Article
Public, Environmental & Occupational Health
Yongpeng Zhang, Yaxing Wang, Jinqiong Zhou, Qian Wang, Yanni Yan, Xuan Yang, Jingyan Yang, Wenjia Zhou, Ping Wang, Chang Shen, Ming Yang, Yanan Luan, Jinyuan Wang, Shouling Wu, Shuohua Chen, Haiwei Wang, Lijian Fang, Qianqian Wan, Jingyuan Zhu, Zihan Nie, Yuning Chen, Ying Xie, Jost B. Jonas, Wenbin Wei
Summary: This study investigated the prevalence of age-related macular degeneration (AMD) in patients with diabetes mellitus (DM) and diabetic retinopathy (DR) and found that DR is an independent risk factor for dry AMD. The study highlights the importance of controlling diabetes and slowing down the development of DR to reduce the prevalence of AMD in diabetic patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Liv Tybjaerg Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt, Borge Gronne Nordestgaard
Summary: The study showed that elevated plasma apolipoprotein A1 and HDL cholesterol, as well as lower LDL cholesterol, are associated with increased risk of AMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biology
Thomas H. Julian, Johnathan Cooper-Knock, Stuart MacGregor, Hui Guo, Tariq Aslam, Eleanor Sanderson, Graeme C. M. Black, Panagiotis Sergouniotis, Lois E. H. Smith
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness, and this study aims to identify causal factors and potential therapeutic targets for AMD through a phenome-wide Mendelian randomisation (MR) study. The results of this study support several putative causal factors for AMD and provide avenues for future translational research.
Article
Ophthalmology
Jacqueline Hamati, Sai Prashanthi, Raja Narayanan, Niroj Sahoo, Anthony Vipin Das, Padmaja Kumari Rani, Umesh Chandra Behera, Rohit Khanna, Gudlavalleti V. S. Murthy
Summary: This study analyzed big data of risk and protective factors in patients with AMD and reported the age-adjusted prevalence in a geriatric Indian cohort in a hospital setting. The results showed a low prevalence of AMD above the age of 60, with more patients presenting with wet AMD compared to dry AMD. Smoking was not associated with AMD, while cataract surgery was associated with a higher prevalence of AMD.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Health Care Sciences & Services
Shih-Han Hung, Sudha Xirasagar, Tung-Mei Tammy Kuang, Wei-Wen Chang, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin
Summary: This study found a statistically significant association between thyroid dysfunction and age-related macular degeneration (AMD). Patients with hyperthyroidism or hypothyroidism were at higher risk of developing AMD. The results suggest that patients with thyroid disorder should receive regular eye checkups even if their vision is normal.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Ophthalmology
Krishna M. Gokhale, Nicola J. Adderley, Anuradhaa Subramanian, Wen Hwa Lee, Diana Han, Jesse Coker, Tasanee Braithwaite, Alastair K. Denniston, Pearse A. Keane, Krishnarajah Nirantharakumar
Summary: This study aimed to explore the relationship between metformin use and the development of AMD in patients with type 2 diabetes in the UK. The results showed that there was no association between the use of metformin and the risk of developing AMD, regardless of whether other antidiabetic medications were also used.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
David B. Rein, John S. Wittenborn, Zeb Burke-Conte, Rohit Gulia, Toshana Robalik, Joshua R. Ehrlich, Elizabeth A. Lundeen, Abraham D. Flaxman
Summary: This study estimated the prevalence of early and late-stage age-related macular degeneration (AMD) in the United States, stratified by various factors. The results showed a higher prevalence of early-stage AMD and a similar prevalence of late-stage AMD compared to previous studies. These findings are important for guiding public health practices.
JAMA OPHTHALMOLOGY
(2022)
Review
Environmental Sciences
Lei Liu, Cong Li, Honghua Yu, Xiaohong Yang
Summary: Age-related macular degeneration (AMD) is a major cause of visual impairments and blindness in the elderly. Recent research has shown that air pollution may affect the development of eye diseases, including AMD. Exposure to air pollutants can accelerate or worsen the incidence and prevalence of AMD by interfering with inflammatory response and affecting lipid metabolism and oxidative stress in the macula. Therefore, more attention should be given to understanding the impact of global ambient air pollution on AMD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Ophthalmology
Matthias M. Mauschitz, Robert P. Finger
Summary: Age-related macular degeneration (AMD) and cardiovascular disease (CVD), both associated with aging, share common risk factors and comorbidity. Smoking, diet, and low levels of physical activity are common risk factors for both diseases. AMD patients have a higher risk for CVD compared to the general older population. However, the complexity of these diseases complicates research on their relation, requiring cautious interpretation of study results.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Alaa Din Abdin, Machteld Devenijn, Roxana Fulga, Achim Langenbucher, Berthold Seitz, Hakan Kaymak
Summary: This study aimed to investigate the prevalence of geographic atrophy (GA) in advanced age-related macular degeneration (AMD) and the proportion of eyes eligible for treatment with intravitreal pegcetacoplan. A retrospective cross-sectional study was conducted, including all AMD patients who visited a specific center in 2021. It was found that at least a quarter of eyes with advanced AMD would meet the indication criteria for treatment with pegcetacoplan, and neovascular AMD was associated with a higher likelihood of foveal involvement in GA compared to dry AMD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Amirhossein Roshanshad, Romina Roshanshad, Seyed Ali Moosavi, Ali Ardekani, Sara Sadat Nabavizadeh, Reza Fereidooni, Hossein Ashraf, Hossein Molavi Vardanjani
Summary: This study investigated the prevalence of age-related macular degeneration (AMD) among Iranians and its determinants. The results showed a high prevalence of AMD in the Iranian population, with an increasing trend as age increases. The study emphasizes the importance of adopting preventive and screening policies to reduce the burden of the disease in the future decades.
Article
Medicine, General & Internal
Yi-Hsiang Chiu, Jehn-Yu Huang, Ya-Ping Huang, Shin-Liang Pan
Summary: This study found that individuals with osteoarthritis have an increased risk of developing age-related macular degeneration (AMD), regardless of age and sex.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Benedicte M. J. Merle, Stephanie Barthes, Catherine Feart, Audrey Cougnard-Gregoire, Jean-Francois Korobelnik, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Cecile Delcourt
Summary: B vitamins may protect against age-related macular degeneration (AMD), as suggested by a cohort study on older adults in Bordeaux, France. The study found a significant association between normal serum folate levels and a high dietary intake of B5 and B6 with a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help reduce vision loss due to AMD.
Article
Nutrition & Dietetics
Benedicte M. J. Merle, Audrey Cougnard-Gregoire, Jean-Francois Korobelnik, Wolfgang Schalch, Stephane Etheve, Marie-Benedicte Rougier, Catherine Feart, Cecilia Samieri, Marie-Noelle Delyfer, Cecile Delcourt
Summary: The study found that higher plasma lutein concentrations were associated with a reduction in the risk of developing advanced AMD, suggesting a potential protective effect of lutein and zeaxanthin on AMD.
Article
Food Science & Technology
Nguyen Dao, Thilini Thrimawithana, Terrence J. Piva, Danilla Grando, Huynh Tien
Summary: Age-related macular degeneration (AMD) is a chronic disease that causes blindness in older adults and has a significant economic impact on the healthcare system. Carotenoids from plants, such as lutein, zeaxanthin, and mesozeaxanthin, accumulate in the macula and protect against light exposure, oxidation, and inflammation, making them a potential preventative and therapeutic treatment for AMD. The dose and duration of treatment with carotenoids are important factors that influence their protective effects and can potentially improve visual outcomes in AMD patients. This review discusses the application of carotenoid supplementation as a non-invasive alternative for the prevention and treatment of AMD.
JOURNAL OF FUNCTIONAL FOODS
(2023)