Article
Biochemistry & Molecular Biology
Bastian Weiss, Alexander Pichler, Anna Damulina, Arabella Buchmann, Sonja Hochmeister, Thomas Seifert-Held, Christian Enzinger, Juan-Jose Archelos, Michael Khalil
Summary: This study evaluated the clinical significance of quantitative kappa free light chains (k-FLC) in patients with an isolated band in the cerebrospinal fluid (CSF). The results showed that positive k-FLC can indicate the possibility of neuroinflammatory diseases in patients with an isolated band in isoelectric focusing (IEF). Therefore, measuring k-FLC can provide support in the diagnosis of neurological diseases.
Article
Pharmacology & Pharmacy
Sumanta Kumar Goswami, Prabhat Ranjan, Roshan Kumar Dutta, Suresh Kumar Verma
Summary: Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with inflammation playing a key role in its development. Immune cells and cytokines are crucial in regulating cardiac inflammation, with IL-10 playing a significant role in reducing cardiovascular inflammation and protecting the cardiovascular system.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Enric Monreal, Susana Sainz de la Maza, Lucienne Costa-Frossard, Paulette Walo-Delgado, Javier Zamora, Jose Ignacio Fernandez-Velasco, Noelia Villarrubia, Mercedes Espino, Daniel Lourido, Paloma Lapuente, Inmaculada Toboso, Jose Carlos Alvarez-Cermeno, Jaime Masjuan, Luisa Maria Villar
Summary: The study suggests that measuring lipid-specific IgM oligoclonal bands can predict disease progression in MS patients, especially those with CIS, over a follow-up of at least 2 years.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Public, Environmental & Occupational Health
Xiyue Huang, Shanshan Ying, Lan Luo, Lixin Li, Dongdong Li, Yi Xie
Summary: This study quantitatively assessed intrathecal protein synthesis in patients with neurosyphilis and found an association between different stages of neurosyphilis and intrathecal synthesis of IgM and IgG. The use of specific antibody indices may also serve as a new tool for neurosyphilis diagnosis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Ruiting Zhang, Elisa Ouin, Lina Grosset, Karine Ighilkrim, Jessica Lebenberg, Stephanie Guey, Veronique Francois, Elisabeth Tournier-Lasserve, Eric Jouvent, Hugues Chabriat
Summary: Approximately one in five CADASIL patients can remain neurologically intact after the age of 65, and their clinical and imaging features differ from other age-matched CADASIL patients.
Article
Medicine, General & Internal
Agnieszka Lugowska, Galina Baydakova, Alex Ilyushkina, Ekaterina Zakharova, Hanna Mierzewska, Krystyna Szymanska, Jolanta Wierzba, Jolanta Kubalska, Alla Graban, Tomasz Kmiec, Barbara Perkowska-Sumila, Anna Tylki-Szymanska, Malgorzata Bednarska-Makaruk
Summary: Elevated DPP-IV activity was found in patients with various LSDs, with the most significant increases seen in specific types of mucolipidosis, alpha-mannosidosis, and mucopolysaccharidoses. DPP-IV may serve as a valuable diagnostic tool and subject for further study in the understanding of LSDs.
Article
Clinical Neurology
Laura Cornelissen, Carolina Donado, Timothy W. Yu, Charles B. Berde
Summary: This article discusses the application of gene-targeting therapies, such as antisense oligonucleotides and viral vector-based gene therapy, in the treatment of neurological disorders. It introduces the use of quantitative sensory testing (QST) for detecting sensory dysfunction and presents individualized testing protocols. Through three case studies, the article highlights the limitations and challenges of QST in non-verbal subjects, and calls for collaborative efforts and data sharing in the field of pediatric neurology.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vanessa Cristine de Souza Carneiro, Luciane Almeida Amado Leon, Vanessa Salete de Paula
Summary: This review article discusses the role of miRNAs in neurological disorders associated with herpesvirus. By listing and discussing human miRNAs and herpesvirus-encoded miRNAs, it provides valuable insights for the search of new diagnostic and prognostic alternatives, as well as understanding the role of these miRNAs in neurological diseases triggered by herpesviruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Yizhen Jiang, Xiangwen Tang, Peng Deng, Chao Jiang, Yuqing He, Dingjun Hao, Hao Yang
Summary: Neurological diseases have a significant impact on public health and patient's quality of life. Understanding the unique pathological characteristics and underlying molecular mechanisms of each disease is crucial for effective treatment. Fisetin, a flavonoid derived from natural medicinal plants, shows promising neuroprotective effects and reverses cognitive abnormalities through its multifaceted biological activity and therapeutic mechanisms.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ursula Munoz, Cristina Sebal, Esther Escudero, Maria Isabel Garcia Sanchez, Elena Urcelay, Asier Jayo, Rafael Arroyo, Maria A. Garcia-Martinez, Roberto Alvarez-Lafuente, Maria C. Sadaba
Summary: In this study, a new method for detecting IgA concentration was developed, and it was found that the incidence of IAS in MS patients was higher than previously estimated, and was not related to serum IgA concentration. Patients with clinically isolated syndrome had a particularly high incidence of IAS.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Irma Khachidze, Manana Gugushvili, Maia Advadze
Summary: The study found that all three types of PERH were present in the first, second, and third minutes of HPT across all age and sex groups, showing disorganized basic EEG rhythm. The first minute showed comparable results for both sexes, but some differences were observed between females and males in the second and third minutes. The second and third types of PERH were only found in women, with the second type appearing in 13-18-year-old girls during the second minute of HPT.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Viviana Greco, Cristina Neri, Damiana Pieragostino, Alida Spalloni, Silvia Persichilli, Matteo Gastaldi, Nicola B. Mercuri, Patrizia Longone, Andrea Urbani
Summary: This study investigates the levels of H2S in cerebrospinal fluid and its potential correlations with neuroinflammatory and neurodegenerative mechanisms. A validated analytical method was used to measure H2S forms, showing sensitivity, reproducibility, and robustness. The study also explores the low molecular weight proteome associated with sulphydration through proteomics analysis, paving the way for potential therapeutic applications of H2S.
Article
Immunology
Jonathan Lopez, Marine Mommert, William Mouton, Andres Pizzorno, Karen Brengel-Pesce, Mehdi Mezidi, Marine Villard, Bruno Lina, Jean-Christophe Richard, Jean-Baptiste Fassier, Valerie Cheynet, Blandine Padey, Victoria Duliere, Thomas Julien, Stephane Paul, Paul Bastard, Alexandre Belot, Antonin Bal, Jean-Laurent Casanova, Manuel Rosa-Calatrava, Florence Morfin, Thierry Walzer, Sophie Trouillet-Assant
Summary: The nasal IFN-I/III signature in mildly symptomatic COVID-19 patients correlates with serum IFN-a(2) levels, while critically ill patients with autoantibodies against IFN-I showed low nasal IFN-I/III scores despite high viral loads. Functional assays confirmed the role of autoantibodies in compromising the antiviral effects of IFN-I at the early stages of SARS-CoV-2 infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Neurosciences
Zhuoxin Li, Jie Zhou, Hao Liang, Li Ye, Liuyan Lan, Fang Lu, Qing Wang, Ting Lei, Xiping Yang, Ping Cui, Jiegang Huang
Summary: This study systematically reviewed the relationship between the alpha diversity of the gut microbiota and neurological diseases. The findings suggest that alpha diversity of the gut microbiota could be a promising predictor for certain neurological diseases such as AD, schizophrenia, and MS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Jodi L. Karnell, Yanping Wu, Nanette Mittereder, Michael A. Smith, Michele Gunsior, Li Yan, Kerry A. Casey, Jill Henault, Jeffrey M. Riggs, Simone M. Nicholson, Miguel A. Sanjuan, Katherine A. Vousden, Victoria P. Werth, Jorn Drappa, Gabor G. Illei, William A. Rees, John N. Ratchford
Summary: Plasmacytoid dendritic cells (pDCs) are specialized in producing IFN and regulating immune responses, with persistent activation in autoimmune diseases. VIB7734, a monoclonal antibody, effectively depletes pDCs, reduces IFN activity, and improves clinical disease activity in animal models and patients. Biomarker analysis suggests that VIB7734 may be more effective in individuals with high baseline IFN activity, supporting further development in IFN-associated diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2021)