Journal
ACTA NEUROLOGICA SCANDINAVICA
Volume 118, Issue 4, Pages 260-267Publisher
WILEY
DOI: 10.1111/j.1600-0404.2008.01010.x
Keywords
atrophy; basal ganglia calcifications; computed tomography; lacunes; infarcts; population study; visual rating; white matter lesions
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Funding
- Swedish Research Council [11267, 2005-8460]
- Swedish Council for Working Life and Social Research [2001-2835, 2001-2646, 2003-0234, 2004-0150, 2006-0020, 2004-0145, 2006-0596]
- Bank of Sweden Tercentenary Foundation
- Alzheimer's Association Zenith Award [ZEN-01-3151]
- Alzheimer's Association [IIRG-00-2159]
- Swedish Brain Power
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Objective - To measure the prevalence of computed tomography (CT)-detected cerebral lesions in a population-based sample of elderly persons living in Goteborg, Sweden. Methods - Cerebral CT-scans were performed in the case of 466 women (mean age 74.3 +/- 5.1 years) and 191 70-year-old men. A single rater assessed white matter lesions (WML) using four different scales, lacunar lesions, large infarcts, cortical atrophy, and basal ganglia calcifications. Results - White matter lesions frequency assessed by different scales ranged between 54.5% and 68.5%. Lacunar lesions were detected in 46.7% (30.1% had lacunes > 5 mm) and cerebral infarcts in 3.0% of participants. Overall, 72.8% of participants evidenced cerebral vascular abnormalities. Severe cortical atrophy was more common in temporal (6.4%) and frontal (6.7%) lobes, than in parietal (1.7%) and occipital (1.1%) lobes. Basal ganglia calcifications were found in 38.7% of participants. WML, lacunar lesions, large infarcts, and degree of cortical atrophy correlated positively with age. More lacunes, basal ganglia calcifications, and occipital lobe atrophy were associated with male gender. Conclusions - Vascular and other brain lesions are very common on CT-scan in an elderly population, but large vascular lesions are rare. This study provides the first reference for the prevalence of CT-detected abnormalities in an elderly Swedish population.
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