The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

(2015) Alexandra Borodovsky et al.   Oncotarget

Mutant IDH1-Driven Cellular Transformation Increases RAD51-Mediated Homologous Recombination and Temozolomide Resistance

(2014) Shigeo Ohba et al.   CANCER RESEARCH

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Expression and Regulation of Prostate Apoptosis Response-4 (Par-4) in Human Glioma Stem Cells in Drug-Induced Apoptosis

(2014) Jayashree C. Jagtap et al.   PLoS One

What do we know about IDH1/2 mutations so far, and how do we use it?

(2013) Craig Horbinski   ACTA NEUROPATHOLOGICA

Autophagy and oxidative stress in gliomas with IDH1 mutations

(2013) Misty R. Gilbert et al.   ACTA NEUROPATHOLOGICA

Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy

(2013) James V. Alvarez et al.   CANCER CELL

IDH1 and IDH2 Mutations in Gliomas

(2013) Adam L. Cohen et al.   Current Neurology and Neuroscience Reports

Induction of sarcomas by mutant IDH2

(2013) C. Lu et al.   GENES & DEVELOPMENT

BCAT1 defines gliomas by IDH status

(2013) Jared R Mayers et al.   NATURE MEDICINE

Lactate dehydrogenase A silencing in IDH mutant gliomas

(2013) Charles Chesnelong et al.   NEURO-ONCOLOGY

Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells

(2013) C Lu et al.   ONCOGENE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Expression of PAR-4 and PHLDA1 is prognostic for overall and disease-free survival in oral squamous cell carcinomas

(2013) Cláudia Malheiros Coutinho-Camillo et al.   VIRCHOWS ARCHIV

Identification of Retinol Binding Protein 1 Promoter Hypermethylation in Isocitrate Dehydrogenase 1 and 2 Mutant Gliomas

(2012) Arthur P. Chou et al.   JNCI-Journal of the National Cancer Institute

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation

(2012) Sichen Li et al.   NEURO-ONCOLOGY

Systemic Par-4 inhibits non-autochthonous tumor growth

(2011) Yanming Zhao et al.   CANCER BIOLOGY & THERAPY

The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model

(2011) A. K. Sharma et al.   CLINICAL CANCER RESEARCH

TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells

(2011) Dongxiao Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

(2010) J. Wei et al.   CLINICAL CANCER RESEARCH

PAR-4 as a possible new target for pancreatic cancer therapy

(2010) Asfar S Azmi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer

(2010) Nagai   INTERNATIONAL JOURNAL OF ONCOLOGY

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Cancer-selective apoptotic effects of extracellular and intracellular Par-4

(2010) T Shrestha-Bhattarai et al.   ONCOGENE

Cancer Stem Cells: The Final Frontier for Glioma Virotherapy

(2010) Mahua Dey et al.   Stem Cell Reviews and Reports

Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation

(2009) David Capper et al.   ACTA NEUROPATHOLOGICA

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis

(2009) Ravshan Burikhanov et al.   CELL

Transcriptional regulation of pro-apoptotic Par-4 by NF-κB/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis

(2009) Makoto Saegusa et al.   JOURNAL OF PATHOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF- B activation and invasive prostate carcinoma

(2009) P. J. Fernandez-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Par-4 Binds to Topoisomerase 1 and Attenuates Its DNA Relaxation Activity

(2008) A. Goswami et al.   CANCER RESEARCH

Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis

(2008) Jayashree Joshi et al.   EMBO JOURNAL

Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells

(2007) Tae-Jin Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY