Article
Nutrition & Dietetics
Natassia Rodrigo, Deborah Randall, Farah Abu Al-Hial, Kathleen L. M. Pak, Alexander Junmo Kim, Sarah J. Glastras
Summary: This study evaluated the association between glucose levels on the 75g oral glucose tolerance test (OGTT) and treatment and outcomes of gestational diabetes mellitus (GDM). The results showed that fasting hyperglycemia, either alone or in combination with elevated post-glucose levels, was associated with the need for pharmacotherapy. Women with higher BMI were more likely to have fasting hyperglycemia. There was an increased risk of early term birth in women with mixed fasting and post-glucose hyperglycemia.
Review
Medicine, General & Internal
Mengdie Liu, Minhui Liu, Shuo Wang, Yumei Sun, Fang Zhou, Hongyu Sun
Summary: Napping is associated with increased diabetes risk and poor glycaemic control. Habitual napping is related to increased diabetes risk and poor glycaemic control in patients with diabetes, while napping durations less than 30 minutes are not associated with diabetes.
Article
Cell Biology
Lucia Scisciola, Maria R. Rizzo, Raffaele Marfella, Vittoria Cataldo, Rosaria A. Fontanella, Eugenio Boccalone, Giuseppe Paolisso, Michelangela Barbieri
Summary: Conflicting data exist on the relationship between hyperglycaemia, diabetes, and SIRT6 expression. This study found that high glucose exposure led to lower DNA methylation in the SIRT6 promoter, increased expression of SIRT6 and TET2, and persisting epigenetic changes after glucose normalization. Diabetic patients had lower SIRT6 DNA methylation levels that correlated inversely with plasma glucose levels, indicating the involvement of epigenetic mechanisms in regulating SIRT6 expression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Rudolf Dupak, Jana Hrnkova, Nikoleta Simonova, Jan Kovac, Eva Ivanisova, Anna Kalafova, Monika Schneidgenova, Marta Soltesova Prnova, Jan Brindza, Katarina Tokarova, Marcela Capcarova
Summary: Sea buckthorn, known for its antioxidant effects, can effectively suppress hyperglycemia, reduce water intake, and lower sorbitol levels in the lens of the eyes in diabetic rats.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Immunology
Phillip Ssekamatte, Marjorie Nakibuule, Rose Nabatanzi, Moses Egesa, Carol Musubika, Mudarshiru Bbuye, Matthew R. Hepworth, Derek G. Doherty, Stephen Cose, Irene Andia Biraro
Summary: The study showed that patients with LTBI and T2DM, as well as T2DM patients, had slight alterations in ILC immune responses, and poor T2DM control also slightly changed these immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Shrey Dwivedi, Princy Choudhary, Ayushi Gupta, Sangeeta Singh
Summary: Mucormycosis is an opportunistic fungal disease that poses a threat to immunocompromised COVID-19 patients. Corticosteroidal therapy may worsen the condition and increase the risk of mucormycosis infection.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yanlang He, Zhijie Huang, Changli Wei, Jianyong Chen
Summary: Hypertriglyceridemia-induced acute pancreatitis rarely occurs in the second trimester of pregnancy with gestational diabetes mellitus. This case report presents a case of abruptio placentae and epileptic seizure in a woman with gestational diabetes mellitus and hypertriglyceridemia-induced acute pancreatitis, suggesting that the occurrence of epileptic seizure may be associated with concomitant hyperglycemia and can be terminated with insulin treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rik Mencke, Amarens van der Vaart, Andreas Pasch, Geert Harms, Femke Waanders, Henk J. G. Bilo, Harry van Goor, Jan-Luuk Hillebrands, Peter R. van Dijk
Summary: The study found that in patients with type 2 diabetes, serum T-50 values were closely related to factors such as gender, smoking, blood sugar control, blood pressure, insulin use, and diabetes history, but not related to cardiovascular event history or microvascular disease. This indicates that serum calcification propensity is independently associated with glycemic control in diabetic patients, suggesting that lower HbA1c levels may be associated with better cardiovascular outcomes. Prospective studies are needed to further investigate the relationship between T-50 and a history of macrovascular events.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Nutrition & Dietetics
Zaleha Md Isa, Norizzati Amsah, Norfazilah Ahmad
Summary: Vitamin D deficiency and insufficiency have negative effects on the outcome of Type 2 Diabetes Mellitus patients, including glycaemic control and the development of complications. Thus, screening for vitamin D levels in T2DM patients may be beneficial.
Article
Endocrinology & Metabolism
Celien Tigchelaar, Mark L. van Zuylen, Abraham H. Hulst, Benedikt Preckel, Andre P. van Beek, Ido P. Kema, Jeroen Hermanides, Anthony R. Absalom
Summary: This study finds that hyperglycemia leads to an increase in polyol concentrations in the cerebrospinal fluid of patients without major neurological disease. Additionally, it provides the first indication of upregulation of the cerebral polyol pathway in patients with diabetes without evident neurological abnormalities.
Review
Dentistry, Oral Surgery & Medicine
Rafaella Milla Nunes Pimenta, Alexandre Henrique dos Reis-Prado, Sabrina de Castro Oliveira, Juliana Goto, Leopoldo Cosme-Silva, Luciano Tavares Angelo Cintra, Francine Benetti
Summary: This systematic review evaluated the influence of diabetes mellitus (DM) on the response of the pulp tissue and in the pulp cells behaviour. The results indicated that DM may increase inflammation/degeneration and mineralization in the pulp tissue while reducing cell proliferation. Further analyses in human pulp are important to provide stronger evidence.
Article
Endocrinology & Metabolism
Alon Haim, Rotem Shalev Shamy, Dana Ridel, Yisrael Parmet, Neta Loewenthal, Idit Liberty, Shai Tejman-Yarden, Eli Hershkovitz, Avinoam Borowsky
Summary: This study shows that acute hyperglycemia impairs driving performance in young type 1 diabetes patients by reducing hazard perception, decreasing the number of glances, shortening headway distance, and increasing the number of braking events.
DIABETES & METABOLISM
(2021)
Review
Neurosciences
Klara Komici, Grazia Daniela Femminella, Leonardo Bencivenga, Giuseppe Rengo, Gennaro Pagano
Summary: Studies show that while the prevalence of DM in PD patients is similar to the general population, individuals with DM have a higher risk of developing PD. Furthermore, the presence of DM is associated with greater severity and faster progression of PD symptoms compared to PD patients without DM.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Endocrinology & Metabolism
Juergen G. Okun, Patricia M. Rusu, Andrea Y. Chan, Yuqin Wu, Yann W. Yap, Thomas Sharkie, Jonas Schumacher, Kathrin V. Schmidt, Katherine M. Roberts-Thomson, Ryan D. Russell, Annika Zota, Susanne Hille, Andreas Jungmann, Ludovico Maggi, Young Lee, Matthias Bluher, Stephan Herzig, Michelle A. Keske, Mathias Heikenwalder, Oliver J. Mueller, Adam J. Rose
Summary: Elevated hepatic alanine catabolism promotes hyperglycaemia and reduces skeletal muscle protein synthesis, linking sarcopenia with hyperglycaemia in type 2 diabetes. Obesity and sarcopenia are often associated in aging and may together contribute to the progression of conditions such as diabetes and frailty. Liver alanine metabolism driven by chronic glucocorticoid and glucagon signaling promotes hyperglycaemia and skeletal muscle wasting, revealing a metabolic inter-tissue cross-talk in type 2 diabetes.
Article
Endocrinology & Metabolism
C. C. van Olden, M. Muilwijk, K. Stronks, B. J. van den Born, E. P. Moll van Charante, M. Nicolau, A. H. Zwinderma, M. Nieuwdorp, A. K. Groen, I. G. M. van Valkengoed
Summary: The prevalence of intermediate hyperglycaemia (IH) is higher among ethnic minority groups compared to the Dutch majority. However, there is no significant difference in the association of IH classifications with the incidence of T2DM between ethnic groups.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Editorial Material
Ophthalmology
Alejandro Cervino, Jose F. Alfonso, Hema Radhakrishnan, Jose M. Gonzalez-Meijome, Rune Brautaset
JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Engineering, Biomedical
Robert Montes-Mico, Alejandro Cervino, Noelia Martinez-Albert, Jose Garcia-Marques, Sarah Marie
EXPERT REVIEW OF MEDICAL DEVICES
(2020)
Review
Ophthalmology
Cristian Talens-Estarelles, Jose Vicente Garcia-Marques, Alejandro Cervino, Santiago Garcia-Lazaro
Summary: The use of digital displays is linked to an increase in dry eye symptoms, including abnormal blinking, incomplete eyelid closure, increased palpebral fissure, and meibomian gland dysfunction, leading to reductions in tear volume and stability, and significant ocular surface damage.
Article
Ophthalmology
Jose Vicente Garcia-Marques, Rute Macedo-de-Araujo, Daniela Lopes-Ferreira, Alejandro Cervino, Santiago Garcia-Lazaro, Jose Manuel Gonzalez-Meijome
Summary: The study found that the dual-focus contact lens design compared to the monofocal lens resulted in a slight reduction in short-term pre-lens tear film stability, potentially affecting visual performance and comfort during dual-focus contact lens wear.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2022)
Article
Ophthalmology
Jose Vicente Garcia-Marques, Cristian Talens-Estarelles, Noelia Martinez-Albert, Santiago Garcia-Lazaro, Alejandro Cervino
Summary: The study demonstrates that tear film-dynamic metrics are emerging parameters for indirectly evaluating tear film quality in natural conditions with acceptable repeatability.
CURRENT EYE RESEARCH
(2021)
Article
Ophthalmology
Jose Vicente Garcia-Marques, Cristian Talens-Estarelles, Santiago Garcia-Lazaro, Alejandro Cervino
Summary: This study developed and validated new metrics to objectively assess the lipid layer thickness (LLT) through the analysis of grey intensity values obtained from videokeratography. The new metrics showed high performance in correlation with LLT, sensitivity, specificity, and accuracy, and could be used as an easy, repeatable, objective, and accessible method to improve the detection and monitoring of dry eye disease and meibomian gland dysfunction.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Roberto Zaldivar, Roger Zaldivar, Pablo Adamek, Alejandro Cervino
Summary: This study assessed the use of intraoperative OCT to detect and adjust high vault during ICL implantation surgery. The results showed that intraoperative vault adjustment using OCT was effective in significantly changing the vault value, and it was correlated with white-to-white distance and pre-rotation vault. The postoperative vault values decreased gradually over time.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2022)
Article
Ophthalmology
Cristian Talens-Estarelles, Jose Vicente Garcia-Marques, Alejandro Cervino, Santiago Garcia-Lazaro
Summary: The study aimed to identify the impact of computer use on dry eye and its association with ocular parameters. The results showed that individuals with more severe dry eye symptoms were more likely to experience an increase in symptoms during computer use, while those with poorer tear stability were more likely to experience a reduction in tear stability.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Ophthalmology
Carlos Palomino-Bautista, Alejandro Cervino, Ricardo Cuina-Sardina, David Carmona-Gonzalez, Alfredo Castillo-Gomez, Ruben Sanchez-Jean
Summary: This study aimed to assess the depth of field in patients after cataract surgery and bilateral implantation of a trifocal intraocular lens. The results showed that the trifocal lens significantly improved visual acuity at different distances and provided wide depth of field values. The patient satisfaction rates were also high.
Article
Ophthalmology
Jose Vicente Garcia-Marques, Rute Juliana Macedo-De-Araujo, Colm McAlinden, Miguel Faria-Ribeiro, Alejandro Cervino, Jose Manuel Gonzalez-Meijome
Summary: This study assessed and compared the short-term visual and optical quality and tear film stability of two dual-focus prototype myopia control contact lenses with different inner zone diameters. The results showed that both lenses provided acceptable visual performance under photopic conditions. The lens with a 4.0 mm inner zone diameter had better contrast sensitivity at high frequencies and lower light disturbance.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Biology
Jose Vicente Garcia-Marques, Cristian Talens-Estarelles, Santiago Garcia-Lazaro, Alejandro Cervino
Summary: This study aims to evaluate the effects of soft contact lens wear and its duration on tear film and meibomian gland. The results showed that contact lens wearers had higher meibomian gland dropout and lower gland visibility. Prolonged contact lens wear was associated with increased dry eye symptoms and entropy of the meibomian glands.
Editorial Material
Biology
Jose-Maria Sanchez-Gonzalez, Carlos Rocha-de-Lossada, Alejandro Cervino
Review
Ophthalmology
Juan A. Sanchis-Gimeno, Nabeela Hasrod, Ana M. Calvo-Maroto, Shahed Nalla, Alejandro Cervino
Summary: The aim of this study was to determine the impact of diabetes mellitus (DM) on central corneal thickness (CCT) and its correlation with diabetes duration and glycated haemoglobin (HbA1c) levels. The study found that DM patients usually have increased CCT values, although there is no unanimity regarding the effect of DM duration and increased HbA1c levels on CCT values.
AFRICAN VISION AND EYE HEALTH JOURNAL
(2022)
Review
Ophthalmology
Ana M. Calvo-Maroto, Alejandro Cervino
CLINICAL OPTOMETRY
(2018)
Article
Ophthalmology
Daniel Monsalvez-Romin, Alberto Dominguez-Vicent, Santiago Garcia-Lazaro, Jose J. Esteve-Taboada, Alejandro Cervino
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2018)