Article
Psychology, Clinical
Trisha Chakrabarty, Sophia Frangou, Ivan J. Torres, Ruiyang Ge, Lakshmi N. Yatham
Summary: This study investigated the association between accelerated or delayed age-related brain structural changes and cognition in early-stage BDI patients. The results showed that patients with delayed or accelerated brain changes had lower global cognitive scores and verbal memory scores compared to patients with age-congruent brain changes. These findings suggest a link between cognitive dysfunction and apparent delay in typical age-related brain changes in the early stage of BDI.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Brisa Sole, Cristina Varo, Carla Torrent, Laura Montejo, Esther Jimenez, Caterina del Mar Bonnin, Derek Clougher, Norma Verdolini, Silvia Amoretti, Flavia Piazza, Roger Borras, Edith Pomarol-Clotet, Pilar A. Saiz, Maria P. Garcia-Portilla, Eduard Vieta, Anabel Martinez-Aran
Summary: The study found that males performed better in different cognitive domains, while females excelled in verbal learning and memory recognition tasks. In terms of psychosocial functioning, no significant sex differences or group by sex interactions were observed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Tobin J. Ehrlich, Hanjoo Kim, Kelly A. Ryan, Scott A. Langenecker, Elizabeth R. Duval, Anastasia K. Yocum, Claudia Diaz-Byrd, Anna L. Wrobel, Olivia M. Dean, Sue M. Cotton, Michael Berk, Melvin G. McInnis, David F. Marshall
Summary: This study evaluated the relationship between childhood trauma and cognition in individuals diagnosed with bipolar disorder. It found that higher childhood trauma was associated with worse memory functioning in bipolar disorder patients. The study emphasizes the importance of understanding the long-term cognitive outcomes of childhood trauma in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Maria Yoldi-Negrete, Lino Palacios-Cruz, Elsa Tirado-Duran, Laura Ivonne Jimenez-Rodriguez, Joanna Jimenez-Pavon, Sandra Hernandez, Alejandro Aguilar, Ingrid Pamela Morales-Cedillo, Mariana Jimenez-Tirado, Ana Fresan-Orellana, Francisco Juarez Garcia, Claudia Becerra-Palars, Beatriz Camarena-Medellin
Summary: This study aims to identify demographic, clinical, cognitive, and genetic factors associated with poor functioning in patients with type I bipolar disorder (BD). The results showed that residual depressive symptoms, anxiety, cognitive complaints, and being a Met carrier were more frequent in the poor functioning group. Being a Met carrier and cognitive complaints were the most important predictors of poor functioning in type I BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Teresa Surace, Enrico Capuzzi, Alice Caldiroli, Alessandro Ceresa, Cecilia Maria Esposito, Ilaria Tagliabue, Martina Capellazzi, Francesca Legnani, Martina Di Paolo, Luisa Cirella, Francesco Zanelli Quarantini, Maria Salvina Signorelli, Eugenio Aguglia, Massimo Clerici, Massimiliano Buoli, Anna Maria Auxilia
Summary: This study investigated the relationship between lifetime suicide attempts and clinical factors/biochemical parameters in a large sample of bipolar patients. The results showed that bipolar patients with lifetime suicide attempts present unfavorable clinical features, and certain biochemical characteristics may serve as potential markers of suicidal behavior.
Article
Psychiatry
Hao Tang, Tingting Xiong, Jiabo Shi, Yu Chen, Xiaoxue Liu, Siqi Zhang, Huan Wang, Qing Lu, Zhijian Yao
Summary: The study aimed to investigate the relationship between rumination and suicide attempts, finding that both global rumination levels and reflection were higher in suicide attempters than non-suicide attempters; the results suggest that rumination may be a risk factor for suicide attempts.
Article
Psychology, Clinical
Baptiste Barbot, Henry Eff, Shira R. Weiss, James B. McCarthy
Summary: This study differentiates the unique effects of different types of early maltreatment on psychopathology, particularly mood disorders and psychotic symptoms, as well as histories of suicide attempts among psychiatrically hospitalized children and youth. The results showed direct and indirect relationships between various forms of abuse and history of suicide attempts, with mediation by bipolar disorders and psychotic symptoms.
CHILD AND ADOLESCENT MENTAL HEALTH
(2021)
Article
Psychiatry
D. Grillault Laroche, O. Godin, Y. Dansou, R. Belzeaux, B. Aouizerate, T. Burte, P. Courtet, C. Dubertret, E. Haffen, P. M. Llorca, E. Olie, P. Roux, M. Polosan, R. Schwan, M. Leboyer, F. Bellivier, C. Marie-Claire, B. Etain
Summary: The study found that psychiatric comorbidities and suicide attempts are highly prevalent in patients with Bipolar Disorder, and childhood maltreatment is associated with this. Patients with higher levels of childhood maltreatment are more likely to have multiple psychiatric comorbidities, which accumulate more rapidly before the onset of the disorder.
EUROPEAN PSYCHIATRY
(2022)
Article
Neuroimaging
Joseph J. Shaffer, Virginia Willour, Jess G. Fiedorowicz, Gary E. Christensen, Jeffrey D. Long, Casey P. Johnson, Samantha L. Schmitz, Aislinn J. Williams, John Wemmie, Vincent A. Magnotta
Summary: This study explored the relationship between suicide attempts and brain imaging measures in bipolar disorder, finding differences in brain activation and metabolism associated with suicide attempts. The study also revealed that the number of suicide attempts was related to differences in brain regions, indicating different neurobiological underpinnings for suicide history and number of attempts.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Julian Macoveanu, Viktoria Damgaard, Alexander Tobias Ysbaek-Nielsen, Sophia Frangou, Lakshmi N. Yatham, Trisha Chakrabarty, Marie Eschau Stougaard, Gitte Moos Knudsen, Maj Vinberg, Lars Vedel Kessing, Hanne Lie Kjaerstad, Kamilla Woznica Miskowiak
Summary: This study aimed to investigate the early longitudinal trajectories in brain structure and cognition in patients with recently diagnosed bipolar disorder (BD). The results showed that patients exhibited a decline in total white matter volume over time and had a larger amygdala volume at both baseline and follow-up. Patients also showed lower cognitive performance at both time points with no significant change over time. These findings suggest that cognitive impairment and amygdala enlargement may represent stable markers of early BD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tina R. Goldstein, John Merranko, Danella Hafeman, Mary Kay Gill, Fangzi Liao, Craig Sewall, Heather Hower, Lauren Weinstock, Shirley Yen, Benjamin Goldstein, Martin Keller, Michael Strober, Neal Ryan, Boris Birmaher
Summary: The study aims to establish a risk calculator for predicting the individualized risk for suicide attempts in early-onset bipolar disorder. The researchers selected readily assessed predictors from the literature and trained the risk calculator using boosted multinomial classification trees. The results show that the risk calculator holds promise for prospective identification of high-risk periods for suicide attempts in individuals with early-onset bipolar disorder.
Article
Geriatrics & Gerontology
Elad Omer, Yoram Braw, Revital Amiaz, Ramit Ravona-Springer
Summary: Older adults with bipolar disorder show more severe cognitive impairment, especially in executive functioning and memory, compared to older adults with unipolar depression. However, they may have relatively intact cognitive insight.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Psychiatry
Huan Wang, Rongxin Zhu, Shui Tian, Siqi Zhang, Zhongpeng Dai, Junneng Shao, Li Xue, Zhijian Yao, Qing Lu
Summary: By studying the dynamic functional connectivity in patients with bipolar disorder, the dysfunction of anterior cingulate cortex (ACC) was found to be relevant to suicide attempts. Specifically, suicide attempt patients showed significantly reduced dwell time in the suicide-related functional state, accompanied by a significantly increased functional connectivity strength between the right ACC and the regions within the subcortical network. These altered indicators were significantly correlated with suicide risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Rebecca Strawbridge, Rowena Carter, Francesco Saldarini, Dimosthenis Tsapekos, Allan H. Young
Summary: The study aimed to identify proteomic biomarker correlates of cognitive impairment in individuals with euthymic bipolar disorder. Results indicated that three specific proteins were significantly associated with cognitive deficits, while another protein was positively correlated with global cognitive performance.
Review
Psychiatry
T. Jordan Walter, Nina Pocuca, Jared W. Young, Mark A. Geyer, Arpi Minassian, William Perry
Summary: Most studies suggest that cannabis use in bipolar disorder is not significantly associated with cognitive impairment, but the scope of knowledge in this field is limited, requiring more systematic research.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Anna Butjosa, Judith Usall, Regina Vila-Badia, Gisela Mezquida, Manuel J. Cuesta, Elisa Rodriguez-Toscano, Silvia Amoretti, Antonio Lobo, Ana Gonzalez-Pinto, Ana Espliego, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Dani Berge, Miguel Bernardo
Summary: This study explored traumatic life events (TLEs) in first-episode psychosis (FEP) patients and healthy controls (HC), finding that FEP patients had a higher number of TLEs and a significantly higher proportion of individuals with multiple TLEs. There were no gender or age differences observed. Overall, the number and cumulative TLEs should be taken into account in the detection, epidemiology, and recovery processes of FEP.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Roger S. McIntyre, David G. Daniel, Eduard Vieta, Istvan Laszlovszky, Pascal J. Goetghebeur, Willie R. Earley, Mehul D. Patel
Summary: Post hoc analyses suggest that cariprazine may have potential benefits in improving cognitive symptoms in patients with bipolar I disorder and schizophrenia.
Article
Psychology, Clinical
Ana Catalan, Claudia Aymerich, Amaia Bilbao, Borja Pedruzo, Jose Luis Perez, Nerea Aranguren, Gonzalo Salazar de Pablo, Emily Hedges, Patxi Gil, Rafael Segarra, Ana Gonzalez-Pinto, Aranzazu Fernandez-Rivas, Lucia Inchausti, Philip McGuire, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres
Summary: COVID-19-related mortality and hospitalization rates were higher for patients with pre-existing psychotic disorders, while patients with affective disorders had lower rates.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Mario Simjanoski, Taiane de Azevedo Cardoso, Bianca Wollenhaupt-Aguiar, Bianca Pfaffenseller, Vicent Balanza-Martinez, Luciano Minuzzi, Flavio Kapczinski
Summary: This study investigated the association between lifestyle behaviors and symptoms of depression and anxiety during the COVID-19 pandemic in Canada. The results showed that unhealthy lifestyle behaviors were associated with depression and anxiety symptoms, emphasizing the importance of lifestyle medicine education and targeted interventions.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2023)
Article
Psychology, Developmental
Isabel Valli, Elena De la Serna, Alex G. Segura, Jose C. Pariente, Angels Calvet-Mirabent, Roger Borras, Daniel Ilzarbe, Dolores Moreno, Nuria Martin-Martinez, Inmaculada Baeza, Mireia Rosa-Justicia, Clemente Garcia-Rizo, Covadonga M. Diaz-Caneja, Nicolas A. Crossley, Allan H. Young, Eduard Vieta, Sergi Mas, Josefina Castro-Fornieles, Gisela Sugranyes
Summary: This study examined cognitive function and its clinical, genetic, and brain imaging correlates in youth at family risk for schizophrenia (SZ) and bipolar disorder (BP). Participants were grouped into intact, intermediate, and impaired clusters based on cognitive performance. The impaired cluster showed lower total brain surface area, particularly in the frontal and temporal cortices, and had poorer psychosocial functioning and worse PRS-COG compared to the other clusters and controls.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Alex G. Segura, Gisela Mezquida, Albert Martinez-Pinteno, Patricia Gasso, Natalia Rodriguez, Lucia Moreno-Izco, Silvia Amoretti, Miquel Bioque, Antonio Lobo, Ana Gonzalez-Pinto, Alicia Garcia-Alcon, Alexandra Roldan-Bejarano, Eduard Vieta, Elena de la Serna, Alba Toll, Manuel J. Cuesta, Sergi Mas, Miquel Bernardo
Summary: Early intervention is crucial for preventing the progression of psychotic disorders. This study found that genetic susceptibility related to cognitive performance is associated with an increased risk of first-episode psychosis (FEP) and its clinical and cognitive progression. Additionally, genetic susceptibility for depression is associated with a worsening trajectory of executive function and general cognitive status.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Leticia Sanguinetti Czepielewski, Marcia Kaurer-Sant Anna, Flavio Kapczinski, Joana Bucker
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Article
Clinical Neurology
Cristina Saiz-Masvidal, Fernando Contreras, Carles Soriano-Mas, Gisela Mezquida, Covadonga M. Diaz-Caneja, Eduard Vieta, Silvia Amoretti, Antonio Lobo, Ana Gonzalez-Pinto, Joost Janssen, Maria Sague-Vilavella, Josefina Castro-Fornieles, Daniel Berge, Miquel Bioque, Noemi G. Lois, Mara Parellada, Miguel Bernardo
Summary: The study investigates the relationship between structural brain alterations and clinical improvement in first-episode psychosis (FEP). Using structural covariance analysis, the researchers found increased correlation in brain regions involved in multisensory signal processing and bodily self-consciousness in the group that showed clinical improvement.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Norma Verdolini, Silvia Alonso-Lana, Pilar Salgado-Pineda, Salvador Sarro, Raymond Salvador, Teresa Maristany, Jose M. Goikolea, Caterina M. Bonnin, Ines Martin, Laura Salo, Ana Romaguera, Elena Rodriguez-Cano, Adriane R. Rosa, Eduard Vieta, Edith Pomarol-Clotet
Summary: This study aimed to assess the brain functional correlates of psychosocial functioning in individuals with bipolar disorder during a working memory task. The results revealed differences in brain activation between bipolar patients and healthy controls, particularly in the medial frontal cortex. In addition, the study found inverse correlations between psychosocial functioning and brain activation in several cortical regions, including the frontal, parietal, and temporo-occipital regions.
PSYCHIATRY RESEARCH
(2023)
Article
Health Care Sciences & Services
Gerard Anmella, Miriam Sanabra, Mireia Prime-Tous, Xavier Segu, Myriam Cavero, Ivette Morilla, Iria Grande, Victoria Ruiz, Ariadna Mas, Ines Martin-Villalba, Alejandro Caballo, Julia-Parisad Esteva, Arturo Rodriguez-Rey, Flavia Piazza, Francisco Jose Valdesoiro, Claudia Rodriguez-Torrella, Marta Espinosa, Giulia Virgili, Carlota Sorroche, Alicia Ruiz, Aleix Solanes, Joaquim Radua, Maria Antonieta Also, Elisenda Sant, Sandra Murgui, Mireia Sans-Corrales, Allan H. Young, Victor Vicens, Jordi Blanch, Elsa Caballeria, Hugo Lopez-Pelayo, Clara Lopez, Victoria Olive, Laura Pujol, Sebastiana Quesada, Brisa Sole, Carla Torrent, Anabel Martinez-Aran, Joana Guarch, Ricard Navines, Andrea Murru, Giovanna Fico, Michele de Prisco, Vicenzo Oliva, Silvia Amoretti, Casimiro Pio-Carrino, Maria Fernandez-Canseco, Marta Villegas, Eduard Vieta, Diego Hidalgo-Mazzei
Summary: This study developed a chatbot named Vickybot, which aimed to screen, monitor, and reduce anxiety-depressive symptoms and work-related burnout, as well as detect suicide risk in primary care and healthcare workers. The feasibility and potential effectiveness of Vickybot were tested in healthy controls and patients, showing that Vickybot was useful in screening and detecting suicide risk, but its effectiveness in reducing anxiety and depressive symptoms was limited.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Gerard Anmella, Filippo Corponi, Bryan M. Li, Ariadna Mas, Miriam Sanabra, Isabella Pacchiarotti, Marc Valenti, Iria Grande, Antoni Benabarre, Anna Gimenez-Palomo, Marina Garriga, Isabel Agasi, Anna Bastidas, Myriam Cavero, Tabatha Fernandez-Plaza, Nestor Arbelo, Miquel Bioque, Clemente Garcia-Rizo, Norma Verdolini, Santiago Madero, Andrea Murru, Silvia Amoretti, Anabel Martinez-Aran, Victoria Ruiz, Giovanna Fico, Michele De Prisco, Vincenzo Oliva, Aleix Solanes, Joaquim Radua, Ludovic Samalin, Allan H. Young, Eduard Vieta, Antonio Vergari, Diego Hidalgo-Mazzei
Summary: This study examined whether physiological wearable data can predict the severity and polarity of affective episodes. The results showed that acceleration, skin temperature, and heart rate were key features for predicting mood disorders. These findings provide a potential pathway for personalized intervention in mental disorders.
JMIR MHEALTH AND UHEALTH
(2023)
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Sourav Khanra, Preethi Reddy, Anna Gimenez-Palomo, Chun Hui J. Park, Bruna Panizzutti, Madeleine McCallum, Shyam Sundar Arumugham, Shreekantiah Umesh, Monojit Debnath, Basudeb Das, Ganesan Venkatasubramanian, Melanie Ashton, Alyna Turner, Olivia M. Dean, Ken Walder, Eduard Vieta, Lakshmi N. Yatham, Isabella Pacchiarotti, Y. C. Janardhan Reddy, Nishant Goyal, Muralidharan Kesavan, Lluc Colomer, Michael Berk, Jee Hyun Kim
Summary: The core feature of bipolar disorder is pathological disturbances in mood, along with disrupted thinking and behavior. Due to its complex and heterogeneous etiology, a range of genetic and environmental factors are involved. This complexity and poorly understood neurobiology make it challenging to develop drugs, resulting in limited treatment options, especially for bipolar depression. Therefore, novel approaches are needed, such as investigating the potential of trimetazidine as a treatment option for bipolar depression.
MOLECULAR PSYCHIATRY
(2023)