Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response

Intrinsic and Induced Regulation of the Age-Associated Onset of Spontaneous Experimental Autoimmune Encephalomyelitis

(2014) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis

(2014) G. C. Furtado et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2014) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial

(2013) Ralf Gold et al.   LANCET

Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response

(2012) Stefanie Kuerten et al.   ACTA NEUROPATHOLOGICA

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation

(2012) Peter J. Darlington et al.   ANNALS OF NEUROLOGY

Alemtuzumab more effective than interferon  -1a at 5-year follow-up of CAMMS223 Clinical Trial

(2012) A. J. Coles et al.   NEUROLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Genetic proof for the transient nature of the Th17 phenotype

(2010) Florian C. Kurschus et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Precarious Balance: Th17 Cells in Host Defense

(2009) A. Peck et al.   INFECTION AND IMMUNITY

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: In Vitro Generated Th17 Cells Maintain Their Cytokine Expression Program in Normal but Not Lymphopenic Hosts

(2009) R. Nurieva et al.   JOURNAL OF IMMUNOLOGY

Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles

(2009) Sara Abromson-Leeman et al.   JOURNAL OF NEUROIMMUNOLOGY

Mixed results with modulation of TH-17 cells in human autoimmune diseases

(2009) Lawrence Steinman   NATURE IMMUNOLOGY

Interferon Beta–Induced Restoration of Regulatory T-Cell Function in Multiple Sclerosis Is Prompted by an Increase in Newly Generated Naive Regulatory T Cells

(2008) Mirjam Korporal et al.   ARCHIVES OF NEUROLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

How interferon-γ keeps autoimmune diseases in check

(2008) Hilde Kelchtermans et al.   TRENDS IN IMMUNOLOGY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY