ruiz-Medrano, Maria Garcia-Zamora, Muhsen Samaan, Jose Maria Ruiz-Moreno
Summary: Diagnosing glaucoma in highly myopic individuals based on optic nerve head (ONH) imaging is difficult due to the difficulty in distinguishing structural defects related to glaucoma from those related to myopia. Optical coherence tomography (OCT) has become a routine examination for glaucoma assessment, but its correct interpretation in highly myopic patients is still challenging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Thanadet Chuangsuwanich, Tin A. Tun, Fabian A. Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K. Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J. A. Girard
Summary: This study aimed to assess the strains in optic nerve head (ONH) induced by intraocular pressure (IOP) and gaze in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). The results showed that NTG subjects experienced higher strains due to gaze, while HTG subjects experienced higher strain due to IOP elevation, and these differences were most pronounced in the lamina cribrosa (LC) tissue.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Charumathi Sabanayagam, Rehena Sultana, Riswana Banu, Tyler Rim, Yih Chung Tham, Sunita Mohan, Miao Li Chee, Ya Xing Wang, Vinay Nangia, Kohta Fujiwara, E. Shyong Tai, Su Jeong Song, Mukharram M. Bikbov, Rajiv Raman, Ching Yu Cheng, Tien Yin Wong, Jost B. Jonas
Summary: This study found an inverse association between BMI and obesity with diabetic retinopathy in Asian adults with diabetes. Overweight did not show a significant association with diabetic retinopathy. Further longitudinal studies are needed to confirm these findings.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Zhe Pan, Chuan Chuan Wei, Xiaoyan Peng, Qi Zhang, Liang Xu, Hua Yang, Wen Bin Wei, Ya Xing Wang, Jost B. Jonas
Summary: The study found an enlargement of MRNFs during a 10-year follow-up, which was associated with higher serum concentration of low-density lipoproteins (LDL) and a more peripheral location of MRNFs. No new MRNFs were detected in the total study cohort during the same period.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Qing Zhang, Liang Xu, Liang Zhao, Rahul A. Jonas, Ya Xing Wang, Jost B. Jonas
Summary: The distribution and associations of the circumpapillary retinal nerve fibre layer thickness profile, characterized as peak height and peak position, in healthy eyes were investigated in this study. The peak RNFLT was thickest at Peak(IT), followed by Peak(ST) and Peak(SN), and was found to decrease with longer axial length, older age, female gender, and larger parapapillary gamma zone and beta zone width. The position of temporal peaks was influenced by gender, axial length, and BMO diameter.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Zhen Ling Teo, Yih-Chung Tham, Marco Yu, Miao Li Chee, Tyler Hyungtaek Rim, Ning Cheung, Mukharram M. Bikbov, Ya Xing Wang, Yating Tang, Yi Lu, Ian Y. Wong, Daniel Shu Wei Ting, Gavin Siew Wei Tan, Jost B. Jonas, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng
Summary: The translated paragraphs provide updated estimates on the global prevalence and number of people with diabetic retinopathy (DR) through 2045. The burden of DR is expected to increase disproportionately in countries in the Middle East and North Africa and the Western Pacific by 2045. Certain ethnic groups such as Hispanics and Middle Easterners with diabetes are more likely to have DR compared to Asians.
Article
Multidisciplinary Sciences
Huangjie Lu, Jian Xie, Xin-Yu Wang, Yaxing Wang, Zi-Jian Li, Kariem Diefenbach, Qing-Jiang Pan, Yuan Qian, Jian-Qiang Wang, Shuao Wang, Jian Lin
Summary: This study presents a dual-mode photochromic thorium-based metal-organic nanocluster for direct visible colorimetric dosimetry of UV, beta-ray, and gamma-ray radiation, allowing for quantification of ionizing radiations over a broad range. The material integrates dual-module photochromism and enables on-site detection of radiation dose changes through visible color transitions.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Rahul A. Jonas, Yan Ni Yan, Qi Zhang, Ya Xing Wang, Jost B. Jonas
Summary: Changes in disc-fovea distance (DFD) in highly myopic eyes over a 10-year period were associated with gamma zone enlargement, angle kappa reduction, and straightening of papillo-macular retinal vessels. The length of macular Bruch's membrane and the vertical distance between the temporal arterial arcade remained stable during follow-up. The findings suggest a temporal shift of Bruch's membrane and stretching of retinal nerve fibers in axially elongated eyes.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Li Dong, Xin Yue Hu, Yan Ni Yan, Qi Zhang, Nan Zhou, Lei Shao, Ya Xing Wang, Jie Xu, Yin Jun Lan, Yang Li, Jian Hao Xiong, Cong Xin Liu, Zong Yuan Ge, Jost B. Jonas, Wen Bin Wei
Summary: This study developed a deep-learning-based algorithm to estimate axial length and SFCT using conventional color fundus images with good performance and small absolute errors. The algorithm has the potential to be helpful in the semi-automatic assessment of the eye.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Nan Zhou, Xiaolin Xu, Yueming Liu, Yaxing Wang, Wenbin Wei
Summary: The modified intravitreal injection regimen of MTX is effective in inducing clinical remission of intraocular involvement in PCNSL patients with few complications. Further studies are needed to determine if this approach extends life expectancy.
Article
Cell Biology
Jingfei Hu, Hua Wang, Zhaohui Cao, Guang Wu, Jost B. Jonas, Ya Xing Wang, Jicong Zhang
Summary: In this study, a VC-Net model is proposed to enhance the accuracy and precision of A/V classification by combining vessel distribution and edge information. The experimental results show competitive performance of the model in A/V classification and vessel segmentation tasks. Additionally, the model demonstrates good robustness when tested with fusion datasets of different scales.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Jost B. Jonas, Yan Ni Yan, Qi Zhang, Qing Zhang, Wen Bin Wei, Rahul A. Jonas, Ya Xing Wang
Summary: This study aimed to explore explanatory parameters related to the decrease in retinal nerve fiber layer (RNFL) thickness. The results showed that the decrease in RNFL thickness is associated with the size of the parapapillary gamma zone and the elongation of the disc-fovea distance.
ACTA OPHTHALMOLOGICA
(2022)
Article
Optics
Hui Xie, Zhe Pan, Leixin Zhou, Fahim Zaman, Danny Chen, Jost Jonas, Weiyu Xu, Ya Wang, Xiaodong Wu
Summary: Segmentation of multiple surfaces in optical coherence tomography (OCT) images is a challenging problem. This study proposes a method that combines deep learning and graph models to simultaneously detect multiple optimal surfaces by learning parameterized surface cost functions. The optimization problem is solved by the primal-dual interior-point method.
Article
Ophthalmology
Jing-Yan Yang, Wen-Jia Zhou, Qian Wang, Yang Li, Yan-Ni Yan, Ya-Xing Wang, Shou-Ling Wu, Wen-Bin Wei
Summary: This study evaluated the retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal mine workers. The results showed that the retinal nerve fiber layer was thicker and the retinal vessels were larger in coal miners compared to the control group. These findings suggest that the underground working environment in coal mines may lead to retinal vessel dilation and inflammation.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Wenjia Zhou, Jingyan Yang, Qian Wang, Yaxing Wang, Yanni Yan, Shouling Wu, Shuohua Chen, Wenbin Wei
Summary: The study aimed to investigate the impact of systemic stressors, such as fasting plasma glucose (FPG), on the retinal microvasculature in individuals without diabetes. The results showed a negative correlation between deep capillary plexus (DCP) density and FPG concentration, suggesting that hyperglycemia may lead to early retinal capillary alterations in individuals without diabetes. Routine optical coherence tomographic angiography (OCTA) could be beneficial for screening subclinical microvasculature and monitoring individuals at high risk of atherosclerotic cardiovascular disease (ASCVD).
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Rahul A. Jonas, Camilla F. Brandt, Qi Zhang, Ya X. Wang, Jost B. Jonas
Summary: The study found that an inferior fovea location is associated with a wider inferior gamma zone, suggesting a downward shifting of Bruch's membrane as the cause for a wider inferior gamma zone.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medical Informatics
Yih-Chung Tham, Ayesha Anees, Liang Zhang, Jocelyn Hui Lin Goh, Tyler Hyungtaek Rim, Simon Nusinovici, Haslina Hamzah, Miao-Li Chee, Gabriel Tjio, Shaohua Li, Xinxing Xu, Rick Goh, Fangyao Tang, Carol Yim-Lui Cheung, Ya Xing Wang, Vinay Nangia, Jost B. Jonas, Bamini Gopinath, Paul Mitchell, Rahat Husain, Ecosse Lamoureux, Charumathi Sabanayagam, Jie Jin Wang, Tin Aung, Yong Liu, Tien Yin Wong, Ching-Yu Cheng
Summary: This study developed a deep learning algorithm for detecting visually impairments related to eye diseases, showing good performance with high sensitivity and specificity. The algorithm, based on retinal photographs, successfully identifies disease-related visual impairments and can provide more timely and accurate referrals in the clinical pathway.
LANCET DIGITAL HEALTH
(2021)
