Article
Biochemistry & Molecular Biology
Anna Majkowska, Karla E. Inostroza-Brito, Mariel Gonzalez, Carlos Redondo-Gomez, Alistair Rice, Jose Carlos Rodriguez-Cabello, Armando E. Del Rio Hernandez, Alvaro Mata
Summary: The study demonstrates the possibility to generate coassembling tubular membranes with distinct structures, properties, and bioactivity by minor modifications in the molecular structures of peptide amphiphiles and elastin-like recombinamers.
Article
Gastroenterology & Hepatology
Emily Becker, Mark Dedden, Christine Gall, Maximilian Wiendl, Arif Bulent Ekici, Anja Schulz-Kuhnt, Anna Schweda, Caroline Voskens, Ahmed Hegazy, Francesco Vitali, Raja Atreya, Tanja Martina Mueller, Imke Atreya, Markus F. Neurath, Sebastian Zundler
Summary: This study investigated the non-linear exposure-efficacy characteristics of vedolizumab in IBD patients. The research found that blocking T-Eff cell trafficking with vedolizumab while allowing residual homing of T-Reg cells could be a strategy to optimize treatment outcomes. These findings were supported by data from Gemini II and III trials.
Article
Biochemistry & Molecular Biology
Marcin Niziol, Justyna Zinczuk, Konrad Zareba, Katarzyna Guzinska-Ustymowicz, Anna Pryczynicz
Summary: The study found significant differences in the expression of TNS1, TNS2, and TNS3 proteins in different types of gastric cancer patients, with TNS1 associated with tumor type and metastasis, TNS2 associated with peritumoral inflammation and H. pylori infection, and TNS3 related to tumor differentiation.
Article
Reproductive Biology
Seid Mohammed, Mohanned Naif Alhussien, Ajay Kumar Dang
Summary: The study evaluated the expression changes of relevant genes in blood neutrophils during pregnancy in dairy cows and found that neutrophils play a critical role in embryo implantation and pregnancy maintenance. The results contribute to uncovering the mechanism of neutrophil-associated immunological infertility in bovines.
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Byeong Gwan Song, Su Yeon Kwon, Jae Won Kyung, Eun Ji Roh, Hyemin Choi, Chang Su Lim, Seong Bae An, Seil Sohn, Inbo Han
Summary: Synaptic cell adhesion molecules (SynCAMs), specifically SynCAM3, play a crucial role in synapse formation and maintenance as well as synaptic plasticity regulation. Through its involvement in the connection between axons and astrocytes, SynCAM3 has been found to be associated with astrocytic scar formation following central nervous system (CNS) injuries. This study explores the impact of selective removal of SynCAM3 on spinal cord injury (SCI) outcomes, highlighting its role in the prevention of scar-forming astrocytes and promoting extracellular matrix (ECM) reconstitution, ultimately leading to improved functional recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Stachowicz
Summary: This article discusses the role of cell adhesion molecules in brain function, covering the basic physical and chemical properties of adhesion. It explores different cell adhesion molecules and their impact on physiological and pathological brain function, as well as methods for studying adhesion in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Priyanka K. Shetty, Nitin Gonsalves, Dinkar Desai, Siddharth Pandit, Chethan Aradhya, Mohammed Shahid, Shubhalakshmi, Sharan J. Shetty
Summary: This study aimed to evaluate the difference in immunohistochemical expression of syndecan-1 in different grades of oral squamous cell carcinoma (OSCC) patients and control group. The results showed that as cellular differentiation was lost, syndecan-1 expression decreased.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Cell Biology
Shaobo Zhang, Timothy Saunders
Summary: During the development of complex multicellular organisms, the robust formation of specific cell-cell connections is essential for precise tissue structure generation. Various mechanical cues, including differential adhesion and cell contractility, play a role in regulating cell-cell recognition and contact.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Joel Yong, Albert S. S. Mellick, John Whitelock, Joseph Wang, Kang Liang
Summary: The application of nanomotors for cancer diagnosis and therapy combined with precision nanomedicine offers a promising solution to the issues encountered in passive nanoparticle development. This article aims to provide nanomotor and nanomedicine researchers with a comprehensive understanding of cancer cell biology, biochemistry, cell membrane compositions, and extracellular surfaces. The review includes an overview of the state-of-the-art nanomotors for cancer therapy and diagnosis, recommendations for future research directions, and a biomolecular targeting toolbox for selecting targeting molecules and cell surface targets. It is hoped that this review will inspire and guide future nanomotor and nanomedicine research.
ADVANCED MATERIALS
(2023)
Article
Hematology
Farah Abdel Rahman, Sascha D'Almeida, Tina Zhang, Morad Asadi, Tarik Bozoglu, Dario Bongiovanni, Moritz von Scheidt, Steffen Dietzel, Edzard Schwedhelm, Rabea Hinkel, Karl Ludwig Laugwitz, Christian Kupatt, Tilman Ziegler
Summary: In sepsis, S1P acts as an antagonist to pericyte loss, vascular hyperpermeability, and systemic hypotension, resulting in increased survival in mice. By preserving the deposition of VE-cadherin and N-cadherin, S1P may achieve this effect through reduction of protein phosphorylation and increased nuclear translocation of MRTF-A.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Anna Junga, Mara Pilmane, Zane Abola, Olafs Volrats
Summary: The study found a moderate number of immune-reactive cells in congenital intra-abdominal adhesions. The positive correlation between TNF-alpha and PGP 9.5 supports the involvement of nerve ingrowth and inflammation maintenance in intra-abdominal adhesions. The imbalance between MMP-2 and TIMP-2 may lead to tissue fibrosis as a response to congenital peritoneal adhesions.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Angela Schippers, Jessica Huebel, Felix Heymann, Thomas Clahsen, Sreepradha Eswaran, Sarah Schlepuetz, Robin Pullen, Nikolaus Gassler, Klaus Tenbrock, Frank Tacke, Norbert Wagner
Summary: The absence of MAdCAM-1 or beta 7 integrin alleviates ConA-induced hepatitis in mice, suggesting that these molecules play a significant role in liver damage mediated by lymphocytes and innate immune cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Julia Caroline Michaeli, Sebastian Albers, Carolina de la Torre, Yannick Schreiner, Sara Faust, Thomas Michaeli, Daniel Tobias Michaeli, An Liying, Bernhard K. Kraemer, Ksenija Stach, Benito A. Yard
Summary: The study reveals that arterial and venous endothelial cells differ in their abilities to mediate inflammation and return to homeostasis. Gene expression profiles of these cells also show differences after an inflammatory stimulus. These findings have important implications for understanding the effects of systemic inflammation on endothelial cells in different organs.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Mengdie Yin, Chao Li, Jiali Jiang, Jingqing Le, Bangyue Luo, Fang Yang, Yifan Fang, Mingyue Yang, Zhenhua Deng, Wenxin Ni, Jingwei Shao
Summary: Atherosclerosis is a leading cause of human morbidity and mortality worldwide, characterized by pathological constriction of blood vessels due to chronic low-grade inflammation and lipid deposition. Cell adhesion molecules play a key role in regulating the inflammatory response and endothelial function, with potential therapeutic strategies based on CAM inhibitors showing promising results in combating atherosclerotic progression.
BIOCHEMICAL PHARMACOLOGY
(2021)