Journal
ACTA OPHTHALMOLOGICA
Volume 90, Issue 7, Pages 683-685Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1755-3768.2011.02125.x
Keywords
Alzheimer disease; case register; dementia; epidemiology; glaucoma; neurodegeneration; normal tension glaucoma; register; retrospective
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Purpose: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD). Methods: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia]. Results: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMRdementia was 0.20 (95% CI 0.011.11). No patient developed AD. Conclusion: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.
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