Article
Multidisciplinary Sciences
Poramaet Laowanapiban, Kanchalika Sathianvichitr, Niphon Chirapapaisan
Summary: The clinical distinction between suprasellar compressive optic neuropathy (CON) and open-angle glaucomatous optic neuropathy (GON) can be challenging, but specific thinning parameters of the retina can help differentiate their characteristics.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Brennan D. D. Eadie, Oksana M. M. Dyachok, Jack H. H. Quach, Charles E. E. Maxner, Paul E. E. Rafuse, Lesya M. M. Shuba, Jayme R. R. Vianna, Balwantray C. C. Chauhan, Marcelo T. T. Nicolela
Summary: By comparing OCT parameters of patients with NAION and GON, we found that MRW is a clinically useful index for differentiating these two optic neuropathies.
Article
Ophthalmology
Eren Ekici, Sasan Moghimi, Huiyuan Hou, James Proudfoot, Linda M. Zangwill, Jiun L. Do, Won Hyuk Oh, Alireza Kamalipour, Jeffrey M. Liebmann, Carlos Gustavo De Moraes, Christopher A. Girkin, Nevin El-Nimri, Robert N. Weinreb
Summary: The severity and prevalence of central visual field loss varied among different glaucomatous optic disc phenotypes. Glaucomatous eyes with focal ischemic (FI) and myopic glaucoma (MY) optic disc phenotypes are more likely to have 10-2 visual field loss.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Physiology
Ze-yang Yu, Ying-qi Xing, Cong Li, Si-bo Wang, Xiao-nan Song, Cui-cui Wang, Li-juan Wang
Summary: This study aimed to evaluate the reliability of ultrasonic optic disc height (ODH) and optic nerve sheath diameter (ONSD) for elevated intracranial pressure (ICP). The results showed a positive correlation between ODH and ICP. Combining ODH and ONSD provided a more accurate assessment of ICP.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Ophthalmology
Saerom Youn, Brandon Loshusan, James J. Armstrong, J. Alexander Fraser, Steffen Hamann, Lulu L. C. D. Bursztyn
Summary: The study aimed to identify the most accurate diagnostic imaging modality for detecting optic disc drusen (ODD), comparing B-scan ultrasonography (US), fundus photography, fundus autofluorescence (FAF), and enhanced depth imaging optical coherence tomography (EDI-OCT). Among all modalities, EDI-OCT demonstrated the highest sensitivity, accuracy, and examiner confidence in detecting ODD, making it the preferred initial diagnostic modality.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Emma K. Geiduschek, Colleen M. Mcdowell
Summary: Glaucoma is a progressive disease that leads to irreversible blindness. Understanding the cellular mechanisms behind optic nerve head damage during disease progression can help identify new drug targets and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Christopher Kai Shun Leung, Alexander Ka Ngai Lam, Robert Neal Weinreb, David F. Garway-Heath, Marco Yu, Philip Yawen Guo, Vivian Sheung Man Chiu, Kelvin Ho Nam Wan, Mandy Wong, Ken Zhongheng Wu, Carol Yim Lui Cheung, Chen Lin, Carmen Kar Mun Chan, Noel Ching Yan Chan, Ka Wai Kam, Gilda Wing Ki Lai
Summary: Optical texture analysis of the retinal nerve fibre layer, through an algorithm integrating thickness and reflectance measurements from standard wide-field optical coherence tomography, outperforms conventional tomographic analysis in the detection of optic neuropathies.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Cell Biology
Ying Zhu, Rui Wang, Anthony C. Pappas, Philip Seifert, Andrej Savol, Ruslan I. Sadreyev, Daniel Sun, Tatjana C. Jakobs
Summary: The optic nerve head is believed to be the initial site of retinal ganglion cell injury in glaucoma. Astrocytes in the optic nerve head respond to injury by undergoing characteristic changes in cell morphology and gene expression profile. Increased intraocular pressure leads to upregulation of astrocytic phagocytosis, indicating its involvement in the early stages of glaucoma.
Article
Multidisciplinary Sciences
Philipp Lorenz-Spreen, Michael Geers, Thorsten Pachur, Ralph Hertwig, Stephan Lewandowsky, Stefan M. Herzog
Summary: Online platforms provide advertisers with the ability to target recipients' personal vulnerabilities by tailoring different messages for the same thing. A simple intervention prompting participants to reflect on their own personality traits can boost their ability to accurately identify targeted ads, showing potential for increasing user autonomy and transparency on platforms.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Karim Kandil, Fahmi Zairi, Fahed Zairi
Summary: There is a growing demand to develop predictive medicine through the creation of predictive models and digital twins of different body organs. This article presents a numerical model to estimate the long-term aging effect on the human intervertebral disc response using a microstructure-based mechanistic approach. It reveals important insights about the relationship between age-dependent microstructure features, disc mechanics, and disc damage.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Flora Gouzerh, Guila Ganem, Anais Pichevin, Laurent Dormont, Frederic Thomas
Summary: The olfactory capacity of animals has been utilized by humans for various activities, including detecting cancer using scent. This paper reviews recent studies on using animals, such as dogs, rodents, insects, and nematodes, to detect tumor scents, with a success rate close to 90%. The paper discusses the methodologies, animal models, and medical perspectives for cancer diagnosis using odors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Ophthalmology
Yi Pang, Kelly A. Frantz, Huizi Kelly Yin
Summary: The purpose of this study was to evaluate the effectiveness of Cirrus spectral domain optical coherence tomography (SD-OCT) in diagnosing congenital optic nerve hypoplasia (CONH) compared to the disc-macula distance to disc diameter (DM:DD) ratio. The study found that the DM:DD ratio was superior to OCT in diagnosing CONH with a higher sensitivity and specificity. However, the ratio is subject to inter-examiner variability and can be challenging to obtain. The study concluded that Cirrus SD-OCT is a valid objective test for diagnosing CONH, but caution is advised when using it in segmental CONH or in cases with no light perception (NLP). The optimal cut-off value for Cirrus SD-OCT disc area to differentiate a hypoplastic from a normal optic disc was suggested to be 1.66 mm2.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Medicine, General & Internal
An Ran Ran, Xi Wang, Poemen P. Chan, Noel C. Chan, Wilson Yip, Alvin L. Young, Mandy O. M. Wong, Hon-Wah Yung, Robert T. Chang, Suria S. Mannil, Yih Chung Tham, Ching-Yu Cheng, Hao Chen, Fei Li, Xiulan Zhang, Pheng-Ann Heng, Clement C. Tham, Carol Y. Cheung
Summary: The study aims to develop a multi-task 3D DL model to detect GON and MF simultaneously from SDOCT scans. The proposed model showed higher accuracy in internal validation compared to average RNFL thickness, with comparable performance in external testing. Presence of MF did not affect the accuracy of GON detection in general, but the multi-task DL model performed significantly better in patients without MF in one external testing dataset.
FRONTIERS IN MEDICINE
(2022)
Article
Computer Science, Information Systems
H. N. Veena, A. Muruganandham, T. Senthil Kumaran
Summary: Glaucoma is a leading retinal disease that can be automatically diagnosed using deep learning approaches. This paper introduces an efficient glaucoma master framework that utilizes convolutional neural networks to segment the optic cup and disc, achieving accurate diagnosis.
JOURNAL OF KING SAUD UNIVERSITY-COMPUTER AND INFORMATION SCIENCES
(2022)
Review
Clinical Neurology
Laura Donaldson, Edward Margolin
Summary: For patients with swollen optic nerve head and normal visual function, optic disc drusen (ODD) should be the first consideration, followed by further investigations to rule out other possible causes. Patients with imaging signs of raised intracranial pressure should undergo lumbar puncture to assess for intracranial hypertension, with prompt ophthalmological consultation if necessary.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
