Review
Behavioral Sciences
Sijia Zhao, Sofia Toniolo, Adam Hampshire, Masud Husain
Summary: COVID-19 is associated with a range of neurological, cognitive, and mental health symptoms that can persist for many months after infection in people with long-COVID syndrome. Investigations have revealed that these symptoms may be related to brain imaging abnormalities, but can also occur in the absence of objective cognitive deficits or neuroimaging changes. Furthermore, cognitive impairment may even be detected in asymptomatic individuals.
TRENDS IN COGNITIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Guilherme Dias de Melo, Victoire Perraud, Flavio Alvarez, Alba Vieites-Prado, Seonhee Kim, Lauriane Kergoat, Anthony Coleon, Bettina Salome Trueb, Magali Tichit, Aurele Piazza, Agnes Thierry, David Hardy, Nicolas Wolff, Sandie Munier, Romain Koszul, Etienne Simon-Loriere, Volker Thiel, Marc Lecuit, Pierre-Marie Lledo, Nicolas Renier, Florence Larrous, Herve Bourhy
Summary: This study assesses the clinical, olfactory, and neuroinflammatory conditions of golden hamsters infected with SARS-CoV-2 wt and VOCs and finds that the viruses can infect neurons, travel inside axons, and invade the central nervous system. Anosmia, which was previously identified as a hallmark of COVID-19, has become less frequent with the emergence of variants of concern.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Guilherme Dias de Melo, Victoire Perraud, Flavio Alvarez, Alba Vieites-Prado, Seonhee Kim, Lauriane Kergoat, Anthony Coleon, Bettina Salome Trueeb, Magali Tichit, Aurele Piazza, Agnes Thierry, David Hardy, Nicolas Wolff, Sandie Munier, Romain Koszul, Etienne Simon-Loriere, Volker Thiel, Marc Lecuit, Pierre-Marie Lledo, Nicolas Renier, Florence Larrous, Herve Bourhy
Summary: Researchers assessed the clinical, olfactory, and neuroinflammatory conditions of golden hamsters infected with SARS-CoV-2 and its variants, finding that infected animals developed variant-dependent clinical diseases, including anosmia, and that the ORF7 gene of SARS-CoV-2 contributed to the induction of olfactory dysfunction. In addition, all SARS-CoV-2 variants were able to invade the nervous system, regardless of the clinical presentation they induced. This confirms that neuroinvasion and anosmia are independent phenomena upon SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2023)
Article
Physics, Fluids & Plasmas
Carlo Baldassi, Clarissa Lauditi, Enrico M. Malatesta, Rosalba Pacelli, Gabriele Perugini, Riccardo Zecchina
Summary: Current deep neural networks, despite being overparameterized and nonlinear, can fit data perfectly and achieve high prediction accuracy. This paper uses methods from statistical physics to study the computational impact of overparameterization on nonconvex neural network models and explores the relationship between learning and generalization performance.
Article
Chemistry, Inorganic & Nuclear
Michael Wells, Jacob Hempel, Santosh Adhikari, Qingping Wang, Daniel Allen, Alison Costello, Chris Bowen, Sean Parkin, Christopher Sutton, Aron J. Huckaba
Summary: In this study, a series of organic-inorganic hybrid metallates are reported, and their crystal structures and responsiveness are studied using X-ray crystallography and piezoresponse force microscopy. Density functional theory calculations reveal that one of the compounds (HistNH3ZnCl4) exhibits higher response values due to lower hybridization.
INORGANIC CHEMISTRY
(2022)
Editorial Material
Neurosciences
Aasef G. Shaikh, Mario Manto, Hiroshi Mitoma
Summary: The COVID-19 pandemic has had significant effects on the cerebellar system, both directly through viral invasion and indirectly through immune, hematological, and metabolic pathways.
Article
Biochemistry & Molecular Biology
Oriana Mandolfo, Helen Parker, Brian Bigger
Summary: Mucopolysaccharidoses are rare pediatric lysosomal storage disorders characterized by the accumulation of glycosaminoglycans. Inflammation plays a crucial role in disease progression, and current treatments face challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Johnathan Cooper-Knock, Thomas H. Julian, Emily Feneberg, J. Robin Highley, Maurice Sidra, Martin R. Turner, Kevin Talbot, Olaf Ansorge, Scott P. Allen, Tobias Moll, Tatyana Shelkovnikova, Lydia Castelli, Guillaume M. Hautbergue, Christopher Hewitt, Janine Kirby, Stephen B. Wharton, Richard J. Mead, Pamela J. Shaw
Summary: We describe a multi-generational pedigree of amyotrophic lateral sclerosis (ALS) with an autosomal dominant, fully penetrant mutation in the TDP-43 gene. The hallmark pathology of ALS is the mislocalization of TDP-43 and the formation of insoluble TDP-43-positive neuronal cytoplasmic inclusions. While the lower motor neurons showed typical TDP-43 pathology, the motor cortex did not show classical TDP-43-positive inclusions. Despite reduced overall TDP-43 protein expression, the mutated allele was transcribed and translated in patient fibroblasts and motor cortex tissue. Furthermore, the motor cortex tissue carrying the mutation showed atypical TDP-43 protein species but not typical C-terminal fragments. Our findings suggest that the p.Y374X mutation is responsible for a monogenic, fully penetrant form of ALS and expands the molecular phenotypes associated with TDP-43 mutations and ALS.
Article
Clinical Neurology
Kamalini G. Ranasinghe, Cathrine Petersen, Kiwamu Kudo, Danielle Mizuiri, Katherine P. Rankin, Gil D. Rabinovici, Maria Luisa Gorno-Tempini, William W. Seeley, Salvatore Spina, Bruce L. Miller, Keith Vossel, Lea T. Grinberg, Srikantan S. Nagarajan
Summary: Reduced alpha synchrony is a sensitive neurophysiological index associated with pathological tau, and a potential network biomarker for clinical trials targeting tau pathways in AD.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Walid Khrouf, Dario Saracino, Benoit Rucheton, Marion Houot, Fabienne Clot, Daisy Rinaldi, Joana Vitor, Marie Huynh, Evelyne Heng, Dimitri Schlemmer, Florence Pasquier, Vincent Deramecourt, Sophie Auriacombe, Carole Azuar, Richard Levy, Stephanie Bombois, Claire Boutoleau-Bretonniere, Jeremie Pariente, Mira Didic, David Wallon, Frederique Fluchere, Stephane Auvin, Imen Ben Younes, Yann Nadjar, Alexis Brice, Bruno Dubois, Dominique Bonnefont-Rousselot, Isabelle Le Ber, Foudil Lamari
Summary: GRN mutations lead to increased plasma levels of lysosphingolipids (lysoSPL) in individuals with frontotemporal dementia (FTD). Among FTD patients, lysoSPL levels are specifically elevated in GRN carriers. LGL1 levels are associated with neurofilament increases in presymptomatic carriers.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Qiongling Li, Shahin Tavakol, Jessica Royer, Sara Lariviere, Reinder Vos De Wael, Bo-yong Park, Casey Paquola, Debin Zeng, Benoitu Caldairou, Danielle S. Bassett, Andrea Bernasconi, Neda Bernasconi, Birgit Frauscher, Jonathan Smallwood, Lorenzo Caciagli, Shuyu Li, Boris C. Bernhardt
Summary: This study suggests that a lack of pattern separation may lead to weakened episodic memory. In healthy participants, there is a gradient relationship between neural activity and pattern separation, while patients with temporal lobe epilepsy show a reduced concordance in this relationship. Connectivity gradients are closely associated with cognitive processes.
Article
Computer Science, Artificial Intelligence
Mohammed Ibrahim Al-Twijri, Jose Maria Luna, Francisco Herrera, Sebastian Ventura
Summary: Providing a good study plan is crucial for avoiding student failure. Academic advising based on student preferences and background knowledge is effective in reducing dropout rates. This article proposes a course recommendation method that uses the sequence of courses taken by each student to recommend courses. Unlike existing methods, this approach is based on graduate students' course modeling and avoids bias introduced by external factors. The proposed method includes a novel sequential pattern mining algorithm that identifies paths followed by successful students and not followed by less successful students. A real study case involving over 13,000 students from 13 faculties is used to demonstrate the usefulness of the proposal in recommending study plans and providing advice at different stages of the learning process.
COGNITIVE COMPUTATION
(2022)
Article
Multidisciplinary Sciences
Michail Spanos, Sigal Shachar, Thadryan Sweeney, Immo Lehmann, Priyanka Gokulnath, Guoping Li, George B. Sigal, Rajini Nagaraj, Pradeepthi Bathala, Farhan Rana, Ravi V. Shah, David A. Routenberg, Saumya Das
Summary: Patients hospitalized with SARS-CoV-2 infection have a higher risk of developing long-term neurological symptoms after recovery. Age, disease severity, and the infection itself are associated with additional risk for neurological sequelae. Glial fibrillary astrocytic protein (GFAP) and neurofilament light chain (NF-L) may serve as potential biomarkers for long-term neurologic complications after SARS-CoV-2 infection.
Article
Mathematics, Interdisciplinary Applications
Mozhgan Mokhtari, Majid Vaziri Sarashk, Milad Asadpour, Nadia Saeidi, Omid Boyer
Summary: In recent years, timetable programming in academic settings has become increasingly challenging due to various factors. Researchers have been exploring different methods to address the problem of timetabling lectures. A multiobjective mixed-integer programming model was developed to provide an efficient timetable for university lectures, minimizing violations and optimizing student travel time.
Article
Oncology
Alexander D. Rebchuk, Bradley M. Chaharyn, Armaghan Alam, Celine D. Hounjet, Peter A. Gooderham, Stephen Yip, Serge Makarenko
Summary: This study compared the incidence and distribution of meningiomas under the 2007 and 2016 WHO criteria and found that adding brain invasion as a diagnostic criterion for Grade 2 meningiomas had minimal impact on the incidence of specific tumor grades. There was strong agreement between the 2007 and 2016 WHO criteria.
Article
Genetics & Heredity
Filip Majer, Bohdan Kousal, Petr Dusek, Lenka Piherova, Martin Reboun, Romana Mihalova, Jiri Gurka, Alice Krebsova, Hana Vlaskova, Lenka Dvorakova, Jana Krihova, Petra Liskova, Stanislav Kmoch, Tomas Kalina, Milos Kubanek, Jakub Sikora
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2020)
Article
Neurosciences
Anna Mikulecka, Rastislav Druga, Ales Stuchlik, Pavel Mares, Hana Kubova
EXPERIMENTAL NEUROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ivana Jedlickova, Maxime Cadieux-Dion, Anna Pristoupilova, Viktor Stranecky, Hana Hartmannova, Katerina Hodanova, Veronika Baresova, Helena Hulkova, Jakub Sikora, Lenka Noskova, Dita Musalkova, Petr Vyletal, Jana Sovova, Patrick Cossette, Eva Andermann, Frederick Andermann, Stanislav Kmoch
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Genetics & Heredity
Dita Musalkova, Filip Majer, Ladislav Kuchar, Ondrej Luksan, Befekadu Asfaw, Hana Vlaskova, Gabriela Storkanova, Martin Reboun, Helena Poupetova, Helena Jahnova, Helena Hulkova, Jana Ledvinova, Lenka Dvorakova, Jakub Sikora, Milan Jirsa, Marie T. Vanier, Martin Hrebicek
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Article
Genetics & Heredity
Insun Park, Helena Hulkova, Jakub Krijt, Viktor Kozich, Erez M. Bublil, Tomas Majtan
Letter
Pediatrics
Marketa Tesarova, Viktor Stranecky, Petra Konecna, Dagmar Prochazkova, Helena Hulkova, Jiri Zeman, Tomas Honzik, Martin Magner
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Ivana Jedlickova, Anna Pristoupilova, Helena Hulkova, Alena Vrbacka, Viktor Stranecky, Eva Hruba, Pavel Jesina, Tomas Honzik, Ivan Hrdlicka, Jiri Fremuth, Kristyna Pivovarcikova, Ibrahim Bitar, Radoslav Matej, Stanislav Kmoch, Jakub Sikora
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Josef Marek, Petr Kuchynka, Vladimir Mikulenka, Tomas Palecek, Jakub Sikora, Helena Hulkova, Lukas Lambert, Hana Linkova, David Zemanek, Marketa Tesarova, Ales Linhart, Jiri Zeman, Martin Magner
Summary: MPS VII is a rare lysosomal storage disorder caused by mutations in the GUSB gene. Patients often present with cardiac and valvular impairment. Surgical intervention can lead to significant improvement in clinical symptoms.
CARDIOVASCULAR PATHOLOGY
(2021)
Letter
Clinical Neurology
Jiri Taborsky, Radoslav Matej, Hana Vlaskova, Jiri Keller, Silvie Johanidesova, Robert Rusina
NEUROLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Bohdan Kousal, Lucia Hlavata, Hana Vlaskova, Lenka Dvorakova, Michaela Brichova, Zora Dubska, Hana Langrova, Andrea L. Vincent, Lubica Dudakova, Petra Liskova
Summary: This study aimed to identify RS1 pathogenic variants in Czech patients with XLRS. Twelve disease-causing variants within RS1 were identified, including five novel variants. Some patients were misdiagnosed as having intermediate uveitis.
Article
Physiology
Martin Salaj, Filip Barinka, Hana Kubova, Rastislav Druga
Summary: The study aimed to describe the interneuronal population expressing calcium binding proteins calretinin (CR) and parvalbumin (PV) in the perirhinal (PRC) and retrosplenial (RSC) cortex of rats. The results showed that PRC has higher absolute and relative densities of CR+ and PV+ neurons compared to RSC, with a higher CR:PV ratio in RSC similar to the neocortex.
PHYSIOLOGICAL RESEARCH
(2021)
Meeting Abstract
Transplantation
Martina Zivna, Petr Vylet'al, Veronika Baresova, Katerina Hodanova, Viktor Stranecky, Hana Hartmannova, Helena Hulkova, Ivana Jedlickova, Jana Sovova, Kendrah Kidd, Anthony J. Bleyer, Stanislav Kmoch
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
P. Chrastina, H. Vlaskova, L. Dvorakova, S. Fingerhutova, E. Jancova, P. Keslova, A. Klocperk, M. Schuller, A. Kolsky, K. Peskova, P. Dolezalova
EUROPEAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Endocrinology & Metabolism
Marketa Zemanova, Petr Chrastina, Lenka Dvorakova, Martin Reboun, Hana Vlaskova, Helena Jahnova, Nabil El-Lababidi, Jana Cepova, Tomas Honzik, Jiri Zeman
Summary: This retrospective study focused on 45 hemizygous males and 50 heterozygous females with X-ALD from 35 unrelated families. Various ABCD1 gene mutations were identified, but no correlation was found between disease severity and genotype, scores, protein abnormalities, or X-inactivation. VLCFA levels were higher in males compared to heterozygous females, and decreased during Lorenzo's and GTO oils diet.
NEUROENDOCRINOLOGY LETTERS
(2021)