Article
Cell Biology
Zhi-Ren Tsai, Han-Wei Zhang, Chun-Hung Tseng, Hsiao-Ching Peng, Victor C. Kok, Gao Ping Li, Chao A. Hsiung, Chun-Yi Hsu
Summary: A retrospective cohort study conducted in Taiwan showed that individuals with epilepsy are at a significantly increased risk of developing dementia, especially those aged 50 years and above.
Article
Clinical Neurology
Tobey J. Betthauser, Murat Bilgel, Rebecca L. Koscik, Bruno M. Jedynak, Yang An, Kristina A. Kellett, Abhay Moghekar, Erin M. Jonaitis, Charles K. Stone, Corinne D. Engelman, Sanjay Asthana, Bradley T. Christian, Dean F. Wong, Marilyn Albert, Susan M. Resnick, Sterling C. Johnson
Summary: Alzheimer's disease biomarkers are crucial for understanding disease progression and predicting symptoms. This study develops and evaluates methods for modeling amyloid accumulation and investigates factors influencing the timing of amyloid onset and impairment onset. The findings suggest that APOE genotype, rather than sex, is associated with amyloid onset age, and that higher APOEe4 dosage, being female, and older amyloid onset age shorten the time from amyloid onset to dementia.
Article
Geriatrics & Gerontology
Samantha M. Loi, Paraskevi Tsoukra, Emily Sun, Zhibin Chen, Pierre Wibawa, Maria di Biase, Sarah Farrand, Dhamidhu Eratne, Wendy Kelso, Andrew Evans, Mark Walterfang, Dennis Velakoulis
Summary: This study compares survival rates and risk factors associated with mortality in common young-onset dementias, including Huntington's disease. It found that individuals with young-onset dementia have a significantly higher mortality rate compared to the general population. Huntington's disease patients have the longest survival time and a lower mortality risk.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Percy Griffin, Liana Apostolova, Bradford C. Dickerson, Gil Rabinovici, Stephen Salloway, Katie Brandt, Joseph Masdeu, Dustin Hammers, Srilatha Raghuram, Stephen Hall, Maria C. Carrillo
Summary: The Alzheimer's Association hosted a meeting focusing on individuals with early-onset Alzheimer's disease (EOAD) or younger onset Alzheimer's disease (AD) on September 25 and 26, 2021. This meeting aimed to provide information on the latest research, treatments, legal and financial considerations, and support networks for individuals with EOAD and their families. The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) was also introduced as a research project to enroll and follow 500 people with EOAD from various sites in the United States.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Gargi Banerjee, John Collinge, Nick C. Fox, Tammaryn Lashley, Simon Mead, Jonathan M. Schott, David J. Werring, Natalie S. Ryan
Summary: Cerebral amyloid angiopathy (CAA) is a significant cerebral small vessel disease that is associated with brain haemorrhage and cognitive change. While the common form affects individuals in mid- to later life, rare early-onset forms are increasingly recognized and may be caused by genetic or iatrogenic factors. This review provides an overview of the causes of early-onset CAA and proposes a structured approach for investigation and management, aiming to raise awareness among healthcare professionals.
Article
Clinical Neurology
Kangli Fan, Hongguang Zhao, Yinghua Li, Xiaoxiao Du, Yuyin Dai, Lulu Gao, Yi Li, Zhihui Sun, Ying Zhang
Summary: This study aims to explore the difference between C-11-CFT PET imaging in early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD), and analyze its correlation with disease duration, H & Y stage, motor symptoms, and non-motor symptoms, in order to evaluate its value in assessing disease severity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Imke Seifert, Henrik Wiegelmann, Marta Lenart-Bugla, Mateusz Luc, Marcin Pawlowski, Etienne Rouwette, Joanna Rymaszewska, Dorota Szczesniak, Myrra Vernooij-Dassen, Marieke Perry, Rene Melis, Karin Wolf-Ostermann, Ansgar Gerhardus
Summary: Dementia is a multi-factorial condition. This study developed a causal loop diagram with 73 factors across six domains through a systematic literature review and expert discussions, offering a comprehensive visualization of factors related to cognitive decline and their interactions for generating hypotheses on causal relationships.
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sarah Haoudy, Therese Jonveaux, Salome Puisieux, Jonathan Epstein, Lucie Hopes, Louis Maillard, Olivier Aron, Louise Tyvaert
Summary: This study investigated the occurrence of epilepsy in patients with early onset Alzheimer's disease (EOAD). The findings showed that 40% of the patients had epilepsy, which may contribute to accelerated cognitive decline and be associated with a severe form of EOAD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychiatry
Manuela Tondelli, Chiara Galli, Giulia Vinceti, Luigi Fiondella, Simone Salemme, Chiara Carbone, Maria Angela Molinari, Annalisa Chiari, Giovanna Zamboni
Summary: Anosognosia levels were not significantly different between early-onset dementia (EOD) and late-onset dementia (LOD) patients, but increased with disease progression, especially in frontotemporal dementia cases. Early anosognosia was associated with higher frequency and severity of subsequent neuropsychiatric symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Jingwei Sim, Huihua Li, Shahul Hameed, Simon Kang Seng Ting
Summary: This study found that early-onset DLB has clinical features that distinguish it from early-onset AD, whereas features of late-onset DLB are associated with a higher burden of AD copathology.
Article
Geriatrics & Gerontology
Samuli Huttula, Henri Vayrynen, Seppo Helisalmi, Laura Kytovuori, Laura Luukkainen, Mikko Hiltunen, Anne M. Remes, Johanna Kruger
Summary: Early-onset dementia (EOD) has a strong genetic component. This study identified a variant in the NDUFA1 gene that may be associated with neurodegenerative dementia in EOD patients.
NEUROBIOLOGY OF AGING
(2022)
Article
Multidisciplinary Sciences
Barbara Yael Braz, Doris Wennagel, Leslie Ratie, Diego Alves Rodrigues de Souza, Jean Christophe Deloulme, Emmanuel L. Barbier, Alain Buisson, Fabien Lante, Sandrine Humbert
Summary: Recent evidence suggests that mild mutations in the Huntingtin gene associated with late-onset Huntington's disease disrupt human neurodevelopment. This study found that newborn HD mice exhibit early neural circuit deficits, but these deficits can be rescued by pharmacologically enhancing glutamatergic transmission during the neonatal period.
Article
Clinical Neurology
Ying Zhang, Junyi Zhou, Carissa R. Gehl, Jeffrey D. Long, Hans Johnson, Vincent A. Magnotta, Daniel Sewell, Kathleen Shannon, Jane S. Paulsen
Summary: This study found that Mild Cognitive Impairment (MCI) may serve as an indicator of early disease in Huntington's disease gene-mutation carriers; single-domain MCI, two-domain MCI, and dementia may represent appropriate cognitive impairment staging.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Annalisa Chiari, Giulia Vinceti, Giorgia Adani, Manuela Tondelli, Chiara Galli, Luigi Fiondella, Manuela Costa, Maria A. Molinari, Tommaso Filippini, Giovanna Zamboni, Marco Vinceti
Summary: Research investigated the epidemiology of EOD by identifying patients in the extended network of dementia services in Modena province, Northern Italy. The incidence of EOD in the 30-64 age group was 13.2 per 100,000/year, with a prevalence of 74.3 per 100,000 on June 30, 2019. The most common phenotypes were the amnestic variant of AD and the behavioral variant of FTD.
ALZHEIMERS & DEMENTIA
(2021)
