Article
Immunology
Ke Shang, Chang Cheng, Chuan Qin, Jun Xiao, Gang Deng, Bi-Tao Bu, Sha-Bei Xu, Dai-Shi Tian
Summary: This case report is the first to describe a demyelination illness associated with anti-flotillin autoantibodies, showing characteristics of both neuromyelitis optica spectrum disease and multiple sclerosis. Although it currently seems to be a subtype of MS, there is still a possibility that it may be distinct from both MS and NMOSD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Laura Clarke, Simon Arnett, Kate Lilley, Jacky Liao, Sandeep Bhuta, Simon A. Broadley
Summary: NMOSD is an inflammatory disease associated with AQP4 antibodies, with distinct features compared to other neurological disorders. Early recognition is crucial due to different treatment responses. MR imaging plays a key role in diagnosis and specific lesion identification, guiding immediate treatment decisions.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David A. Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Cella Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Christopher Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron P. Shaw, Judith M. Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. K. Kermode, Mark P. Marriott, John D. E. Parratt, Mark Slee, Bruce Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
Summary: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS with overlapping clinical and MRI features, but distinguishing them can be achieved with the use of MRI features and machine learning models.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Shaoyue He, Tingting Peng, Weiwei He, Chen Gou, Changyue Hou, Juan Tan, Xiaoming Wang
Summary: This study observed the brain fMRI characteristics during olfactory stimulation in patients with NMOSD and MS. The results showed altered olfactory-related brain networks in both patients, with differences between the two conditions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Qiling Ji, Huiqing Dong, Hangil Lee, Zheng Liu, Yanna Tong, Kenneth Elkin, Yazeed Haddad, Xiaokun Geng, Yuchuan Ding
Summary: This study aimed to differentiate patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) at their first attack by describing and distinguishing their clinical, radiographic, and immunologic characteristics. The results showed significant differences in demographic characteristics, clinical features, and imaging findings between MS and NMOSD patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Petra Nytrova, Ondrej Dolezal
Summary: This review summarizes representative articles on the sex/gender bias in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Sex has significant effects on the incidence, activity, and progression of these disorders, which should be taken into consideration in clinical research and treatment choice. Although some relationships between clinical variables and gender remain unclear, further understanding of sex/gender-related differences can help provide appropriate patient-centered care and research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Maciej Jurynczyk, Elzbieta Klimiec-Moskal, Yazhuo Kong, Samuel Hurley, Silvia Messina, Tianrong Yeo, Mark Jenkinson, Maria Isabel Leite, Jacqueline Palace
Summary: This study identified four distinct subgroups within the antibody-negative NMOSD/MS overlap syndrome, each with different pathological features and MRI findings. Tailored treatment based on these subgroup classifications may optimize outcomes for challenging patients in the NMOSD/MS cohort.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Christina Andica, Akifumi Hagiwara, Kazumasa Yokoyama, Shimpei Kato, Wataru Uchida, Yuma Nishimura, Shohei Fujita, Koji Kamagata, Masaaki Hori, Yuji Tomizawa, Nobutaka Hattori, Shigeki Aoki
Summary: This study combined NODDI and SyMRI to evaluate GM microstructural alterations in RRMS and NMOSD patients, revealing reduced NDI and MVF and increased ODI and ISOVF in RRMS patients, mainly in limbic and paralimbic regions, while NMOSD patients showed reduced NDI in different cortical areas. RRMS and NMOSD exhibited distinct GM pathologies, with cautious interpretation of the results due to study limitations.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Review
Neurosciences
Amir Valizadeh, Mana Moassefi, Elham Barati, Mohammad Ali Sahraian, Faezeh Aghajani, Mohammad-Reza Fattahi
Summary: A meta-analysis of 27 studies involving 1919 participants revealed a correlation coefficient of 0.32 (95% CI 0.26-0.37) between T1 hypointense lesions' mean volume and EDSS score. The correlation was interpreted as low to slightly moderate, with high certainty of evidence.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Woojun Kim, Hyeong-Geol Shin, Hyebin Lee, Dohoon Park, Junghwa Kang, Yoonho Nam, Jongho Lee, Jinhee Jang
Summary: This study evaluated the characteristics of brain lesions in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using chi-separation imaging. The findings showed that MS lesions exhibited a higher proportion of hypodiamagnetic lesions compared to NMOSD lesions, suggesting that this feature can be used to differentiate between the two diseases.
Article
Neurosciences
George Tackley, Yazhuo Kong, Rachel Minne, Silvia Messina, Anderson Winkler, Ana Cavey, Rosie Everett, Gabriele C. DeLuca, Andrew Weir, Matthew Craner, Irene Tracey, Jacqueline Palace, Charlotte J. Stagg, Uzay Emir
Summary: This study characterized the metabolite profiles of brain lesions in MS and AQP4Ab-NMOSD patients using an optimized MRS methodology, revealing some under-explored subtleties in MRS profiles, such as the absence of myo-Inositol concentration differences in AQP4Ab-NMOSD brain lesions versus NAWM and the potential influence of NAAG differences between lesions and normal appearing white matter in MS.
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica and its spectrum is a relapsing demyelinating disorder of the central nervous system, encompassing six syndromes and associated with aquaporin-4 autoantibodies. Effective treatment is able to prevent relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica, previously known as Devic's disease, is a relapsing demyelinating disorder of the central nervous system that encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment is crucial in preventing relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lan Huang, Ziqi Zhao, Liying An, Yingchun Gong, Yao Wang, Qixing Yang, Zhuo Wang, Geli Hu, Yan Wang, Chunjie Guo
Summary: This study presents an automatic segmentation model of contrast-enhancing lesions (CELs) based on FCA-DenseNet and transfer learning strategy, aiming to address the challenge of CEL quantification in small-scale datasets. The FCA-DenseNet outperforms other models in terms of evaluation metrics, demonstrating the effectiveness of the proposed method.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neuroimaging
Jianpan Huang, Jiadi Xu, Joseph H. C. Lai, Zilin Chen, Chi Yan Lee, Henry K. F. Mak, Koon Ho Chan, Kannie W. Y. Chan
Summary: Multiple sclerosis (MS) is an autoimmune disease involving inflammation and damage to the central nervous system. The use of rNOEw imaging technique shows promise in assisting clinical diagnosis of MS and differentiating it from neuromyelitis optica spectrum disorders (NMOSD).
NEUROIMAGE-CLINICAL
(2021)