Anti-Aβ antibody target engagement: a response to Siemers et al.

Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?

(2014) Andrew D. Watt et al.   ACTA NEUROPATHOLOGICA

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

(2014) Hadar Feinberg et al.   Alzheimers Research & Therapy

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

(2013) Andrew D. Watt et al.   ACTA NEUROPATHOLOGICA

Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer’s Disease Neuroimaging Initiative study patients

(2012) Michal J. Figurski et al.   Alzheimers & Dementia

Small Amphipathic Molecules Modulate Secondary Structure and Amyloid Fibril-forming Kinetics of Alzheimer Disease Peptide Aβ1–42

(2012) Timothy M. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Blood-Borne Amyloid-  Dimer Correlates with Clinical Markers of Alzheimer's Disease

(2010) V. L. Villemagne et al.   JOURNAL OF NEUROSCIENCE

Structures of Aβ-Related Peptide−Monoclonal Antibody Complexes,

(2009) Anna Gardberg et al.   BIOCHEMISTRY

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

The epitope space of the human proteome

(2008) Lisa Berglund et al.   PROTEIN SCIENCE

Qualitative and quantitative characterization of the amyloid β peptide (Aβ) population in biological matrices using an immunoprecipitation–LC/MS assay

(2007) Michael J. Ford et al.   JOURNAL OF NEUROSCIENCE METHODS

Urea modulation of β-amyloid fibril growth: Experimental studies and kinetic models

(2004) Jin Ryoun Kim et al.   PROTEIN SCIENCE