Epinephrine, norepinephrine, and isoproterenol dose-outflow facility response relationships in cynomolgus monkey eyes with and without ciliary muscle retrodisplacement

Summary: Intraocular pressure (IOP) is influenced by trabecular outflow pathways. Eye cannulation is the standard method for measuring outflow resistance but is invasive. A new technology using a smart portable micropump allows for autonomous measurement of outflow facility in conscious rats. The micropump can adjust flow rate to maintain IOP at a target level. The device offers a unique tool for long-term monitoring of ocular health.

Summary: This study investigates the differences in outflow facility between high-flow and low-flow segments of the conventional outflow pathway in porcine eyes. It finds that there is an uneven distribution of local outflow facility across different parts of the trabecular meshwork.

Summary: This study aimed to investigate the accommodative movements of the choroid in the optic nerve region in humans and their relationship with changes in lens dimensions due to aging. The results showed that the choroidal thickness decreased significantly with age in the unaccommodated state, and it was negatively correlated with the lens thickness in both the unaccommodated and accommodated states. During accommodation, the choroid showed significant movements, thinning and moving outward from the optic nerve head. These movements were not affected by age or accommodative amplitude.

Summary: This study investigated the glycocalyx morphology in the trabecular outflow pathway of monkey eyes with experimental glaucoma. The results showed decreased outflow facility in laser-treated eyes and significant changes in the glycocalyx coverage and thickness in different regions.