Cost-effectiveness analysis of FDG PET-CT in the management of pulmonary metastases from malignant melanoma

Objectives. Most guidelines consider FDG PET-CT to detect occult extra-pulmonary disease prior to lung metastasectomy. A cost-effectiveness analysis, using a Markov model over a 10 year period, was performed to compare two different surveillance programs, either PET-CT or whole-body CT, in patients with suspected pulmonary metastasised melanoma. Methods. Data from published studies provided probabilities for the model. Complication and care costs were obtained from standardised administrative databases from 19 hospitals identified by DRG codes (reported in 2009 Euros). For the cost calculation of PET-CT we performed a microcosting analysis. All costs and benefits were yearly discounted at respectively 3% and 1.5% Outcomes included life-months gained (LMG) and the number of futile surgeries avoided. Cost-effectiveness ratios were in Euros per LMG. Univariate and probabilistic sensitivity analyses addressed uncertainty in all model parameters. Results. The PET-CT strategy provided 86.29 LMG (95%, CI: 81.50-90.88 LMG) at a discounted cost of (sic)3 974 (95% CI: (sic)1 339-12 303), while the conventional strategy provided 86.08 LMG (95% Cl: 81.37-90.68 LMG) at a discounted cost of (sic)5 022 (95% CI: (sic)1 378-16 018). This PET-CT strategy resulted in a net saving of (sic)1 048 with a gain of 0.2 LMG. Based on PET-CT findings, 20%, of futile surgeries could be avoided. Conclusion. Integrating PET-CT in the management of patients with high risk MM appears to be less costly and more accurate by avoiding futile thoracotomies in one of five patients as well as by providing a small survival benefit at 10 years.