Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors
Authors
Keywords
Giant Cell Tumor, Pediatric Brain Tumor, Diffuse Intrinsic Pontine Glioma, TERT Promoter Mutation, K27M Mutation
Journal
ACTA NEUROPATHOLOGICA
Volume 128, Issue 5, Pages 615-627
Publisher
Springer Nature
Online
2014-07-30
DOI
10.1007/s00401-014-1325-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
- (2015) Yuchen Jiao et al. Oncotarget
- Childhood and adolescent cancer statistics, 2014
- (2014) Elizabeth Ward et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
- (2014) S. C. Mack et al. NATURE
- The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
- (2014) Gang Wu et al. NATURE GENETICS
- Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
- (2014) Pawel Buczkowicz et al. NATURE GENETICS
- Identification of functional cooperative mutations of SETD2 in human acute leukemia
- (2014) Xiaofan Zhu et al. NATURE GENETICS
- Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
- (2014) Kathryn R Taylor et al. NATURE GENETICS
- Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
- (2014) Adam M Fontebasso et al. NATURE GENETICS
- Every amino acid matters: essential contributions of histone variants to mammalian development and disease
- (2014) Ian Maze et al. NATURE REVIEWS GENETICS
- Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes
- (2013) Amanda M. Saratsis et al. ACTA NEUROPATHOLOGICA
- Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma
- (2013) Sally R. Lambert et al. ACTA NEUROPATHOLOGICA
- Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
- (2013) Adam M. Fontebasso et al. ACTA NEUROPATHOLOGICA
- DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
- (2013) Edward C. Schwalbe et al. ACTA NEUROPATHOLOGICA
- Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays
- (2013) Volker Hovestadt et al. ACTA NEUROPATHOLOGICA
- Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
- (2013) Andrey Korshunov et al. ACTA NEUROPATHOLOGICA
- Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 inH3F3AK27M Mutant Glioblastomas
- (2013) Sriram Venneti et al. BRAIN PATHOLOGY
- Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
- (2013) Sebastian Bender et al. CANCER CELL
- The Somatic Genomic Landscape of Glioblastoma
- (2013) Cameron W. Brennan et al. CELL
- The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
- (2013) K.-M. Chan et al. GENES & DEVELOPMENT
- ConditionalKIAA1549:BRAFmice reveal brain region- and cell type-specific effects
- (2013) Aparna Kaul et al. GENESIS
- Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
- (2013) Sam Behjati et al. NATURE GENETICS
- Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
- (2013) David T W Jones et al. NATURE GENETICS
- Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
- (2013) Claudia L Kleinman et al. NATURE GENETICS
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
- (2013) B. E. Johnson et al. SCIENCE
- Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
- (2013) Lynn Bjerke et al. Cancer Discovery
- Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
- (2012) Adrian M. Dubuc et al. ACTA NEUROPATHOLOGICA
- Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
- (2012) Xiao-Yang Liu et al. ACTA NEUROPATHOLOGICA
- K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
- (2012) Dong-Anh Khuong-Quang et al. ACTA NEUROPATHOLOGICA
- Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
- (2012) Dominik Sturm et al. CANCER CELL
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Novel mutations target distinct subgroups of medulloblastoma
- (2012) Giles Robinson et al. NATURE
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
- (2012) Gang Wu et al. NATURE GENETICS
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice
- (2012) D. Friedmann-Morvinski et al. SCIENCE
- Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
- (2011) Huriye Cin et al. ACTA NEUROPATHOLOGICA
- Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
- (2011) Paul A. Northcott et al. ACTA NEUROPATHOLOGICA
- Genetic profile of astrocytic and oligodendroglial gliomas
- (2011) Hiroko Ohgaki et al. Brain Tumor Pathology
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- MAPK pathway activation in pilocytic astrocytoma
- (2011) David T. W. Jones et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma
- (2011) C. Hawkins et al. CLINICAL CANCER RESEARCH
- Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
- (2011) K. Jacob et al. CLINICAL CANCER RESEARCH
- The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9
- (2011) Arunkumar Dhayalan et al. HUMAN MOLECULAR GENETICS
- Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma
- (2011) Barbara S. Paugh et al. JOURNAL OF CLINICAL ONCOLOGY
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
- (2011) Ignacio Varela et al. NATURE
- Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas
- (2011) Hui-Qi Qu et al. NEURO-ONCOLOGY
- Altered Telomeres in Tumors with ATRX and DAXX Mutations
- (2011) C. M. Heaphy et al. SCIENCE
- Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma
- (2010) Hani Al-Halabi et al. ACTA NEUROPATHOLOGICA
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
- (2010) Houtan Noushmehr et al. CANCER CELL
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma
- (2010) O. J. Becher et al. CANCER RESEARCH
- Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
- (2010) Aaron D. Goldberg et al. CELL
- IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group
- (2010) Ian F. Pollack et al. CHILDS NERVOUS SYSTEM
- Brain Tumors: From Childhood Through Adolescence Into Adulthood
- (2010) Mark W. Kieran et al. JOURNAL OF CLINICAL ONCOLOGY
- Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets
- (2010) Maryam Zarghooni et al. JOURNAL OF CLINICAL ONCOLOGY
- Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease
- (2010) Barbara S. Paugh et al. JOURNAL OF CLINICAL ONCOLOGY
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- (2010) Gillian L. Dalgliesh et al. NATURE
- Update on molecular findings, management and outcome in low-grade gliomas
- (2010) T. David Bourne et al. Nature Reviews Neurology
- Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
- (2010) P. W. Lewis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
- (2009) K Jacob et al. BRITISH JOURNAL OF CANCER
- A Network Model of a Cooperative Genetic Landscape in Brain Tumors
- (2009) Markus Bredel et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network
- (2009) Michael Weller et al. JOURNAL OF CLINICAL ONCOLOGY
- Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase
- (2009) Y. Gao et al. MOLECULAR CANCER THERAPEUTICS
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
- (2009) Paul A Northcott et al. NATURE GENETICS
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pediatric glioblastoma cell line shows different patterns of expression of transmembrane ABC transporters after in vitro exposure to vinblastine
- (2008) Elvis Terci Valera et al. CHILDS NERVOUS SYSTEM
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started