Article
Medicine, Research & Experimental
Tae-Kyeong Lee, Dae Won Kim, Hyejin Sim, Jae-Chul Lee, Hyung Il Kim, Myoung Cheol Shin, Jun Hwi Cho, Joon Ha Park, Choong-Hyun Lee, Moo-Ho Won, Ji Hyeon Ahn
Summary: According to this study, different subfields of the hippocampus (CA1 to CA3) have different vulnerabilities to ischemia. Hyperthermia exacerbates neuronal death and decreases the expression of HIF-1 alpha, while normothermia does not have the same effects.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Amit Benbenishty, Jacob Schneiderman
Summary: Inhibition of leptin activity in hemispheric IR injury preserved the viability of ipsilateral hippocampal CA1 neurons, likely by preventing apoptosis and local inflammation.
Article
Biochemistry & Molecular Biology
Choong-Hyun Lee, Ji Hyeon Ahn, Tae-Kyeong Lee, Hyejin Sim, Jae-Chul Lee, Joon Ha Park, Myoung Cheol Shin, Jun Hwi Cho, Dae Won Kim, Moo-Ho Won, Soo Young Choi
Summary: Transient ischemia in the brain leads to breakdown of the blood-brain barrier and dysfunction, exacerbating neuronal damage. The duration of ischemia affects the timing and degree of neuronal damage, albumin and IgG leakage, and inflammatory cytokine expression in brain tissue. More severe blood-brain barrier leakage is associated with increased microglial activation and pro-inflammatory cytokine expression in the ischemic hippocampal CA1 region.
NEUROCHEMICAL RESEARCH
(2021)
Article
Computer Science, Interdisciplinary Applications
Wanquan Mei, Yuanyou Xia, Peng-Zhi Pan, Mei Li, Sirong Tan, Yuanhang Zhang
Summary: This study focuses on the theoretical and numerical responses of deep twin circular tunnels subjected to transient disturbance. The analytical and numerical results provide guidance for the support and design of deep-buried tunnels.
COMPUTERS AND GEOTECHNICS
(2022)
Article
Immunology
Yanyao Liu, Zilun Lei, Hao Chai, Song Xiang, Yihua Wang, Ping Yan, Zhenrui Cao, Xingyu Pu, Zhongjun Wu
Summary: This study found that recombinant human thrombomodulin (rTM) can inhibit the formation of neutrophil extracellular traps (NETs), alleviate hepatic ischemia-reperfusion injury (IRI) and improve liver function. rTM blocks multiple signaling pathways to inhibit NETosis. The results suggest that NETs are a potential therapeutic target for hepatic IRI and rTM can be used to prevent liver injury caused by IRI.
Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Myoung Cheol Shin, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Hyejin Sim, Jae-Chul Lee, Jun Hwi Cho, Joon Ha Park, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Lee
Summary: This study investigated the time-dependent changes in CD200 expression in the hippocampus after transient forebrain ischemia in gerbils. The results showed that transient ischemia led to specific and selective neuronal death in the CA1 field, with CD200 expression changing over time. Interestingly, treatment with risperidone did not alter CD200 expression, indicating protection of CA1 pyramidal neurons from ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, the researchers synthesized the Tat-CHIP fusion protein and successfully delivered it into brain cells. The results showed that Tat-CHIP has antioxidant and neuroprotective effects, making it a potential therapeutic agent against ischemic damage.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Bora Kim, Ji Hyeon Ahn, Dae Won Kim, Tae-Kyeong Lee, Yoon Sung Kim, Myoung Cheol Shin, Jun Hwi Cho, Young-Myeong Kim, Joon Ha Park, Il Jun Kang, Jae-Chul Lee, Moo-Ho Won
Summary: The study found that hyperthermic preconditioning accelerates neuronal death caused by transient forebrain ischemia, which is closely related to changes in NMDAR1 expression levels.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Nutrition & Dietetics
Woosuk Kim, Hyo Young Jung, Dae Young Yoo, Hyun Jung Kwon, Kyu Ri Hahn, Dae Won Kim, Yeo Sung Yoon, Soo Young Choi, In Koo Hwang
Summary: The study demonstrates that GPE-R has neuroprotective effects against ischemic damage and inflammation in the hippocampus, reducing locomotor hyperactivity and increasing neuronal survival. It also shows a decrease in pro-inflammatory cytokines and activated microglia after ischemia/reperfusion, indicating GPE-R as a potential agent for protecting neurons from ischemic damage.
Article
Cell Biology
Fuxing Wang, Zihao Xia, Peng Sheng, Yu Ren, Jiajia Liu, Lidong Ding, Bing Chun Yan
Summary: This study found that neuroblast proliferation and differentiation, as well as the maturation into functional neurons, were higher in young gerbils following cerebral ischemia/reperfusion compared to old gerbils. Additionally, the neurological function, cognitive function, and memory function improved faster in the young gerbils. The phosphorylation of MEK1/2, ERK1/2, p90RSK, and MSK1/2 protein levels, as well as the levels of autophagy-related proteins, were also higher in the hippocampus of young gerbils.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Bora Kim, Hyejin Sim, Jong Dai Kim, Ji Hyeon Ahn, Joon Ha Park, Choong-Hyun Lee, Moo-Ho Won, Soo Young Choi
Summary: The study demonstrates that ischemic brain damage or death induced under hyperthermic conditions is more severe and widespread than under normothermic conditions, with differing effects of HO-1 expression in neurons and astrocytes based on brain subregions and temperature conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Civil
Stefano Brusco, Giovanni Solari
Summary: The literature is rich in studies on the instability of structural systems under steady flows, but lacks clear references on aeroelasticity induced by thunderstorm outflows. This paper proposes a mathematical model to consider the aeroelastic effects of thunderstorm outflows on slender structures. The methodology for synoptic winds may be derived as a particular case from this model.
ENGINEERING STRUCTURES
(2021)
Article
Oncology
Choong Hyun Lee, Ji Hyeon Ahn, Bai Hui Chen, Dae Won Kim, Hyejin Sim, Tae-Kyeong Lee, Joon Ha Park, Moo-Ho Won, Soo Young Choi
Summary: This study compared the time-dependent changes in TNF-alpha and TNF-R1 protein expression levels in the hippocampal subfield CA1 between adult and young gerbils following cerebral ischemia, finding different expression patterns between the two age groups. The higher levels of TNF-alpha in young gerbils compared with adult gerbils may be related to age-dependent differences in neuronal death induced by ischemia.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Mallikarjunarao Ganesana, B. Jill Venton
Summary: Spontaneous, transient adenosine signaling increases in frequency in the caudate-putamen during early stages of mild ischemia-reperfusion injury; while in the milder model fewer spontaneous, transient adenosine events were observed, but no change in concentration. In contrast, both the frequency and concentration of spontaneous, transient adenosine decreased in moderate and severe ischemia models. Blood flow measurements confirm decreased blood flow in the ischemia models, with corresponding pathological changes observed by transmission electron microscopy.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biology
Rebecca A. Mount, Sudiksha Sridhar, Kyle R. Hansen, Ali Mohammed, Moona Abdulkerim, Robb Kessel, Bobak Nazer, Howard J. Gritton, Xue Han
Summary: The study found that different populations of hippocampal CA1 neurons play different roles in trace conditioning and extinction learning, with unique connectivity patterns. Additionally, differences in CA1 network connectivity were observed between conditioning and extinction, despite overall connectivity density remaining constant.
