Article
Biodiversity Conservation
Lukas Gabor, Petra Simova, Petr Keil, Alejandra Zarzo-Arias, Charles J. Marsh, Duccio Rocchini, Marco Malavasi, Vojtech Bartak, Vitezslav Moudry
Summary: The representation of habitat in species distribution models is often used, but the binary presence/absence of suitable habitat might be a better predictor for some species than the continuous parameter of habitat area. The prevalence of the habitat and the biological role in a species' life history should be considered when using habitat as a predictor for species occurrences.
Article
Chemistry, Inorganic & Nuclear
Jana Jurakova, Jana Dubnicka Midlikova, Jakub Hruby, Andrii Kliuikov, Vinicius Tadeu Santana, Jan Pavlik, Jan Moncol', Erik Cizmar, Milan Orlita, Ivan Mohelsky, Petr Neugebauer, Denis Gentili, Massimiliano Cavallini, Ivan Salitros
Summary: Four pentacoordinate complexes have been synthesized and their structures determined. The magnetic properties of the compounds were investigated, and the relationship between geometry and orbital ordering was discussed. Theoretical calculations were in good agreement with experimental data. Wet lithographic technique was used to evaluate the processability of the complexes and the preparation of microstructured films.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Editorial Material
Oncology
Alexander E. Perl, Paresh Vyas
Summary: Two publications provide new insights into risk stratification in patients with acute myeloid leukemia and mutations in IDH1, IDH2, or FLT3 who received initial therapy with venetoclax and azacitidine, setting the stage for future trials integrating molecularly targeted therapy with this new standard regimen.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Krzysztof Cipora, Flavia H. Santos, Karin Kucian, Ann Dowker
Summary: In this paper, the authors discuss the widely accepted claims about mathematics anxiety (MA) and propose areas of focus for future research. These areas include theoretical clarifications, construct validity, the discrepancy between state and trait MA, prevalence of MA and establishing external criteria, effects of MA in different groups, applications in classrooms and policy, effects outside educational settings, and consequences for mental health and well-being.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Engineering, Environmental
Ariele Zanfei, Andrea Menapace, Bruno M. Brentan, Robert Sitzenfrei, Manuel Herrera
Summary: This paper proposes a breakthrough approach for calibrating hydraulic models through a graph machine learning approach. The main idea is to create a graph neural network metamodel to estimate the network behaviour based on a limited number of monitoring sensors. Through this process, it is possible to estimate the uncertainty that is transferred from the few available measurements to the final hydraulic model.
Article
Engineering, Biomedical
Bojiao Tang, Xiaoling Xie, Ruhui Yang, Sijie Zhou, Ronggui Hu, Jiayao Feng, Qinxiang Zheng, Xingjie Zan
Summary: The hydrophobicity of nanoparticles plays a significant role in their ability to penetrate biological barriers. This study successfully encapsulated the protein drug Ava by decorating hydrophobic amino acid tyrosine (Y) onto a peptide chain, resulting in improved bioavailability and therapeutic outcomes.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Yunlong Yang, Junmu Zhong, Dongmei Cui, Lasse D. Jensen
Summary: This article comprehensively discusses the etiology and mechanisms of ocular surface neovascularization, as well as emerging animal models and drug delivery strategies that facilitate its management.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Shirin Tavakoli, Jooseppi Puranen, Sina Bahrpeyma, Veera E. Lautala, Suvi Karumo, Tatu Lajunen, Eva M. del Amo, Marika Ruponen, Arto Urtti
Summary: Choroidal neovascularization (CNV) is a common vascular disorder that affects vision in the elderly population. In this study, sunitinib-loaded liposomes were developed to block the signaling pathway of neovascularization by inhibiting the tyrosine kinase of vascular endothelial growth factor receptors (VEGFRs). The liposomes effectively encapsulated sunitinib and released it over a period of at least 3 days. Compared to the solubilized form, intravitreal injection of sunitinib-loaded liposomes showed promising efficacy in inhibiting CNV associated with age-related macular degeneration (AMD).
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Green & Sustainable Science & Technology
Mian Wang, Jamie Marsden, Ezgi Oguz, Briony Thomas, Arminda Paco
Summary: This study explores how gamification can create engaging experiences within physical retail environments and provides practical implications for achieving sustainable brand experiences by shifting customers from passive observers to active participants, strengthening emotional connections, prolonging footfall and engagement duration, and integrating physical and online platforms.
Review
Chemistry, Medicinal
Die Jiang, Ting Xu, Lei Zhong, Qi Liang, Yonghe Hu, Wenjing Xiao, Jianyou Shi
Summary: Angiogenesis is a vital biological process for body growth and development, wound healing, and tissue formation. Dysregulation of VEGFR signaling can lead to diseases, making it a crucial research area for disease treatment. Currently, anti-VEGF drugs used in ophthalmology have limitations, and there is a need to develop small molecule inhibitors of VEGFR for the targeted treatment of ocular neovascularization diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Linguistics
Aditi Bhatia, Andrew S. Ross
Summary: This article analyzes the narrative of the Hong Kong anti-extradition bill protests on Twitter, using a multi-perspective framework to explore argument construction and legitimacy. The hashtag narrative on Twitter mainly revolves around the dimensions of historicity, linguistic and semiotic action, and social impact.
JOURNAL OF LANGUAGE AND POLITICS
(2022)
Article
Multidisciplinary Sciences
De-Wei Peng, Chun-Lin Lan, Ling-Qin Dong, Meng-Xi Jiang, Huan Xiao, Robert J. D'Amato, Zai-Long Chi
Summary: MicroRNA-29a (miR-29a) has been found to play an inhibitory role in ocular neovascularization. Deletion of the miR-29a gene in mice promotes angiogenesis in preclinical disease models, while administration of miR-29a improves pathological neovascularization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Chengxin Zhou, Fengyang Lei, Jyoti Sharma, Pui-Chuen Hui, Natalie Wolkow, Claes H. Dohlman, Demetrios G. Vavvas, James Chodosh, Eleftherios I. Paschalis
Summary: This study developed a thermosensitive drug delivery system (DDS) for sustained delivery of TNF-alpha and VEGF inhibitors to the eye, aiming to provide a clinically feasible and practical therapy for multiocular protection following ocular injury. The study found that the subconjunctival administration of the dual anti-TNF-alpha/anti-VEGF DDS achieved sustained delivery of antibodies to ocular tissues for 3 months, preventing corneal neovascularization and improving corneal re-epithelialization, while reducing immune cell infiltration and preventing damage to the retina and optic nerve. This therapeutic approach has the potential to significantly improve outcomes for severe ocular injuries and retinal vascular diseases.
Article
Hematology
Devy Deliyanti, William A. Figgett, Thomas Gebhardt, Joseph A. Trapani, Fabienne Mackay, Jennifer L. Wilkinson-Berka
Summary: CD8(+) T cells contribute to pathological angiogenesis by migrating into the retina and releasing cytokines and cytotoxic factors. CXCR3 is identified as the key pathway for the migration of CD8(+) T cells into the retina, and blocking CXCR3 reduces the number of CD8(+) T cells and retinal vasculopathy. This research reveals the important role of CD8(+) T cells in retinal inflammation and vascular disease, and reducing CD8(+) T cells could be a potential treatment for neovascular retinopathies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Polymer Science
Jun Zhang, Kun Xi, Guohua Deng, Xi Zou, Peirong Lu
Summary: Ocular alkali burns can stimulate the release of neutrophil extracellular traps (NETs) and induce neovascularization, which hinders ocular surface reconstruction and functional repair. In this study, a composite hydrogel was developed to sustainably regulate NETs and reduce neovascularization, thereby promoting ocular surface reconstruction.