Article
Medicine, General & Internal
Christoph Tappeiner, Han Sol Bae, Kai Rothaus, Karoline Walscheid, Arnd Heiligenhaus
Summary: The study aimed to analyze the occurrence and risk factors for macular edema (ME) in patients with juvenile idiopathic arthritis-associated uveitis (JIA-U). The results indicated that older age, worse eye conditions, and higher laser-flare photometry values were independent risk factors for ME manifestation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jinsoo Kim, Min Seon Park, Soonil Kwon, Kwang Nam Kim, Han Wool Kim, Bum-Joo Cho
Summary: This study aimed to investigate the clinical features and risk factors of uveitis in Korean children with juvenile idiopathic arthritis (JIA). The JIA-associated uveitis (JIA-U) developed in 9.8% of JIA patients. The study found that the uveitis group had a higher prevalence of the oligoarthritis-persistent subtype and knee joint involvement, suggesting their association with JIA-U.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Pediatrics
Mikhail M. Kostik, Ekaterina V. Gaidar, Lubov S. Sorokina, Ilya S. Avrusin, Tatiana N. Nikitina, Eugenia A. Isupova, Irina A. Chikova, Yuri Yu. Korin, Elizaveta D. Orlova, Ludmila S. Snegireva, Vera V. Masalova, Margarita F. Dubko, Olga V. Kalashnikova, Vyacheslav G. Chasnyk
Summary: The presence of uveitis is a risk factor for JIA flare, while methotrexate can reduce the cumulative flare probability.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Marta Gruca, Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Agnieszka Wosiak, Aleksandra Stasiak, Karolina Sikorska, Jerzy Stanczyk, Elzbieta Smolewska
Summary: The aim of this study was to assess CVD risk factors in patients with JIA. IMT, metabolic parameters and health behaviors were evaluated. The study found that CVD risk factors were present in both groups, with more JIA patients having abnormal BMI compared to the control group. Dietary habits were not associated with IMT or other parameters in the JIA group. Only one JIA patient met the criteria for ideal cardiovascular health. The pursuit of ideal cardiovascular health should be given attention in the pediatric population, especially in patients with chronic diseases like JIA. Further studies are needed to apply carotid artery IMT measurement in assessing CVD risk.
Article
Ophthalmology
Roos A. W. Wennink, Viera Kalinina Ayuso, Els M. Pameijer, Coco C. Dekkers, Irem Bozkir, Joke H. de Boer
Summary: This study aimed to compare the development of ocular complications and visual prognosis in juvenile idiopathic arthritis associated uveitis (JIA-uveitis) with the previous decade. The results showed that the prognosis of JIA-uveitis has improved over the past decade, with a reduction in the number of cataract surgeries and secondary glaucoma, and a decreased risk of vision loss for patients.
ACTA OPHTHALMOLOGICA
(2022)
Review
Medicine, General & Internal
Pierre Quartier
Summary: Children with early onset juvenile idiopathic arthritis, especially with positive antinuclear antibodies, may develop chronic anterior uveitis, which requires regular slit lamp examination and prompt treatment. Therapy options range from local steroid treatment to systemic immunomodulatory therapy, tailored to individual patient needs, with involvement of expert ophthalmologists and pediatricians. Treatment should not be easily interrupted and may need to be intensified in certain cases for optimal disease control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Achille Marino, Luca Marelli, Paolo Nucci, Roberto Caporali, Elisabetta Miserocchi
Summary: This study aimed to evaluate the efficacy and safety of subcutaneous tocilizumab in JIA patients with refractory uveitis. The results showed that SC-TCZ significantly reduced the rate of uveitis flare and achieved complete treatment response in some patients. Moreover, SC-TCZ was well-tolerated without any observed side effects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Justine R. Smith, Janet M. Matthews, Diana Conrad, Anthony J. Hall, Rachael L. Niederer, Davinder Singh-Grewal, Mei-Ling Tay-Kearney, Jane M. Wells, Sophia L. Zagora, Peter J. McCluskey
Summary: The Australian and New Zealand-based uveitis-specialized ophthalmologists have developed 18 consensus statements for managing chronic anterior uveitis in children with JIA, providing regionally applicable advice for ophthalmic care.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Elena Bolletta, Marco Coassin, Danilo Iannetta, Valentina Mastrofilippo, Raffaella Aldigeri, Alessandro Invernizzi, Luca de Simone, Fabrizio Gozzi, Alessandro De Fanti, Michela Cappella, Chantal Adani, Alberto Neri, Antonio Moramarco, Michele De Maria, Carlo Salvarani, Luigi Fontana, Luca Cimino
Summary: Biological drug treatment can improve visual outcomes after cataract surgery in patients with JIA-associated uveitis, but does not significantly reduce postoperative ocular complications. There was a significant difference in the improvement of corrected distance visual acuity between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Jie Zheng, Yong Wang, Jun Hu
Summary: This study explores the shared gene signatures and potential molecular mechanisms of polyarticular juvenile idiopathic arthritis (pJIA) and autoimmune uveitis (AU) through data analysis and functional enrichment analysis. Neutrophil degranulation may be considered a shared pathogenic mechanism, and the roles of ARID1A gene and hsa-miR-146a are worthy of further study. Additionally, periodic inspection of kidney function is also important.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Maria Pia Paroli, Alessandro Abbouda, Giuseppe Albanese, Massimo Accorinti, Alessandro Falcione, Leopoldo Spadea, Marino Paroli
Summary: In this retrospective study, patients over 16 years old with JIA-associated active uveitis were evaluated. The study found that some patients still had persistent uveitis in adulthood, which could lead to severe visual impairment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Karoline Baquet-Walscheid, Kai Rothaus, Martina Niewerth, Jens Klotsche, Kirsten Minden, Arnd Heiligenhaus
Summary: Data on uveitis in juvenile psoriatic arthritis (JPsA) are scarce. Patients with JPsA-associated uveitis (JPsA-U) have similar characteristics to uveitis patients in other categories of juvenile idiopathic arthritis (JIA). Children with early-onset JPsA are at a higher risk for ocular involvement.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Saira Akbarali, Jugnoo S. Rahi, Andrew D. Dick, Kiren Parkash, Katie Etherton, Clive Edelsten, Xiaoxuan Liu, Ameenat L. Solebo
Summary: This study investigates the feasibility, acceptability, and performance of optical coherence tomography (OCT) imaging-based diagnosis of uveitis in children with juvenile idiopathic arthritis (JIA). The results show that OCT imaging is feasible, acceptable to patients, and has potential to transform pediatric practice in monitoring JIA uveitis. Manual image cell count using anterior segment OCT has high sensitivity and specificity for diagnosis of active inflammation. Further research is needed to determine the validity and cost-effectiveness of OCT imaging-based disease monitoring.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Ophthalmology
Sanna Leinonen
Summary: This perspective aimed to explore the screening of uveitis in Nordic children with JIA, summarizing the predictors and recommendations for JIA-uveitis screening. Younger age, positive antinuclear antibody titre, specific subtypes of JIA, and shorter duration of JIA are predictors of uveitis in JIA. Methotrexate and monoclonal TNF inhibitor treatment can reduce the risk of JIA-uveitis. Guidelines for screening intervals and length were prepared based on known risk factors and the Nordic population.
ACTA OPHTHALMOLOGICA
(2023)
Article
Rheumatology
Gloria Fadanelli, Anna Agazzi, Fabio Vittadello, Alessandra Meneghel, Francesco Zulian, Giorgia Martini
Summary: Most children with linear scleroderma respond well to methotrexate treatment, achieving complete and long-lasting remission. The overall aesthetic and functional sequelae are moderate, likely due to early establishment of tissue damage and stabilization of the damage through treatment. Early diagnosis, methotrexate treatment, and long-term monitoring are crucial for improving outcomes and promptly identifying flares.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Giovanni Civieri, Biagio Castaldi, Giorgia Martini, Alessandra Meneghel, Ornella Milanesi, Francesco Zulian
Summary: Speckle tracking echocardiography (STE) is more sensitive in identifying cardiac involvement in juvenile systemic sclerosis (JSSc) patients and can detect dysfunction earlier than traditional techniques. Over time, there was a gradual worsening of left ventricular global longitudinal strain (LV-GLS) which preceded the decrease in ejection fraction (EF).
Article
Rheumatology
Giorgia Martini, Laura Saggioro, Roberta Culpo, Fabio Vittadello, Alessandra Meneghel, Francesco Zulian
Summary: This study investigated the safety and efficacy of MMF in patients with severe or MTX-refractory juvenile localized scleroderma. After a mean follow-up of 9.4 years, both MMF and MTX were effective in controlling disease activity. While there was no significant difference in relapse-free survival between the two groups, MMF may induce more persistent remission.
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Nikolay Tzaribachev, Gabriel Vega-Cornejo, Ingrid Louw, Rolando Cimaz, Jason Dare, Graciela Espada, Enrique Faugier, Manuel Ferrandiz, Valeria Gerloni, Pierre Quartier, Clovis Artur Silva, Linda Wagner-Weiner, Yash Gandhi, Julie Passarell, Marleen Nys, Robert Wong, Alberto Martini, Daniel J. Lovell
Summary: In patients aged 2-17 years with pJIA, no evidence of association between higher levels of exposure to IV ABA or SC ABA and incidence of infection was observed.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Pediatrics
Alessandra Meneghel, Giorgia Martini, Angela Amigoni, Andrea Pettenazzo, Massimo Padalino, Francesco Zulian
Summary: This case report highlights the importance of early aggressive treatment in refractory life-threatening sJIA-related MAS and provides evidence on the safety and efficacy of high dose intravenous Anakinra in acute myocarditis requiring VA-ECMO support.
FRONTIERS IN PEDIATRICS
(2021)
Editorial Material
Rheumatology
Teresa Giani, Maurizio Gattinara, Rolando Cimaz
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Letter
Dermatology
Enrico Valerio, Ramon Grimalt, Francesco Zulian, Vera Perri, Mario Cutrone
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Ophthalmology
Francesca Tirelli, Maria Elisabetta Zannin, Fabio Vittadello, Jacopo Agnolucci, Monica Mazzarolo, Francesco Zulian
Summary: The study evaluated the long-term efficacy of MTX monotherapy in patients with JIA-U and found that although effective in the early stages, MTX showed poor disease control in the long term, with many patients eventually needing biologic agents for treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Rheumatology
Arianna De Matteis, Claudia Bracaglia, Denise Pires Marafon, Anna Lucia Piscitelli, Maria Alessio, Roberta Naddei, Francesca Orlando, Giovanni Filocamo, Francesca Minoia, Angelo Ravelli, Jessica Tibaldi, Rolando Cimaz, Achille Marino, Gabriele Simonini, Maria Vincenza Mastrolia, Francesco La Torre, Ilaria Tricarico, Francesco Licciardi, Davide Montin, Maria Cristina Maggio, Clotilde Alizzi, Giorgia Martini, Adele Civino, Romina Gallizzi, Alma Nunzia Olivieri, Francesca Ardenti Morini, Giovanni Conti, Fabrizio De Benedetti, Manuela Pardeo
Summary: This study used real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with sJIA. The results showed that canakinumab was effective in treating sJIA and had no serious adverse events. The history of MAS and higher number of active joints were associated with poorer treatment outcomes.
Article
Rheumatology
Francesco Zulian, Gloria Lanzoni, Biagio Castaldi, Alessandra Meneghel, Francesca Tirelli, Elisabetta Zanatta, Giorgia Martini
Summary: This study reports the first case series of patients with ssJSSc, a rare condition in childhood characterized by no skin involvement. Compared to classic JSSc, ssJSSc showed a longer diagnostic delay, higher frequency of cardiac involvement, and worse outcomes.
Review
Pediatrics
Stefania Costi, Teresa Giani, Francesco Orsini, Rolando Cimaz
Summary: Osteoporosis can affect young individuals, although it is rare. Bone mass increases during childhood and peaks between the second and third decades, then gradually declines. Various factors, such as genetic disorders, chronic illnesses, and certain medications, can impact bone health. Diagnosis in young patients is based on the criteria defined by the International Society for Clinical Densitometry (ISCD) in 2013. Identification and monitoring of high-risk factors are important. Simple interventions, such as addressing underlying causes, minimizing negative effects of medications on bone, or increasing calcium and vitamin D intake, can protect bone mass. Pharmacological treatment may be necessary in selected cases. Bisphosphonates are the main therapeutic agent for children with significant skeletal fragility and can also be used for other bone conditions. Denosumab, an anti-RANKL antibody, could be an alternative treatment option. Long-term effects and safety of denosumab in children are currently being evaluated in clinical trials.
Review
Acoustics
Orazio De Lucia, Teresa Giani, Roberto Caporali, Rolando Cimaz
Summary: This systematic review analyzed the predictive value of ultrasound (US) in assessing subclinical synovitis in juvenile idiopathic arthritis (JIA). The study found that US may have the potential to predict flare in JIA, but more research is needed to draw definitive conclusions.
MEDICAL ULTRASONOGRAPHY
(2022)
Article
Rheumatology
Sabrina Acierno, Francesca Angrisani, Achille Marino, Roberto Felice Caporali, Rolando Cimaz, Teresa Giani
Summary: CRMO is a bone inflammatory disorder characterized by osteolytic lesions, with no standardized therapies available. Treatment with an anti-IL-1 beta antibody may show promise in managing the condition.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Pediatrics
Alessandra Meneghel, Giorgia Martini, Marta Balzarin, Nadia Zabadneh, Michele Fastiggi, Francesca Tirelli, Francesco Zulian
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a serious condition caused by SARS-COV-2 infection, characterized by persistent fever, multiorgan dysfunction, and increased inflammation. We report a series of four patients with self-limiting MIS-C, who did not require immunomodulatory treatment. There is limited knowledge about self-limiting MIS-C and no information on medium- and long-term outcomes for this subset of patients has been reported.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Federico Baronio, Stefano Zucchini, Francesco Zulian, Mariacarolina Salerno, Rossella Parini, Alessandro Cattoni, Federica Deodato, Alberto Gaeta, Carla Bizzarri, Serena Gasperini, Andrea Pession
Summary: Diagnostic delay is common in MPS Ia due to the rarity of the disease and the variability of clinical presentation. A multidisciplinary panel developed an algorithm to improve awareness and reduce diagnostic delay of MPS Ia in pediatric endocrinologists.
MEDICINA-LITHUANIA
(2022)