Article
Biochemistry & Molecular Biology
Dora B. Balogh, Agnes Molnar, Arianna Degi, Akos Toth, Lilla Lenart, Adar Saeed, Adrienn Barczi, Attila J. Szabo, Laszlo J. Wagner, Gyorgy Reusz, Andrea Fekete
Summary: This study suggests that low-dose renin-angiotensin-aldosterone system inhibitors (RAASis) have cardioprotective and antifibrotic benefits in type 1 diabetes mellitus (T1DM). Among the RAASis, mineralocorticoid receptor antagonists, particularly eplerenone, may offer superior efficacy in halting both arterial and myocardial injuries in T1DM compared to angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Abhipree Sharma, Miles De Blasio, Rebecca Ritchie
Summary: Cardiomyopathy is a significant cardiac complication of diabetes, independent of other heart diseases. Pathological cardiac fibrosis, capillary rarefaction, and myocardial apoptosis contribute to its development. There are sex differences in the occurrence and treatment effects of diabetes, heart failure, and myocardial fibrosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ravit Cohen-Segev, Omri Nativ, Safa Kinaneh, Doron Aronson, Aviva Kabala, Shadi Hamoud, Tony Karram, Zaid Abassi
Summary: Congestive heart failure (CHF) is associated with impaired kidney function. This study examined the effects of Ang 1-7 on kidney function in rats with CHF and found that Ang 1-7 has beneficial effects on renal and cardiac function in CHF rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Matus Sykora, Vojtech Kratky, Libor Kopkan, Narcisa Tribulova, Barbara Szeiffova Bacova
Summary: The extracellular matrix (ECM) plays a vital role in heart muscle function. Overload-induced ECM remodeling leads to impaired cardiomyocyte adhesion and electrical coupling, resulting in cardiac dysfunction and arrhythmias. This study investigated the signaling pathways of ECM and connexin-43 (Cx43) in rat hearts with hemodynamic overload, as well as the potential protective effects of angiotensin (1-7) (Ang (1-7)) in preventing adverse myocardial remodeling. The findings suggest that Ang (1-7) has cardio-protective and anti-fibrotic effects in conditions of cardiac volume overload.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Zheng Li, Yi Shi, Yiyuan Xia, Lida Wu, Hui Li, Rong Zhou, Xiaofei Gao, Hongsong Zhang, Xiaoping Jin, Junxia Zhang
Summary: The study aims to explore the clinical characteristics and prognosis of diabetic patients with different types of heart failure. It was found that compared to patients with HFrEF, patients with HFpEF had a shorter duration of type 2 diabetes, younger age, and were more likely to be associated with hypertension and non-obstructive coronary artery disease. Survival analysis showed that patients with HFpEF had a better composite endpoint prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andreas Angelopoulos, Evangelos Oikonomou, Alexios S. Antonopoulos, Panagiotis Theofilis, Konstantinos Kalogeras, Paraskevi Papanikolaou, George Lazaros, Gerasimos Siasos, Dimitris Tousoulis, Konstantinos Tsioufis, Charalambos Vlachopoulos
Summary: This study aimed to identify factors related to heart failure symptoms and functional capacity in patients with hypertrophic cardiomyopathy (HCM). Patients were categorized based on functional capacity and symptoms, and echocardiographic measurements were conducted. The results showed that the symptomatic group had higher maximum LVOT gradient, RVSP, and E/e' ratio, and lower TASV compared to the asymptomatic group. Additionally, the RVAC calculated with the TASV/RVSP ratio was lower in the symptomatic group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphael Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Filippo Annoni
Summary: The aim of this study was to investigate the effects of Ang-(1-7) infusion on the development and severity of septic shock. The results showed that early Ang-(1-7) infusion can prevent the development of septic shock, reduce norepinephrine requirements, limit the increase of interleukin-6 levels, and prevent renal dysfunction.
Review
Biochemistry & Molecular Biology
Petra Grubic Rotkvic, Zrinka Planinic, Ana-Marija Liberati Prso, Jozica Sikic, Edvard Galic, Luka Rotkvic
Summary: Diabetic cardiomyopathy is a specific form of cardiomyopathy characterized by myocardial fibrosis, cardiomyocyte hypertrophy, and apoptosis, independent of diabetic complications. Its pathophysiology is complex and poorly understood, with no specific therapeutic guidelines established. Diagnosis is challenging, requiring exclusion of other possibilities, and treatment involves pharmacotherapy targeting different pathophysiological pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Raffaele Marfella, Celestino Sardu, Gelsomina Mansueto, Claudio Napoli, Giuseppe Paolisso
Summary: Growing interest has been focused on defining the worsening effects of diabetes on the cardiovascular system, particularly the high incidence of heart failure in diabetic patients. Preclinical models have been developed to study the harmful effects of high blood sugar and insulin resistance, but understanding of the pathogenic and histological changes of diabetic cardiomyopathy in humans remains limited. A literature analysis suggests that lipotoxic-related events may play a central role in the development of human diabetic cardiomyopathy, but the main challenge lies in the lack of availability of heart specimens for research purposes.
ACTA DIABETOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Pratyush Narayan, Elefterios Trikantzopoulos, Eleonora Mezzaroma, Adolfo G. Mauro, Habeebah Vohra, Antonio Abbate, Stefano Toldo
Summary: IL-1 plays a critical role in aging-related heart failure with preserved ejection fraction (HFpEF), and mice lacking the IL-1RI receptor are protected from aging-related cardiac changes.
Review
Endocrinology & Metabolism
Marko Kumric, Tina Ticinovic Kurir, Josip A. Borovac, Josko Bozic
Summary: DCM, defined as cardiomyopathy in diabetes patients without coronary artery disease or hypertension, is recognized as a significant cause of morbidity and mortality. Various expert groups have struggled to identify suitable biomarkers for DCM diagnosis, with limited success. Some promising biomarkers identified include long noncoding ribonucleic acids, soluble form of suppression of tumorigenicity 2, and galectin-3, which accurately correlate with early stages of DCM.
WORLD JOURNAL OF DIABETES
(2021)
Review
Biochemistry & Molecular Biology
Kuo-Li Pan, Yung-Chien Hsu, Shih-Tai Chang, Chang-Min Chung, Chun-Liang Lin
Summary: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood sugar due to insufficient insulin secretion, resistance, or both. The cardiovascular complications of DM are the leading cause of morbidity and mortality in diabetic patients. DM cardiomyopathy is a distinct form of heart muscle disease characterized by dysfunction without coronary artery disease, hypertension, or valve disease. Cardiac fibrosis plays a key role in DM cardiomyopathy, leading to heart failure and increased mortality. Non-invasive imaging techniques such as echocardiography, CT, MRI, and nuclear imaging can be used to assess the severity of cardiac fibrosis in DM cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Teresa Salvatore, Pia Clara Pafundi, Raffaele Galiero, Gaetana Albanese, Anna Di Martino, Alfredo Caturano, Erica Vetrano, Luca Rinaldi, Ferdinando Carlo Sasso
Summary: Research has shown that individuals with diabetes mellitus have a higher risk of heart failure compared to non-diabetic individuals, and diabetic cardiomyopathy may be a key factor. Metabolic abnormalities, mitochondrial damage, oxidative stress, and other factors may lead to extracellular remodeling and hypertrophy in the diabetic heart, resulting in left ventricular diastolic and systolic dysfunction.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, Research & Experimental
Magdalena Jasinska-Stroschein
Summary: The pathogenesis of diabetic cardiomyopathy (DCM) is not fully understood, and there is no consensus on therapeutic options. Experimental studies on rodents provide valuable data at the preclinical stage. This paper describes and compares various experimental protocols intended to mimic human DCM. The protocols vary in their presentation of DCM according to different parameters, such as hemodynamic, echocardiographic, histopathologic, and metabolic measures.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Ibrahim Elmadbouh, Dinender K. Singla
Summary: The study demonstrated that BMP-7 could attenuate inflammation-induced pyroptosis and adverse cardiac remodeling to improve heart function in diabetic cardiomyopathy, showing significant potential as a future therapy for diabetic patients.
