Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway

(2014) Torsten Pietsch et al.   ACTA NEUROPATHOLOGICA

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

(2014) S. C. Mack et al.   NATURE

C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

(2014) Matthew Parker et al.   NATURE

Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

(2014) D. Meco et al.   NEURO-ONCOLOGY

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

(2013) Marc Remke et al.   ACTA NEUROPATHOLOGICA

PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival

(2013) H. A. Rogers et al.   CLINICAL CANCER RESEARCH

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

(2013) Pedro Castelo-Branco et al.   LANCET ONCOLOGY

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas

(2013) Malak Abedalthagafi et al.   MODERN PATHOLOGY

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

A prognostic gene expression signature in infratentorial ependymoma

(2012) Khalida Wani et al.   ACTA NEUROPATHOLOGICA

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Prognostic factors and treatment options for paediatric ependymomas

(2012) K. Vaidya et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Predictors of outcome in an AIEOP series of childhood ependymomas: a multifactorial analysis

(2012) Piergiorgio Modena et al.   NEURO-ONCOLOGY

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

(2011) Till Milde et al.   ACTA NEUROPATHOLOGICA

Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance and Can be Safely Targeted for Telomerase Inhibition

(2011) P. Castelo-Branco et al.   CLINICAL CANCER RESEARCH

Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer

(2011) Diego Serrano et al.   Molecular Cancer

Telomerase Inhibition as a Novel Therapy for Pediatric Ependymoma

(2010) Vincent C.H. Wong et al.   BRAIN PATHOLOGY

The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth

(2010) C. O. Marian et al.   CLINICAL CANCER RESEARCH

Molecular Staging of Intracranial Ependymoma in Children and Adults

(2010) Andrey Korshunov et al.   JOURNAL OF CLINICAL ONCOLOGY

Cross-species genomics matches driver mutations and cell compartments to model ependymoma

(2010) Robert A. Johnson et al.   NATURE

A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo

(2010) L. Yu et al.   NEURO-ONCOLOGY

Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms

(2010) Sarah K. Brennan et al.   PLoS One

The history of ependymoma management

(2009) Kyu-Won Shim et al.   CHILDS NERVOUS SYSTEM

Ependymoma: An Update

(2009) Stergios Zacharoulis et al.   JOURNAL OF CHILD NEUROLOGY

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas

(2008) Vincent C.H. Wong et al.   CANCER LETTERS

Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma

(2008) Lee Ridley et al.   NEURO-ONCOLOGY